손상받은고양이 줄무늬체에서 축삭반응에 관한 미세구조적 연구

양남길,조영열,안의태,고정식,박경호,김진국 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

발꿈치힘줄이 절단된 흰쥐의 가자미근과 장단지근내의 모세혈관과 신경섬유의 형태학적 연구

고정식,최기수,양남길,안의태,박경호,김진국 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.1

X-선 조사를 받은 흰쥐망막 빛감각세포의 미세구조

고정식,박동분,양남길,안의태,박경호,김진국 대한해부학회 1993 Anatomy & Cell Biology Vol.26 No.3

고밀도 유도결합 플라즈마 시뮬레이터의 GUI 및 Post Processor 개발

남경진, 김용일, 권득철, 윤남식 충북대학교 컴퓨터정보통신연구소 2007 컴퓨터정보통신연구 Vol.15 No.2

-본문참고-

Greedy 알고리즘을 이용한 라이브러리 맵핑에 관한 연구

조남경,김재진,음호식 공주영상정보대학 1999 논문집 Vol.6 No.-

본 논문은 원천 컴포넌트의 기능보다 목표 컴포넌트의 기능이 적을 경우 목표 컴포넌트로 동일한 기능을 수행하는 Greedy 알고리즘을 제안하였다. Greedy 알고리즘은 각 컴포넌트의 함수를 비교하여 목표 컴포넌트에 부족한 기능을 수행할 수 있는 잉여 로직을 추가하여 맵핑하는 알고리즘이다. 예제로 선정한 원천 ALU는 3개의 산술기능을 갖고있고 목표 ALU는 2개의 산술기능을 갖고 있는 컴포넌트이다. 본 논문의 Greedy 알고리즘을 이용하여 동일한 기능을 수행하기 위하여 맵핑된 결과 2×1 MUX 1개와 인버터 1개가 추가되어 동일한 기능을 수행하였다. 따라서 실제의 시스템을 구현할 때 CAD 물상에서 라이브러리가 제공되지 않을 경우, 본 논문에서 제안한 HLLM 기술을 이용하여 기본적으로 제공되는 라이브러리를 이용하여 동일한 기능을 수행할 수 있었다.

Vinyl monomer에 의한 SIS block copolymer의 改質과 그 特性

왕은진,윤정식,유종선,백남철 慶熙大學校 材料科學技術硏究所 1991 材料科學技術硏究論集 Vol.4 No.-

The graft polymerization of 2-Hydroxyethylmethacrylate (HEMA) and Vinyltriethoxysilane (VTES) onto Styrene-isoprene-styrene block copolymer (SIS) was carried out in toluene, with radical initiators such as benzoyl peroxide(BPO) and α, α`-Azobisisobutyronitrile(AIBN) under nitrogen atmosphere. The degree of grafting was increased with the increases of the reaction temperature and reaction time. The efficiency of BPO was superior to that of AIBN. The mechanical properties and molecular weight of graft products were measured and the applicability as a adhesive of plasticized PVC leather was examined. The hardness and the molecular weight of graft products was increased with the increases of the degree of grafting, but elongation at break was decreased with the increases of one. And the tensile strength was maximum at the degree of grafting of about 6.5%. It was found that a toluene solution of graft products was confirmed to be an effective hot melt adhesive for the bond of plasticized PVC leather.

4세 유아에 발생한 몰입성 하마종(plunging ranula); 증례보고

최진호,양동환,김일규,오남식 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.4

Whereas oral ranula is relatively common and presents as a cyst in the mouth, the plunging ranula is rare and manifests itself as a mass in the neck with or without an associated oral lesion. When there is a soft anterior neck swelling without oral swelling, diagnosis is still difficult. In such a case, clinical suspicion may be low and the pathologist may be misled by the histologic appearance. Recognition of the diagnosis of plunging ranula is essential for the correct treatment of these lesions We report a case of a 4-year-old girl and review the literatures to discuss the differential diagnosis and treatment modalities.

누두흉 환자에서 Nuss 금속막대 제거 전 · 후 폐 역학 변화

강규식,백남순,김천숙,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Nuss operation is one of the surgical procedure for pectus excavatum and it's method is the insertion of convex steel bar under the sternum through small bilateral thoracic incision. As the patients is growing, the thorax can be compressed gradually by steel bar. So Nuss bar needs to be removed two years after Nuss operation. This study was undertaken to assess the effect on the repiratory mechanics before and after the removal of the Nuss bar. Twenty patients with previous Nuss operation were allocated for the removal of Nuss bar. Lung mechanics (dynamic lung compliance, static lung compliance, and airway resistance), hemodynamic change (heart rate, systolic pressure, and diastolic pressure), and pulmonary gas exchange (arterial oxygen tension, arterial carbon dioxide tension, pulse oximeter saturation, and end tidal carbon dioxide tension) were measured before and after removal of Nuss bar. Respiratory mechanics (dynamic and static lung compliance, inspiratory airway resistance), pulmonary gas exchange and hemodynamic parameter were unchanged before and after the removal of Nuss bar. We concluded that lung mechanics were not changed before and after the removal of Nuss bar in the patients with pectus excavatum and the 95% patients were satisfied with operation.

배양된 간세포 담세관 및 세포질소기관의 미세구조 연구 : Phalloidin과 Cytochalasin D의 영향 Effects of Phalloidin and Cytochalasin D

김진국,양남길,안의태,고정식,박경호,김주원 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

간세포 담세관의 주위세포질에는 미세사가 풍부하게 분포하는데, 이 실험에서는 배양 간세포의 미세사형성을 촉진 또는 억제시킨 후에 담세관 및 세포질소기관의 미세구조를 관찰하여 미세사의 형태학적 및 기능적 의의를 연구하였다. Sprague Dawley계 숫흰쥐의 간조직에 IV형 collagenaseㄹ를 처리하여 간세포를 분리한 후 배양하며 phalloidin(미세사 중합 촉진제)이나 cytochalasin D(미세사 중합 억제제)를 배지에 투여하고 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. 분리된 간세포 세포질에는 골지복합체와 소포 및 용해소체들이 세포의 일부분에 분포되어 생체의 간세포와 같이 세포질소기관 분포의 극성을 나타냈다. 2. Phalloidin와 cytochalasin D 투여군이 담세관은 확장되고 미세융모의 소실이 뚜렷하였다. Phalloidin투여군에서는 미세사가 증식되고 외형질층이 두터워져 담세관은 경직된 모습이었고, cytochalasin D투여군에서는 미세사가 감소되고 담세관의 확장은 더욱 심했다. 3. Phalloidin이나 cytochalasin D 투여군 모두에서 간세포 표면에는 세포질이 돌출되었다. Phalloidin투여군에서는 돌출부의 연결부분이 잘록하였고 외형질에 미세사가 증식되어 돌출부와 세포질을 분리시키고 있었다. 반면에 cytochalasin D투여군에서는 외형질층에서 미세사가 뚜렷한 감소되었고 각종 세포질소기관들이 포함된 채로 세포질 일부를 밀고나와 반구형의 돌출부를 이루었고 연결부는 넓었다. 4. 세포질에는 많은 소포와 공포들이 융합되어 세포의 주변부분이나 담세관주위에 세포내공간이 형성되었는데, 이 공간은 세포바깥이나 담세관과 교통되었다. 이상의 결과를 보면, 미세사가 증식 혹은 감소되면 배양간세포의 모습이 변화되며, 담즙의 이동에도 장애가 생겨 담즙정체를 일으킨다. 따라서 미세사는 간세포의 형태유지 및 담즙분비에 중요하게 관여하는 것으로 생각된다. The cytoplasmic microfilaments of hepatocytes are abundant beneath the plasma membrane, especially in the pericanalicular ectoplasm. In this study, the ultrastructural changes of bile canaliculus and cytoplasmic organelles induced by alteration of the microfilaments on the cultured rat hepatocytes were examined. Sprague-Dawley rats(male, about 200gm) were used. The isolated hepatocytes obtained by perfusion of 0.05% collagenase type IV through the portal vein, were cultred in the L-15 medium containing phalloidin(stabilizer of microfilaments) or cytochalasin D(destabilizer of microfilaments) for 10 min, 30 min, 1 hour, 2 hours, 4 hours, 10 hours and 20 hours, respecitvely. The hepatocytes on the cultured dish were fixed in 2.5% glutaradehyde -1.5% paraformaldehyde and 1% osmium tetroside. After alcohol dehydration, the cells were embedded in the araldite mixture. Ultrathin sections were contrasted with uranyl acetate and lead citrate, and observed with JEM100 CX-II electron microscope. The results were as follow: 1. Isolated hepatocytes maintained the typical architectionic relationships of secretory organelles, i.e., Golgi apparatus, vesicles, lysosomes, etc., in the vicinity of bile canalicular region. 2. In the phalloidin or cytochalasin D treated groups, bile canaliculi were dilated and devoid of microvilli. In phalloidin treated group, the pericanalicular ectoplasm containing the microfilaments microfilaments was thicker than that of cytochalasin D treated group. Whereas, the dilation of bile canaliculus was more marked in cytochalasin D group. 3. Both drugs, phalloidin or cytochalasin D, produced the alteration of cell shaper to form cytoplasmic protrusions at the cell surface. In the phalloidin treated group, protusions were pedunculated, and the microfilaments were accumulatd at the narrow neck region. In cytochalasin D treated group, in contrast, no microfilament barrier was seen at the broad base of protrusion which exhibit direct continuity with the internal cytoplasm. 4. Numerous vesicles and vacuoles were formed near the cell surface and perianalicular cytoplasm in the treated groups, and later in culture they fused each other to form large intracellular space. Eventurally. this space was connected to the extracellular space or bile canaliculus. This experiment demonstrated that excessive accumulation or depletion of microfilaments induced by phallyoidein or cytochalasin D altered the cell shape and disturbed the vesicular transport of bile components into bile canaliculi. The results suggest that dysfunction of microfilaments may play an imprtant role in the impairement of canalicular contraction and the integrity of microfilaments is necessary for the billiary secretin as well as for the maintainance of the cell shape of hepatocytes.

4,4'-비스-(2-보로노-4-히드록시-벤젠아조)-비페닐의 합성 및 산 염기 지시약으로서의 성질

임용진,윤남식,이석률 慶北大學校 1986 論文集 Vol.41 No.-

A dye, 4,4'-bis-(2-borono-4-hydroxy-benzeneazo)-biphenyl, was synthesized by coupling benzidine tetrazonium salt with m-hydroxybenzeneboronic acid. The dye was soluble in alcohol and it's maximum absorption wavelength (λ_max) and molar extinction coefficient(ε) in ethyl alcohol were 466㎚ and 3.81× 10 exp (4) respectively. The color of the dye was pale yellow(λ_max 400㎚) in acidic aqueous solution and deep blue (λ_max 581㎚) in alkaline aqueous solution, indicating the possibility of using as a neutralization titration indicator. The transition range of the dye as titration indicator was shown to be pH 7.3-8.5 and the equilibrium constant (K_HIn) was 1.90× 10 exp (-8). When the dye was compared with phenolphthalein in the neutralization titration experiment, similar results were obtained.