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( Jin Nyoung Kim ),( Jae Young Jang ),( Soung Won Jeong ),( Jin Woo Choo ),( Soon Ha Kwon ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: Measurement and assessment of portal hypertension are very important in the caring of patients with liver cirrhosis and in predicting relevant prognosis. This study compared the prognostic values of hepatic venous pressure gradient (HVPG), model for end-stage liver disease (MELD)- Na, and Child-Pugh score for the prediction of mortality in patients with liver cirrhosis. Methods: We investigated 136 patients with liver cirrhosis who underwent HVPG between July 2009 and March 2012. Clinical variables including laboratory data, presence of ascites, HVPG, MELD-Na, and Child-Pugh score were collected and analyzed. Cox regression model was developed to identify predictors of mortality. Accuracy of prediction was analyzed using the area under the receiver’s operating characteristics curve (AUROC). Results: HVPG, MELD-Na, Child-Pugh score, hemoglobin, HDL, albumin, and PIVKA2 significantly predicted overall mortality (univariate analysis, p<0.05). MELD-Na was an independent prognostic factor for prediction of overall mortality (multivariate HR; 23.569; p=0.043). Additionally, ascites was an independent prognostic factor for 6 month mortality (multivariate HR; 5.160; p<0.001), MELD-Na and ascites were independent prognostic factors for 12 month mortality (multivariate HR; 1.845, 1.974; p=0.030, p=0.016). AUROC was 0.698 for HVPG, 0.705 for MELD-Na, 0.591 for Child-Pugh score, respectively (p=0.015, p=0.012, p=0.266). Conclusion: MELD-Na is superior than HVPG and CTP score for the prediction of mortality in patients with liver cirrhosis.
( Jin Nyoung Kim ),( Jae Young Jang ),( Soung Won Jeong ),( Jin Woo Choo ),( Soon Ha Kwon ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: Detection and characterization of focal lesions in the liver is critical for screening patients with liver cirrhosis. The aim of this study was to investigate the sensitivity of magnetic resonance imaging (MRI) and spiral computed tomography (CT) for the diagnosis of hepatocellular carcinoma (HCC) and relation between radiologic findings and histopathology in HCC. Methods: One hundred four consecutive patients with HCC diagnosed by liver biopsy or hepatectomy were included. Radiologic findings such as CT and MRI were compared with histopathology. Typical radiologic finding of HCC was defined as early enhancement and early wash-out. Tumor cell differentiation was evaluated using Edmondson-Steiner criteria in liver cores. Results: Thirty one HCCs (29.8%) were grade 1 and 2, seventy three HCCs (70.9%) were grade 3 and 4. The sensitivity for detection of HCC was 83.7% for CT alone, 92.9% for MRI alone, 87.9% for both CT and MRI together, and 96% for either CT or MRI. Typical radiologic finding of HCC on CT has a tendency of well differentiated HCC (p=0.060), and typical findings of HCC on CT and MRI showed a significantly increased well differentiated HCC (p=0.013). Clinical variables were no significantly different according to the histopathology. Conclusion: Typical early enhancement and early wash-out pattern on CT and MRI showed a significantly increased well differentiated hepatocellular carcinoma on histopathology.
( Jin Woo Choo ),( Soung Won Jeong ),( Jae Young Jang ),( Jin Nyoung Kim ),( Soon Ha Kwon ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: The HCV RNA viral load is the predictive factor for sustained viral response in the treatment of chronic hepatitis C. However, it has been reported that HCV RNA viral load is not predictive of eventual outcome of chronic hepatitis C. The relation between HCV RNA viral load and clinical outcome of hepatocellular carcinoma (HCC) is not elucidated, yet. We investigated the relation of HCV RNA viral load to the clinical outcome in HCC. Methods: Among 453 HCC patients, 34 consecutive patients diagnosed with chronic hepatitis C virus infection were classified into two groups by HCV RNA viral load. Group I (n=19) was defined as low HCV RNA viral load less than 2x106 copies/ml, and Group II (n=15) defined as high HCV RNA viral load over 2x106 copies/ml. Characteristics of HCC, complications of cirrhosis, and overall survival were compared between the two groups. Results: Sixteen patients were male (47.1%) and the median age was 69 years. There was no significant difference in age, gender, Child-Pugh score, MELD score, tumor stage, portal vein invasion, distant metastasis, α-fetoprotein, and histology between the two groups. For complications of cirrhosis includeing variceal hemorrhage, ascites, hepatorenal syndrome and hepatic encephalopathy during follow up, there was no significant difference between both groups. Median overall survival was 48.7 months (95% CI, 30.9-66.6) for group I and 54.0 months (95% CI, 36.1-71.9) for group II. (p=0.859). Conclusion: HCV RNA viral load did not affect the clinical outcome in patients with hepatocellular carcinoma.
( Jin Nyoung Kim ),( Kyoung Min Sohn ),( Moon Young Kim ),( Ki Tae Suk ),( Soung Won Jeong ),( Ho Eun Jung ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Jae Young Jang ),( Young Seok Kim ),( Soon Koo Baik ) 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.4
Background/Aims: Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined. Methods: Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices. Results: The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%. Conclusions: The HVPG was higher in patients with first variceal hemorrhage than in those without it. (Clin Mol Hepatol 2012;18:391-396)
Jin Nyoung Ho,Hong Yon Cho,Eun Jeong Lim,Hye Kyung Kim 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.2
Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, which induce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, we investigated the photoprotective effects of aucubin isolated from Eucommia ulmoides. Pretreatment with aucubin markedly suppressed UVB-induced oxidative stress, which manifests as a decrease in intracellular lipid peroxidation, elevation of catalase activity, and reduced glutathione content. In addition, aucubin significantly reduced expression of matrix metalloproteinase-1 (MMP-1) protein (54%) and mRNA. Taken together, these results suggest that aucubin may offer protection against UVB-induced oxidative stress and may be used as a potential agent in prevention of UVB-induced photoaging.
( Jin Nyoung Kim ),( Jae Young Jang ),( Soung Won Jeong ),( Jin Woo Choo ),( Soon Ha Kwon ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background/Aim: Detection and characterization of focal lesions in the liver is critical for screening patients with liver cirrhosis. The aim of this study was to investigate the sensitivity of magnetic resonance imaging (MRI) and spiral computed tomography (CT) for the diagnosis of hepatocellular carcinoma (HCC) and relation between radiologic findings and histopathology in HCC. Methods: One hundred four consecutive patients with HCC diagnosed by liver biopsy or hepatectomy were included. Radiologic findings such as CT and MRI were compared with histopathology. Typical radiologic finding of HCC was defined as early enhancement and early wash-out. Tumor cell differentiation was evaluated using Edmondson-Steiner criteria in liver cores. Results: Thirty one HCCs (29.8%) were grade 1 and 2, seventy three HCCs (70.9%) were grade 3 and 4. The sensitivity for detection of HCC was 83.7% for CT alone, 92.9% for MRI alone, 87.9% for both CT and MRI together, and 96% for either CT or MRI. Typical radiologic finding of HCC on CT has a tendency of well differentiated HCC (p=0.060), and typical findings of HCC on CT and MRI showed a significantly increased well differentiated HCC (p=0.013). Clinical variables were no significantly different according to the histopathology. Conclusion: Typical early enhancement and early wash-out pattern on CT and MRI showed a significantly increased well differentiated hepatocellular carcinoma on histopathology.