http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jigar N. Shah (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Jigar N. Shah,Kashyap N. Shah,Tejal A. Mehta 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.1
Promethazine hydrochloride (PMZ-HCl) is a classical anti-motion sickness drug which has oral bioavailability (25 %) due to extensive hepatic first pass metabolism. To overcome this drawback, novel, fast dissolving sublingual film (FDSF) of drug was developed. FDSF was formulated using pullulan and propylene glycol (PG) by solvent casting method. Complete taste masking was successfully obtained with HP β-CD, aspartame and grape fruit flavour. Complex of drug was proved using Fourier transfer infrared spectroscopy, differential scanning calorimetry and X-ray diffraction studies. Optimization of concentration of pullulan and PG was done using 32 full factorial design. Batches were evaluated for the parameters like elongation, tensile strength, folding endurance and in vitro disintegration studies. In vitro dissolution indicated 100 % drug release within 7.5 min. Environmental scanning electron microscopy studies also showed uniform drug distribution and integrity of film. In vivo sublingual absorption in human indicated that 70 % of drug absorbed in 10 min. The stability studies indicated that label should state ‘‘Store at cool, dry place’’ at temperature 25 ˚C. So by formulating the taste masked FDSF of PMZ-HCl will give faster onset of action and avoid unnecessary drug intake leading to traveller friendly formulation.
-
Brajesh C. Varshney,N.M. Ponnanna,Pranati A. Sarkar,Pragna Rehman,Jigar H. Shah 대한수의학회 2007 JOURNAL OF VETERINARY SCIENCE Vol.8 No.1
Escherichia coli (E. coli) strains were collected from young diarrheic calves in farms and field. Strains that expressed the K99 (F5) antigen were identified by agglutination tests using reference antibodies to K99 antigen and electron microscopy. The K99 antigen from a selected field strain (SAR-14) was heat-extracted and fractionated on a Sepharose CL-4B column. Further purification was carried out by sodium deoxycholate treatment and/or ion-exchange chromatography. Monoclonal antibodies to purified K99 antigen were produced by the hybridoma technique, and a specific clone, NEK99-5.6.12, was selected for propagation in tissue culture. The antibodies, thus obtained, were affinity-purified, characterized and coated onto Giemsastained Cowan-I strain of Staphylococcus aureus (S. aureus). The antibody-coated S. aureus were used in a coagglutination test to detect K99+ E. coli isolated from feces of diarrheic calves. The specificity of the test was validated against reference monoclonal antibodies used in co-agglutination tests, as well as in ELISA. Specificity of the monoclonal antibodies was also tested against various Gram negative bacteria. The developed antibodies specifically detected purified K99 antigen in immunoblots, as well as K99+ E. coli in ELISA and co-agglutination tests. The co-agglutination test was specific and convenient for large-scale screening of K99+ E. coli isolates.
-
S.M. Yadav,N. P. Singh,Kalpana A. Shah,Jigar H. Gamit 대한토목학회 2014 KSCE Journal of Civil Engineering Vol.18 No.7
Unplanned and rapid growth of urban areas of developing countries poses major threat to service providers. Water supply management becomes critical aspect in the above scenario. The onus of managing its supply and distribution rests on the local government of the concerned area. Ahmedabad being world’s third largest and India’s fastest growing city has been selected for analysis of water supply services. Performance evaluation of water supply services for Ahmedabad city was carried out using nine performance indicators suggested by Ministry of Urban Development (MOUD), Government of India. The nine performance indicators as suggested by MOUD are: coverage of water supply connection, per capita supply of water, extent of metering of water connections, extent of non revenue water, continuity of water supply, quality of water supplied, efficiency in redressal of customer complaints, cost recovery of water supply services and efficiency in collection of water supplied related charges. Required data was collected from Ahmedabad Municipal Corporation. Analysis of the data suggests that among all the indicators of supply of water, cost recovery in water supply services, efficiency in redressal of customer complaints, quality of water supplied and efficiency in collection of water supply related charges showed good performance. However, metering of connection, continuity of water supply and non revenue water needs planned efforts to bring them up to the benchmark.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
