The antitumor effect of a thermosensitive polymeric hydrogel containing paclitaxel in a peritoneal carcinomatosis model.

Yu, Jieun,Lee, Hyuk-Joon,Hur, Keun,Kwak, Mi Kyung,Han, Tae Su,Kim, Woo Ho,Song, Soo-Chang,Yanagihara, Kazuyoshi,Yang, Han-Kwang M. Nijhoff ; Kluwer Academic Publishers 2012 Investigational new drugs Vol.30 No.1

<P>The prognosis of peritoneal carcinomatosis is regarded as poor because safe, effective therapeutic modalities are lacking. Intraperitoneal chemotherapy is one treatment option, involving the delivery of a high concentration of chemotherapeutic drugs into the abdominal cavity, but the severe side effects associated with such treatment are a major obstacle in clinical application. We evaluated the anti-cancer effects of intraperitoneal delivery of a thermosensitive polymeric hydrogel containing chemotherapeutics in an animal model of carcinomatosis. The progress of peritoneal carcinomatosis, introduced by injecting a luciferase-transfected human gastric cancer cell line (HSC44Luc) into the peritoneal cavity of nude mice, was quantitatively evaluated by in vivo bioluminescence imaging. Three days after intraperitoneal (IP) injection of HSC44Luc cells, treatment solutions were injected into the peritoneal cavity. Mice were categorized into four groups depending on treatment method; these were (1) a control PBS group (n?=?5), (2) a hydrogel-only group (n?=?5), (3) a paclitaxel solution (30?mg/kg) group (n?=?3), and (4) a hydrogel-with-paclitaxel (15?mg/kg) group (n?=?5). Quantitative photon counting was performed weekly in each animal. Mice were sacrificed on the 5th or 28th day after treatment, for pathologic evaluation. In vivo bioluminescence imaging showed that photon counts in the hydrogel-with-paclitaxel and paclitaxel solution groups were significantly lower than in the PBS group over the entire experimental period. Although neither group of responding mice showed any peritoneal nodules on the 28th day after treatment, only the paclitaxel solution group exhibited dilated edematous changes in the intestine; these side effects were absent in animals treated with hydrogel-with-paclitaxel group. In conclusion, a thermosensitive hydrogel containing paclitaxel may be a safe and effective treatment option for peritoneal carcinomatosis.</P>

Topology Control in Cooperative Wireless Ad-Hoc Networks

Jieun Yu,Heejun Roh,Wonjun Lee,Sangheon Pack,Ding-Zhu Du IEEE 2012 IEEE journal on selected areas in communications Vol.30 No.9

<P>Topology control is to determine the transmission power of each node so as to maintain network connectivity and consume the minimum transmission power. Cooperative Communication (CC) is a new technology that allows multiple nodes to simultaneously transmit the same data. It can save transmission power and extend transmission coverage. However, prior research work on topology control considers CC only in the aspect of energy saving, not that of coverage extension. We observe that CC can bridge (link) disconnected networks and therefore identify the challenges in the development of a centralized topology control scheme, named shape Cooperative Bridges, which reduces transmission power of nodes as well as increases network connectivity. We propose three algorithms that select energy efficient neighbor nodes, which assist a source node to communicate with a destination node: an optimal method and two greedy heuristics. In addition, we consider a distributed version of the proposed topology control scheme. Our findings are substantiated by an extensive simulation study, through which we show that the shape Cooperative Bridges scheme substantially increases the connectivity with tolerable increase of transmission power compared to other existing topology control schemes, which means that it outperforms in terms of a connectivity-to-power ratio.</P>

Educational exercise program affects to physical fitness and gross motor function differently in the severity of autism spectrum disorder

Jieun Yu,Yong-Seok Jee 한국운동재활학회 2020 JER Vol.16 No.5

Topology Control for Increasing Connectivity in Cooperative Wireless Ad Hoc Networks

YU, Jieun,ROH, Heejun,CAO, Jun,PACK, Sangheon,LEE, Wonjun,DU, Ding-Zhu,HONG, Sangjin (Stephen) The Institute of Electronics, Information and Comm 2010 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.93 No.4

<P>We propose a novel topology control scheme that reduces the transmission power of nodes and increases the network connectivity, based on the fact that Cooperative Communication (CC) technology can bridge disconnected networks. Simulation results demonstrate that our scheme greatly increases the connectivity for a given transmission power, compared to other topology control schemes.</P>

The process of National Health Insurance coverage for Chuna Manual Therapy in Korea: A qualitative study

Yu Jieun,Shin Byung-Cheul,Kim Hyunmin,Hyun Eunhye,Lee Jin-Ho,Kim Me-Riong,Lim Byungmook 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1

Background: Chuna Manual Therapy (CMT) has been widely used in Korea, and coverage in Korean National Health Insurance (NHI) was finally implemented in 2019. The objectives of this study were to analyze the process of NHI coverage for CMT qualitatively, and to summarize important roles, streams, and implications regarding its inclusion in the modern public health insurance system. Methods: Related literature was collected and 8 key personnel involved in the policy-making process were qualitatively interviewed, and Zahariadis’ version of the Multiple Streams Framework (MSF) was applied to analyze the policy agenda setting and the roles of stakeholders. Results: Through the collaborative efforts of various stakeholders, a pilot coverage project for CMT was implemented in 2017, and coverage was expanded nationwide in 2019. MSF showed that it was mainly achieved through three streams: governmental change (political stream), demand from the general public and KM doctors (problem stream), and strengthening/reinforcement of the feasibility and acceptability of the policy (policy steam). Also, the roles of policy entrepreneurs and resulting changes were shown to be significant for the overall process. Conclusion: NHI coverage for CMT was realized through collective policy and research efforts from the government and academic sectors. The roles of stakeholders were shown to be significant in the overall process, and documentation of their involvement is hoped to be of use of other countries that utilize traditional and/or manual medicine. Background: Chuna Manual Therapy (CMT) has been widely used in Korea, and coverage in Korean National Health Insurance (NHI) was finally implemented in 2019. The objectives of this study were to analyze the process of NHI coverage for CMT qualitatively, and to summarize important roles, streams, and implications regarding its inclusion in the modern public health insurance system. Methods: Related literature was collected and 8 key personnel involved in the policy-making process were qualitatively interviewed, and Zahariadis’ version of the Multiple Streams Framework (MSF) was applied to analyze the policy agenda setting and the roles of stakeholders. Results: Through the collaborative efforts of various stakeholders, a pilot coverage project for CMT was implemented in 2017, and coverage was expanded nationwide in 2019. MSF showed that it was mainly achieved through three streams: governmental change (political stream), demand from the general public and KM doctors (problem stream), and strengthening/reinforcement of the feasibility and acceptability of the policy (policy steam). Also, the roles of policy entrepreneurs and resulting changes were shown to be significant for the overall process. Conclusion: NHI coverage for CMT was realized through collective policy and research efforts from the government and academic sectors. The roles of stakeholders were shown to be significant in the overall process, and documentation of their involvement is hoped to be of use of other countries that utilize traditional and/or manual medicine.

Experiments and numerical simulations of the welding speed influence on the microstructure and anisotropic property in Ti-6Al-4V wire-arc additive manufacturing

Jieun Yu(유지은),Guo Xian,Muralimohan Cheepu,Sangmyung Cho(조상명),Namhyun Kang(강남현) 대한용접·접합학회 2022 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2022 No.5

In-situ Observation and Modeling of Intermetallic Compound Growth Induced by Electromigration in Sn-2.5Ag Solder Joints with OSP and ENEPIG Surface Finish

Jieun Yu,Myeonghwan Choi,Dong-Yurl Yu,Won Sik Hong,Cheolho Park,강남현 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.3

The predicted growth behavior of intermetallic compound (IMC) induced by electromigration of a Cu/organic solderabilitypreservative (OSP)/Sn-2.5Ag solder/electroless nickel electroless palladium immersion gold (ENEPIG)/Cu joint was calculatedfor a current density of 14 kA/cm 2 and current application time of 600 h and validated experimentally. Under as-refl owconditions, thin Cu 3 Sn and scallop-shaped Cu 6 Sn 5 layers were produced near the OSP interface, and a (Cu, Ni) 6 Sn 5 layer wasformed near the ENEPIG interface. Cu 6 Sn 5 islands and Ag 3 Sn with a β-Sn matrix were formed in the solder. The mobilitiesof Cu, Ni, and Sn atoms at the OSP and ENEPIG interfaces were calculated, and a relationship was found between IMCthickness and current application time. Under electron fl ow from the OSP to ENEPIG interface, the predicted total thickness(26.6 μm) of the IMCs (Cu 3 Sn, Cu 6 Sn 5 , and (Cu, Ni) 6 Sn 5 ), was in agreement with the experimental value (24.7 μm). With electron fl ow reversed, the predicted IMC thickness (14.2 μm) was similar to the experimental value (13.2 μm). Theapplication of current during electromigration only coarsened Cu 6 Sn 5 , regardless of the direction of electron fl ow. Finally,the Ni plating layer on the ENEPIG surface fi nish prevented the diff usion of Cu and suppressed electromigratory IMC growthby approximately 50%.

방송통신 결합상품 이용자의 만족도 및 전환의향 연구

유지은(Jieun Yu),이성준(Seong-Jun Lee) 한국통신학회 2017 한국통신학회 학술대회논문집 Vol.2017 No.6

한의학 분야 연구윤리 교육에 대한 전국 한의과대학 및 한의학전문대학원 교수들의 인식

유지은(Jieun Yu),천목은(Mog-enu Cheon),임병묵(Byungmook Lim),권영규(Young-kyu Kwon),김병주(Byung Joo Kim) 대한한의학회 2015 대한한의학회지 Vol.36 No.3

체육교사 연수 프로그램을 통한 메타버스 체육수업 활용 가능성 탐색

유지은(Jieun Yu),윤주석(Juseok Yun) 한국스포츠교육학회 2023 한국스포츠교육학회지 Vol.30 No.3

본 연구는 메타버스 체육수업의 활용 가능성을 탐색하는데 목적이 있다. 이를 위해 체육교사 182명을 대상으로 메타버스 개념에 대한 교육과 함께 메타버스 환경을 활용한 운동 프로그램을 체험시켰다. 자료수집은 연수에 참여한 체육교사의 개방형 설문과 메타버스를 활용한 집단토의를 통해 이루어졌으며, 수집한 자료를 귀납적 분석과 내용별 빈도분석을 통해 메타버스 경험을 고찰하였다. 메타버스가 적용된 연수 프로그램의 체험을 바탕으로 ‘시ㆍ공간을 뛰어넘는 체험 중심의 체육수업 실현 가능’, ‘블렌디드 러닝을 향한 의미 있는 발걸음’, ‘학습 상호작용의 어려움’, ‘학습자 중심의 인터페이스 구축 필수’, ‘메타버스 체육수업을 향한 희망과 우려의 목소리 공존’으로 메타버스 체육수업의 활용 가능성을 탐색하였다. 연구 결과를 통해 다음과 같이 제언하고자 한다. 첫째, 미래 교육을 준비해야 하는 체육교사는 새로운 환경과 기술에 적극적으로 관심을 가지고 다양한 프로그램을 체험한 후 그 환경에 적절한 수업설계를 해야 한다. 둘째, 메타버스 환경에서의 수업설계를 준비할 수 있도록 다양한 교사연수와 실습환경 구축이 무엇보다 선행되어야 한다. 셋째, 메타버스 교육환경의 한계점을 명확하게 판단하고, 이러한 기술 향상을 위해서는 체육 교육 현장의 목소리에 귀를 기울여야 한다. The purpose of this study was to explore metaverse environmental physical education lessons and how they can be adapted and utilized in actual physical education classes. To this end, training and hands-on experiences were conducted with 182 in-service physical education teachers who were interested in applying metaverse lessons. Data were collected through open-ended questionnaires and group discussions using the metaverse, and the data were analyzed through inductive analysis and frequency analysis by content, and presented as the content, teaching-learning method, and evaluation of physical education classes using the metaverse. Based on the experience of the yoga program using the metaverse, we found that the content of physical education classes using the metaverse can be immersive and learner-centered education that transcends time and space, the teaching-learning method is suitable for mixed classes using individual exercises or game rules rather than competitive sports, and the educational assessment should provide motivating and qualitative tasks that can be self-assessed even in an invisible virtual world. Based on the results of this study, we would like to make the following suggestions: First, physical education teachers preparing for future education should be actively interested in new environments and technologies and design lessons suitable for them through various experiences. Second, it is necessary to establish various teacher training and practice environments that can prepare teachers for designing lessons in a metaverse environment. Third, it is necessary to clearly determine the limitations of the metaverse education environment and listen to the voices of the physical education field to improve it.