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- 저자 : Jianzhong Pei (검색결과 4 건)
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Glucocorticoid-induced expansion of classical monocytes contributes to bone loss
Liu Pei,Gao Youshui,Luo Pengbo,Yu Hongping,Guo Shang,Liu Fuyun,Gao Junjie,Xu Jianzhong,Wang Shengdian,Zhang Changqing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow. The role of this cell population in high-dose exogenous GC-induced osteoporosis (GIOP) remains to be elucidated. In this study, GIOP was established in rats and mice by daily methylprednisolone injection, and monocyte subsets were analyzed by flow cytometry. We demonstrated that classical monocytes accumulate in bone marrow during GIOP. Similarly, the monocyte proportion among bone marrow nucleated cells was also increased in patients with steroid treatment history. We sorted classical monocytes and analyzed their transcriptional profile in response to GCs by RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that classical monocytes isolated from GC-treated rats exhibited osteoclast differentiation potential. Deletion of classical monocytes by clodronate liposome treatment prevented GIOP via inhibition of osteoclastogenesis and restoration of CD31HiendomucinHi vessels. Regarding the molecular mechanism, classical monocytes express high levels of glucocorticoid receptors. In vitro treatment with GCs increased both the percentage and absolute number of monocytes and promoted their proliferation. In summary, classical monocytes mediated GC-induced bone loss and are a potential target for therapeutic intervention in GIOP treatment.
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Yanqiu Bi,Yong Wen,Jianzhong Pei,Jiupeng Zhang,Rui Li 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.3
As a viscoelastic material, asphalt mixture mainly derives its viscoelastic properties from the asphalt binder. This research aims to comparatively evaluate the strain response regularity of asphalt binder and asphalt mastic through repeated creep and recovery (RCR) test indices. The influences of the asphalt binders, filler volume fraction and filler type on the strain response indices: deformation recovery rate (R) and non-recoverable creep compliance (Jnr) were analyzed according to the RCR test results of the mastics. The viscoplastic (VP) model for characterizing asphalt binder and asphalt mastic behavior was described. The parameters of the model were determined in the prepeak region of the loading, under different stress levels. Simultaneously, the prediction accuracy of the developed VP model was verified, and the applicability of the model was analyzed. The filler volume fraction has the most significant effect on the strain response of the mastic. The R value decreases but the Jnr value increases with the filler volume fractions. The average non-recoverable percent Jnr value decreases with the aging degree increasing. Compared with the unaged (OR) mastics, the Jnr values after rolling thin film oven test (RTFOT) and pressure aging vessel (PAV) decreases by more than 20% and 88%. The improved strain hardening VP model can better simulate the viscoplastic strain response of the asphalt binder and mastic in the RCR test, and the prediction accuracy was greatly improved. The prediction accuracy slightly decreased with creep time increasing. Further research shows that the improved strain hardening VP model is also applicable to the calculation of viscoplastic strains in the RCR test of the asphalt binder and the mastic after RTFOT aging and PAV aging. The improved VP model increases from 5% to 92% off the reference line to within 3%.
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Life-Cycle Reliability Evaluation of Semi-Rigid Materials Based on Modulus Degradation Model
Jiupeng Zhang,Shengchao Cui,Jun Cai,Jianzhong Pei,Yanshun Jia 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.6
The dynamic modulus of semi-rigid material is one of the important material parameters widely used in the design and evaluate ofasphalt pavement, which has a great effect on the reliability, healthy condition and service life of pavement. To show the three-phasedegradation process of dynamic modulus accurately and calculate the time-dependent reliability based on fatigue damage, thedegradation models based on non-linear fatigue damage and improved Wei-bull distribution modulus degradation are established andtestified in this paper, considering the threshold of normalized modulus. Then the reliability models based on the two abovedegradation process models are evaluated. Finally, the reliability analysis procedure is established using Monte Carlo (MC) methodand the corresponding calculation is conducted using Matlab. Cement stabilized macadam is used as an example in this paper. Results show that non-linear fatigue damage and improved Wei-bull distribution modulus degradation models can indicate threephasedegradation process of semi-rigid material modulus better and the reliability based on the proposed two models was moreaccurate to the actual situation.
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Analysis of the Tire-Pavement Contact Stress Characteristics during Vehicle Maneuvering
Haiqi He,Rui Li,Qihui Yang,Jianzhong Pei,Fucheng Guo 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.7
The vehicle maneuvering condition plays an important role in the analysis of the contact stress characteristics of the tire-pavement interaction. A reliable three-dimensional (3D) tire-pavement interaction model was developed to simulate the interface contact stress at static and various rolling conditions (free rolling, acceleration and braking). First, the 205-55-R16 radial tire was modeled accurately comprised of its special pattern and materials in the finite element software ABAQUS. Next, we analyzed and compared these contact stress characteristics,including the distribution of contact stress, the peak contact stress and the variation of stress with time at free rolling, acceleration and braking conditions. Results showed that under the same vehicle load and inflation pressure, the tire-pavement contact stresses at free rolling condition are always much larger than those at static loading condition. At acceleration condition, the peak contact stress occurs at the inner edge of the tire outermost ribs. At deceleration condition, the stress concentration on the tire tread is weakened with the extension of time. The peak contact stress increases with time at acceleration and braking conditions. But the peak contact stress at braking is much larger than that at acceleration condition under the same load and inflation pressure.
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