Topology Optimization of Steel Structure for Waste Incineration Steam Generator Based on DE and PSO

Jianling Chen,Yu-Hang Wang,Xu Zhan 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

The paper presents a topology optimization of steel structure about a waste incinerator steam generator to get economical structural layout. Firstly, the load function is got by analyzing the load distribution of a top girder about a certain type of waste incinerator steam generator. According to the theory of structural mechanics, the axial load function of steel frame is proposed. Secondly, the reasonable section class for members are selected and the functional relationship in the steel amount for steel frame with several variables is established. But it is diffi cult to solve them by ordinary analytic method due to these variables are interrelated. Therefore, intelligent bionics algorithm such as DE-diff erential evolution algorithm and PSO-particle swarm optimization are employed, the two algorithms are compared in the experiment. The simulation results show that the intelligent bionic algorithm can eff ectively deal with the optimization problems of steel structure.

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration

Wang Jianle,Xia Dongdong,Lin Yan,Xu Wenbin,Wu Yaosen,Chen Jiaoxiang,Chu Junjie,Shen Panyang,Weng Sheji,Wang Xiangyang,Shen Lifeng,Fan Shunwu,Shen Shuying 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Low back pain, triggered by intervertebral disc degeneration (IVDD), is one of the most common causes of disability and financial expenditure worldwide. However, except for surgical interventions, effective medical treatment to prevent the progression of IVDD is lacking. This study aimed to investigate the effects of circKIF18A, a novel circRNA, on IVDD progression and to explore its underlying mechanism in IVDD. In this study, we found that oxidative stress was positively correlated with nucleus pulposus cell (NPC) senescence in IVDD and that circKIF18A was downregulated in IVDD and attenuated senescent phenotypes such as cell cycle arrest and extracellular matrix degradation in NPCs. Mechanistically, circKIF18A competitively suppressed ubiquitin-mediated proteasomal degradation of MCM7, and the protective effects of circKIF18A on NPCs were partially mediated by MCM7 under oxidative stress. Intradiscal injection of adenoviral circKIF18A ameliorated IVDD in a rat model. This study revealed that circKIF18A regulates NPC degeneration by stabilizing MCM7 and identified a novel signaling pathway, the circKIF18A-MCM7 axis, for anti-senescence molecular therapy in IVDD.

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

Huang Yizhen,Zhang Zhenlei,Wang Jianle,Shen Shuying,Yao Teng,Xu Yining,Chen Zizheng,Fang Bin,Ma Jianjun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

The abnormal expression of circular RNAs (circRNAs) is associated with numerous human diseases. This study investigated the mechanism by which circRNA acts as competitive endogenous RNA in the regulation of degenerative intervertebral disc disease (IVDD). Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated. The interaction between circSPG21 and miR-1197 and its target gene ( ATP1B3 ) was studied by online database prediction and molecular biological verification. Finally, the circSPG21/miR-1197/ATP1B3 axis was verified in the mouse tail-looping model. The expression of circSPG21 in the nucleus pulposus in IVDD was directly related to an imbalance of anabolic and catabolic factors, which affected cell senescence. circSPG21 was found to play a role in human NPCs by acting as a sponge of miR-1197 and thereby affecting ATP1B3 . The regulation of circSPG21 provides a potentially effective therapeutic strategy for IVDD.

Preparation and Characterization of Emulsified Solid Dispersions Containing Docetaxel

Ying Chen,Qiongzhi Shi,Zhiyu Chen,Jianling Zheng,Hengjun Xu,Jiazhi Li,Hong Liu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11

An emulsified solid dispersion of docetaxel was prepared and characterized in vitro. In contrast to conventional solid dispersions, emulsifying pharmaceutical excipients and hydroxypropyl methylcellulose (HPMC) as a supersaturation promoter were introduced into the PEG6000-based solid dispersion to further improve its solubilizing capability. The solubility, dissolution in vitro and stability of the prepared emulsified solid dispersions were studied taking into consideration of the effects of different emulsifying excipients, preparation methods and the media. Results of the emulsified solid dispersion of docetaxel showed that the solubility and dissolution at 2 h were 34.2- and 12.7-fold higher than the crude powder. The type of emulsifying excipient used had a significant influence on the dissolution of the emulsified solid dispersion. The dissolution of the emulsified solid dispersion prepared by the solvent-melting method or the solvent method was higher than the melting method. There were no apparent differences among the dissolution media utilized. The status of the drug in the emulsified solid dispersion was observed in an amorphous or a molecular dispersion state by differential thermal analysis and powder Xray diffraction. In conclusion, the incorporation of emulsifying pharmaceutical excipients and HPMC with polymers into a solid dispersion could be a new and useful tool to greatly increase the solubility and dissolution of poorly water-soluble drugs.

Optimization of the Field Shaper Parameters in Electromagnetic Pulse Crimping of Cable

Fen-Qiang Li,Jishuai Jiang,Hongsong Cheng,Jianling Xu,Xiaohong Ge,Hui Li,Jun Zhao,Yang Ran 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.10

Crimping of wires to achieve a secure connection is one of the most critical challenges in fabrication of electronic circuit boards, automobiles, aviation, satellite and communication components. The electromagnetic pulse crimping process offers great potential to successfully address these challenges. In this paper, ANSYS/Multi physical software was used to first determine the electromagnetic force distribution on the terminal lug by analyzing the magnetic field in the electromagnetic pulse crimping process. The electromagnetic force was then imported into the ABAQUS/Explicit software as the boundary condition to calculate the deformation behavior of the terminal lug barrel and cable according to the stress–strain curve of the terminal material under high strain rate. The calculated deformation result was subsequently verified by experimental data. Three main parameters of the field shaper were analyzed to determine their influence on the crimping result; slit position, the inner diameter vertical dimension and the position relationship between the terminal lug and field shaper. Then using the empirical formula we calculated and verified the inner diameter vertical dimension of the field shaper. The model proved to be reliable. Deformation of the terminal was determined to be uneven along the circumference in the crimping area. For the type of terminal lug studied, an inner diameter vertical dimension of 10 mm proved to be optimum for increased strength of the crimped terminal connection. Allowing the terminal to protrude 1 mm from the field shaper resulted in a flatter crimped area and significant improvement in the quality of the crimped barrel surface. The empirical formula for calculating the inner diameter vertical dimension of the field shaper is reasonable and reliable, and the calculated measurement resulted in improved connection strength. The results of this research can be used to guide the electromagnetic pulse crimping of other terminal lug and cable types.

Toward efficient broad-spectrum UV absorption of carbon dots: Facile preparation, performance characterization and its application as UV absorbers

Jiemin Qiu,Weihao Ye,Congcong Chen,Zhiqiang Xu,Chaofan Hu,Jianle Zhuang,Hanwu Dong,Bingfu Lei,Guangqi Hu,Yingliang Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-

UV absorbers are sustainable substances that inhibit the ultraviolet (UV) radiative degradation of polymers. In previous reports, the as-prepared carbon dots (CDs) possess only an absorption band at UVA(320–400 nm). To achieve broad-spectrum UV absorption (200–400 nm), increasing the concentrationof the CDs solution becomes common. However, a high concentration solution seriously affects the lighttransmittance due to its heavy yellow color. Furthermore, the promising organic UV absorbers cannotachieve broad-spectrum UV absorption. In this work, we initially synthesized three-component watersolublecarbon dots (OP–CDs), which delivers an excellent UV absorption (98 % UVA and 100 % UVB atthe concentration of 1.7 102 mg/mL; 99 % transmittance in visible light). Moreover, OP–CDs exhibitoutstanding stability at high temperatures and different pH. With the corporation of OP–CDs and polyvinylalcohol (PVA), a high-performance UV-shielding film was formed, leading to enhanced broadspectrumUV shielding performance and improved mechanical properties, resistance of photocatalyticactivity and anti-UV aging ability compared with pure PVA film. Notably, the PVA film remains hightransparency with the addition of OP–CDs. The study suggests that the corporation of OP–CDs and polymersis effective in anti-UV degradation.