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안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2
Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.
Ji-Ye Kee,Seung-Heon Hong 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.2
Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects. However, the effect of G-Rg3 on mast cellemediated allergic inflammation has not been investigated. Method: The antiallergic effects of G-Rg3 on allergic inflammationwere evaluated using the human and rat mast cell lines HMC-1 and RBL-2H3. Antiallergic effects of G-Rg3 were detected by measuring cyclic adenosine monophosphate (cAMP), detecting calcium influx, and using real-time reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay,Western blotting, and in vivo experiments. Results: G-Rg3 decreased histamine release from activated mast cells by enhancing cAMP levels and calcium influx. Proinflammatory cytokine production was suppressed by G-Rg3 treatment via regulation of the mitogen-activated protein kinases/nuclear factor-kappa B and receptor-interacting protein kinase 2 (RIP2)/caspase-1 signaling pathway in mast cells. Moreover, G-Rg3 protected mice against the IgEmediated passive cutaneous anaphylaxis reaction and compound 48/80-induced anaphylactic shock. Conclusion: G-Rg3 may serve as an alternative therapeutic agent for improving allergic inflammatory disorders.
Hong, Ji Heon,Jang, Sung Ho The Society of Physical Therapy Science 2011 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.23 No.1
<P>[Purpose] Little is known about the detailed anatomical connections of the neural network related to hand movement in the human brain. We investigated the neural network using diffusion tensor tractography (DTT) data analyzed in conjunction with functional MRI (fMRI) activation results. [Subjects and Method] We recruited 19 healthy volunteers for this study. Probabilistic tractography was used to analyze diffusion tensor imaging (DTI) data that were collected using fMRI activation induced by grasp-release movements of the hand at a rate of 1 Hz. [Results] The brain areas connected to the primary sensorimotor cortex (SM1), which is activated by hand movements, were the premotor cortex (100%), superior parietal lobule (100%), intraparietal sulcus (100%), supramarginal gyrus (97.37%), supplementary motor area (89.47%), thalamus (86.84%), putamen (81.58%), pars opercularis (81.58%), pars triangularis (68.42%), angular gyrus (65.79%), and cerebellum (60.53%) in the same hemisphere and the contralateral primary motor cortex (60.53%) in the opposite hemisphere. No significant difference was observed in the total incidence of connected tracts between hemispheres. [Conclusion] These results reveal that more brain areas are involved in hand movements than were previously thought necessary for motor planning and execution in the human brain.</P>
A case of frontal fibrosing alopecia treated with oral alitretinoin
( Ji Young Lee ),( Jong Heon Jeong ),( Seung Ju Yun ),( Gwang Hoon Kim ),( Jong Soo Hong ),( Seung Ho Lee ),( Ai-young Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Lichen planopliaris(LPP) is a rare inflammatory cutaneous disorder selectively involving hair follicles. Frontal fibrosing alopecia(FFA) is a variant of LPP and it can be characterized by scarring alopecia of frontotemporal scalp, thinning or loss of the other facial hair, facial papules. Local corticosteroid and systemic immunomodulators can be used for treatment of FFA, but it is often difficult to manage. Alitretinoin is known to have anti-inflammatory and immune modulating efficacy. With this mechanism, there are several reports about its efficacy in the treatment of lichen planus. But there is no report about LPP treated with alitretinoin. Here we report a case of FFA treated with oral alitretinoin. A 63-year-old women presented with hair loss on the frontal hairline and sideburn of 4 months of duration. She also complained about papules on the face, scalp, trunk and extremities. On examination, band like hair loss and atrophic change occurred in the frontal area. Widespread comedones, facial papules and partial hair loss were observed in the both temporal area. Skin biopsy performed on the trunk revealed dense band-like lymphocytic infiltration on dermoepidermal junction. Based on clinicopathologic findings, her lesion was diagnosed as FFA. We tried oral alitretinoin considering the widespread comedones and therapeutic outcome in lichen planus. After 1 month of treatment, her skin lesions have been improving.
Bowen's disease associated with angiolymphoid hyperplasia with eosinophilia
( Ji Young Lee ),( Jong Heon Jeong ),( Seung Ju Yun ),( Jong Soo Hong ),( Ai Young Lee ),( Seung Ho Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vascular lesion of unknown etiology characterized by red to brown papules or nodules, usually occurring in the head and neck region. ALHE represent with a proliferation of blood vessels accompanied by a dense infiltrate of lymphocytes with eosinophils. It is regarded as a reactive process in response to tissue damage or a neoplastic process. We report a case of Bowen's disease associated with angiolymphoid hyperplasia with eosinophilia in a 55-year-old man. He presented with a 6-month history of a slowly enlarging erythematous plaque on the penile shaft.. Physical examination revealed a 1.0x0.6 cm sized erythematous plaque on the penile shaft. A skin biopsy specimen taken from the penile lesion revealed parakeratosis, acanthosis, atypical keratinocytes throughout the epidermis and proliferation of capillary structures with lichenoid infiltrate of numerous lymphocytes and eosinophils in the dermis. A diagnosis of Bowen’s disease associated with ALHE was made according to the clinical and histopathological findings. Wide local excision was performed and there was no recurrence at a 9-month follow up.