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Yoo, Joonsang,Yang, Jae Hoon,Choi, Byoung Wook,Kim, Young Dae,Nam, Hyo Suk,Choi, Hye-Yeon,Cho, Hyun-Ji,Lee, Hye Sun,Cha, Myoung-Jin,Choi, Donghoon,Nam, Chung Mo,Jang, Yangsoo,Lee, Dong Hyun,Kim, Jinkw S. Karger AG 2012 Cerebrovascular diseases Vol.33 No.3
<P>Abstract</P><P><I>Background:</I> Atherosclerosis is a systemic disease. Many ischemic stroke patients may have concomitant coronary artery disease (CAD). Detection and treatment of preclinical CAD in stroke patients may improve long-term outcome and survival because CAD is a major cause of death during follow-up in stroke patients. However, association between coronary and cerebral artery atherosclerosis in stroke patients has not fully been investigated. This study aimed at examining the frequency and high-risk groups of CAD in ischemic stroke patients. <I>Methods:</I> Consecutive patients who were admitted due to acute ischemic stroke between July 2006 and June 2010 were prospectively enrolled in this study. A total of 1,304 patients who underwent MSCT coronary angiography and cerebral angiography were included in this study. By using 64-multislice computed tomography coronary angiography, we investigated the frequency of CAD and association between coronary and cerebral artery atherosclerosis in terms of location and burden (severity and extent) in stroke patients. We also sought to identify high-risk groups for CAD among stroke patients. <I>Results:</I> The frequency of significant (≥50%) CAD was 32.3% and the frequency of any degree of CAD was 70.1%. Diabetes mellitus, serum levels of total cholesterol, high-density lipoprotein cholesterol and triglyceride, and significant stenosis of the extracranial carotid, intracranial vertebral and basilar arteries were independently associated with CAD. However, no association was found between CAD and significant stenosis of the anterior, middle and posterior cerebral arteries. The association between CAD and cerebral atherosclerosis was stronger with increased severity and extent of cerebral atherosclerosis. When compared to patients with <2 risk factors and without significant cerebral atherosclerosis, those with multiple (≥2) risk factors and atherosclerosis in both the carotid and the vertebrobasilar arteries had very high risks of CAD [odds ratio (OR) 8.36; 95% confidence interval (CI) 4.15–16.87]. The risk was also high in patients with multiple risk factors and atherosclerosis in either the carotid or the vertebrobasilar artery (OR 4.13; 95% CI 2.62–6.51), and in those with <2 risk factors but atherosclerosis in both the carotid and the vertebrobasilar arteries (OR 3.40; 95% CI 1.22–9.47). <I>Conclusions:</I> A substantial portion of stroke patients had preclinical CAD, and there was a clear relationship between coronary and cerebral artery atherosclerosis in terms of location and burden. The risk of CAD was particularly high in stroke patients with multiple risk factors and atherosclerosis of the carotid and/or vertebrobasilar arteries.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
Ji, Young Su,Chung, Sung Jae,Ok, Myoung-Ryul,Hong, Kyung Tae,Suh, Jin-Yoo,Byeon, Jai Won,Yoon, Jin-Kook,Lee, Kyung Hwan,Lee, Kyung Sub Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>The crystallization behavior of Cu<SUB>43</SUB>Zr<SUB>43</SUB>Al<SUB>7</SUB>Ag<SUB>7</SUB> (numbers indicate at.%) bulk metallic glass was investigated using the isothermal electrical resistivity measurements at 450°C in the supercooled liquid region. The crystallization process is a single step phase transformation. To analyze the electrical resistivity reduction, microstructure evolutions were analyzed using differential scanning calorimetry, X-ray diffraction, transmission electron microscopy and small-angle X-ray scattering. The Avrami parameter of the electrical resistivity reduction step was 1.73, indicating that the crystallization process is a diffusion-controlled growth of intermetallic compounds with decreasing nucleation rate.</P>
Yoo, Jae-Min,Park, Young W.,Yoon, Sun Young,Son, Ji Yoon,Jeong, Seok Geun,Park, Beom-Young,Kim, Jae Wha,Nam, Myoung Soo American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.50
<P>α-Lactalbumin and β-lactoglobulin are two major whey proteins that specifically bind immunoglobulin E and are suspected as major allergens causing cow’s milk allergy (CMA). Recent studies have shown that thymic stromal lymphopoietin is a critical factor linking at the interface of the body and environment to the T-helper 2 response. However, it is not known whether thymic stromal lymphopoietin expression is changed by α-lactalbumin and β-lactoglobulin in immune cells. Using RT-PCR and ELISA, the present study was conducted to examine if intravenous injection of α-lactalbumin and β-lactoglobulin increased pro-inflammatory cytokines, T-helper 2 cytokines, and thymic stromal lymphopoietin expression in several immune cells, including macrophages, mast cells, and keratinocytes. Results showed that α-lactalbumin and β-lactoglobulin induced thymic stromal lymphopoietin, interleukin-6, and tumor necrosis factor-α expression. It was concluded that the allergenicity of α-lactalbumin and β-lactoglobulin may be attributed to thymic stromal lymphopoietin induction, T-helper 2 cytokines, and pro-inflammatory cytokines.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-50/acs.jafc.5b04790/production/images/medium/jf-2015-04790n_0007.gif'></P>
Streptococcus parasanguinis에 의한 폐렴과 부폐렴성 흉수
박명린 ( Myoung Rin Park ),박동일 ( Dong Il Park ),유수진 ( Su Jin Yoo ),정선영 ( Sun Young Jung ),은혁수 ( Hyuk Soo Eun ),김민정 ( Min Jung Kim ),박지원 ( Ji Won Park ),박희선 ( Hee Sun Park ),정성수 ( Sung Soo Jung ),김주옥 ( Ju 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5
Streptococcus parasanguinis is a Viridans group bacteria that is most often discovered in the oral cavity and causes dental plaque and endocarditis in a rat model. It has low virulence but an unknown relationship to human respiratory infections. We report on a 61-year-old woman who developed hemoptysis followed by pleuritic chest pain after conscious sedation during a gastroscopic polypectomy and was diagnosed with pneumonia and parapneumonic effusion from Streptococcus parasanguinis isolated in pleural fluid. Microaspiration during the procedure was presumed to play a role in the pathogenesis.