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        문복희(Fu Ji Wen),박영권(Young?Kwon Park),유경선(Kyung?Seun Yoo) 한국실내환경학회 2008 한국실내환경학회지 Vol.5 No.3

        The interest of natural chemicals has been increased because of inflection of endocrine disruptor and fatal health danger originated from artificial chemical compounds. The essential oil is one of the representative natural chemicals which can be collected from the most plants and can be applied to high value­added merchandise such as the antiseptics, anti­oxidants and deodorants. In this study, essential oil was testified to remove odor such as NH3. In case of the essential oil of a pine leaf, removal efficiency of NH₃ was about 100%. The NH₃ removal efficiency of the mixed solution (mixture of essential oil and ethanol) was slightly lower than that of pure essential oil and this leads to the conclusion that use of mixture is more economical and effective to control the odor.

      • KCI등재
      • KCI등재

        한국 제천 감초(Glycyrrhiza uralensis Fisher)의 추출 조건별 추출물의 항산화 및 항균 활성 평가

        하지훈 ( Ji Hoon Ha ),정윤주 ( Yoon Ju Jeong ),성준섭 ( Joon Seob Seong ),김경미 ( Kyoung Mi Kim ),김아영 ( A Young Kim ),부민민 ( Min Min Fu ),서지영 ( Ji Young Suh ),이난희 ( Nan Hee Lee ),박진오 ( Jino Park ),박수남 ( Soo Nam P 대한화장품학회 2015 대한화장품학회지 Vol.41 No.4

        본 연구는 한국 제천에서 재배된 감초(Glycyrrhiza uralensis Fisher, G. uralensis)를 대상으로 추출 조건(85% 에탄올, 추출 온도 및 시간)별로 추출한 추출물에 대하여 항산화 활성 및 항균 활성을 측정하고 이로부터 최적의 추출 조건을 선정하여 감초 추출물을 화장품 원료로 개발하기 위한 제조 공정에 활용하고자 하였다. 실험에 사용한 시료는, 각 추출 조건에서 얻어진 추출물을 농축하여 분말로 한 시료(시료-1)와 추출물을 농축하지 않고 추출물 원액을 그대로 사용한 시료(시료-2)이다. 항산화 활성은 라디칼 소거활성, 총항산화능, 활성산소로 유도된 세포손상에서 세포보호효과를 측정하였다. 항균 활성은 피부 상재균에 대한 최소저해농도를 측정하였다. 1,1,-Diphenyl-2-picrylhydrazyl를 이용한 라디칼 소거활성에서, 시료-1은 100 μg/mL에서 추출시간이 6 h일 때가 12 h일 때보다 약 10% 정도 더 큰 라디칼 소거활성을 나타냈다. 반면에 시료-2의 라디칼 소거활성은 추출 시간에 따른 유의적 차이를 나타내지 않았다. 한편 동일 온도에서 12 h 추출한 추출물의 수율은 6 h 추출한 경우의 수율보다 2.6배 더 컸다. 하지만 총 플라보노이드 함량은 1.1배 정도 더 크게 나타났다. 따라서 추출 시간이 길어도 총플라보노이드 함량은 거의 증가하지 않았음을 보여준다. 추출 조건별 감초 추출물의 라디칼 소거활성, 총항산화능 및 세포보호효과가 추출물의 수율을 반영한 것이 아니라 추출물 중에 함유된 총플라보노이드 함량에 의존함을 나타내고 있다. 피부 상재균에 대한 항균 활성은 추출 조건별 동일 농도(시료-1)에서 측정했을 때, 세 균주(S. aureus, B. subtilis, P. acnes)에 대해 25 및 40 ℃에서 추출된 감초추출물(156 μg/mL)은 methyl paraben (2,500 μg/mL)보다 약 16배 정도로 매우 큰 항균 활성을 나타냈다. 결론적으로 항산화 활성 및 항균 활성이 큰 감초 추출물의 최적 추출 조건은 85% 에탄올로 40 ℃에서 6 h 추출한 추출물이 최적임을 확인할 수 있었다. 본 연구 결과, 화장품에 항산화 활성 및 항균 활성이 큰 감초 추출물을 원료화하기 위해서는 추출 조건별 추출물의 수율, 활성 성분의 수율, 추출물의 농도별 활성 평가와 추출 수율이 반영된 추출물 원액 자체의 활성을 종합 평가해서 추출 조건을 선정해서 원료의 제조 공정에 반영하는 것이 중요함을 시사한다. This study was carried out to evaluate the antioxidant and antibacterial activities of Glycyrriza uralensis Fisher (Jecheon, Korea) extracts obtained by various extraction conditions (85% ethanol, heating temperatures and times), and to establish the optimal extraction condition of G. uralensis for the application as cosmetic ingredients. The extracts obtained under different conditions were concentrated and made in the powdered (sample-1) and were the crude extract solutions without concentration (sample-2). The antioxidant effects were determined by free radical scavenging activity (FSC50), ROS scavenging activity (OSC50), and cellular protective effects. Antibacterial activity was determined by minimum inhibitory concentration (MIC) on human skin flora. DPPH free radical scavenging activity of sample-1 (100 μg/mL) was 10% higher in group extracted for 6 h than 12 h, but sample-2 didn’t show any significant differences. The extraction yield extracted with same temperature for 12 h was 2.6 times higher than 6 h, but total flavonoid content was 1.1 times higher. These results indicated that total flavonoid content hardly increased with increasing extraction time. Free radical scavenging activity, ROS scavenging activity and cellular protective effects were not dependent on the yield of extraction, but total flavonoid content of extraction. Antibacterial activity on three skin flora (S. aureus, B. subtilis, P. acnes)of sample-1 in different extraction conditions were evaluated on same concentration, and the group extracted at 25 and 40 ℃ showed 16 times higher than methyl paraben (2,500 μg/mL). In conclusion, 85% ethanol extracts of G. uralensis extracted at 40 ℃ for 6 h showed the highest antioxidant and antibacterial activity. These results indicate that the extraction condition is important to be optimized by comprehensive evaluation of extraction yield with various conditions, yield of active component, and activity test with concentrations, and activity of 100% extract, for manufacturing process of products.

      • SCISCIESCOPUS
      • KCI등재

        NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO

        FU-DE WANG,Ying Tang,Yong Ji Yang,CHAN JIN,HUA ZHANG,HAO LIANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2

        Multiwall carbon nanotubes (MWCNTs) have been widely applied in many ¯elds due to theexcellent physical and chemical properties. As the production and applications of nanotubesexpand, public concern about their potential risks to human health has also raised. Cytotoxicityof MWCNTs was evaluated in this study using a cultured human epithelial cell line A549. Uptakeof MWCNTs by cultured A549 cells was observed by TEM imaging. Dose-dependent decrease ofcell viability showed the cytotoxicity of MWCNTs. Signi¯cant reactive oxygen species (ROS)generation and GSH depletion which reduced the cellular antioxidant level could be the majorfactor of cytotoxicity induced by MWCNTs. MWCNTs seemed to trigger the activation of cellautophagy with the intracellular ATG16L1 level increase as a defense mechanism.

      • KCI등재

        The electronic and magnetic properties with intrinsic defects in ZnO nanosheets: First-principles prediction

        Fu-Bao Zheng,Chang-Wen Zhang,Pei-Ji Wang,Hang-Xing Luan 한국물리학회 2013 Current Applied Physics Vol.13 No.4

        Using full-potential linearized augmented plane wave (FLAPW) method, we investigated the effects of intrinsic vacancies on electronic and magnetic properties in graphene-like ZnO nanosheets. The results show that the oxygen vacancy (VO) has no influence on magnetism in ZnO nanosheet, whereas the Zn vacancy (VZn) lead to spin polarization of the nanostructures with a total magnetic moment of 2.0mB due to O-2p and Zn-3d hybridization. When the distance of two VZn defects increases to 6.499 A, the system shows an intriguing half-metallic character with 100% spin-polarized carriers due to O(2p)-Zn(3d)-O(2p) coupling chain between two VZn defects.

      • KCI등재

        Study of the Flow Behavior and Defect Formation in Forming of Axisymmetrically Flanged and Multi-Scaled Parts

        Ji Lai Wang,Ming Wang Fu,Junxi Yu,Xing Wang,Wenbin Yang 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.10

        In microforming, the quality of microparts is one of the most critical issues. Folding caused by the abnormal material flow is one of the most common flow-induced defects in macroforming process. The identified formation mechanism of flow-induced defects in macro-forming process could be affected by the so-called size effects when the part dimension is scaled down to micro scale. Therefore, it is necessary to investigate the influence of size effects on the material plastic flow and deformation behavior in multiscaled deformation scenarios. To explore the formation mechanism of flow-induced defects, FE simulation is used to simulate the forming process. On the other hand, the multi-scaled forming was designed. To study the relationship of the flow-induced defect and sizes effects, forming of the axisymmetric parts with flanged features and different scales was conducted. The microstructure and plastic flow behavior of the deformed parts are also revealed. Based on the experimental and FEM simulation results, the formation of folding defects is mainly affected by the geometries and the sizes of the deformed flanged parts instead of grain sizes. In the cases by using material with coarse grains, the folding defect can be significantly reduced.

      • The Malleability of Culture and Leadership Style in East Asia

        Ji Li,Ping Ping Fu,Zhiqiang Liu,Y.Y. Chen 한국조직경영개발학회 2008 조직경영개발연구 Vol.1 No.1

        글로별 리더십과 조직행동유효성 프로그램 (GLOBE) 의 데이터를 분석하여 우리는 동아시아 국가들 사이에 문화와 리더십 스타일에 차이가 있다는 것을 발견하였다. 이런 차이를 설명하기 위하여 우리는 새로운 이론적 관점인 제도적 공생이라는 관점을 개발하였다. 생물학의 개념에 해당되는 이 제도적 공생의 관점은 상이한 개체 또는 종들이 어떻게 제도적 환경을 포함한 어떤 환경에서 함께 살아가게 되는지를 설명한다. 이 새로운 관점은 제도파 이론에서 보이는 한계들을 극복할 수 있게 한다. 또한 사회문화와 합법적 리더십 스타일을 포함한 사회제도의 동태적인 성격을 이해하는데 도움을 준다. 이 새로운 개념이 학자와 실무자들에게 주는 시사점으로 결론을 맺었다. Analyzing the data collected for the Global Leadership and Organizational Behavior Effectiveness Program (GLOBE), we found some interesting differences in culture and leadership style among economies in East Asia. To explain these differences, we develop a new theoretical perspective, institutional symbiosis. Developed from a similar concept in biology, the perspective of institutional symbiosis describes how different species or elements closely living together in a certain environment, including institutional environment. This new perspective helps overcome some limitations in the current literature of institutional theory. It can also improve our understanding of the dynamic nature of social institutions, including societal cultures and legitimate leadership style. The paper concludes with a discussion on the implications of this new perspective for researchers and practitioners.

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