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- 저자 : Jha, Manis Kumar (검색결과 314 건)
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DRAG REDUCTION OF A PICKUP TRUCK BY A REAR DOWNWARD FLAP
J. HA,S. JEONG,S. OBAYASHI 한국자동차공학회 2011 International journal of automotive technology Vol.12 No.3
The drag reduction of a pickup truck by a rear flap add-on was examined through CFD simulations and wind tunnel experiments. When installed at the rear edge of the roof, the flap increased the cabin back surface pressure coefficient, causing the downwash of the bed flow to be inclined on the tailgate. Thus, the attachment of the bed flow to the tailgate was eliminated; consequently, the drag coefficient was reduced with increasing flap length and downward angle despite the enlarged reverse flow in the wake. However, the drag coefficient did not decrease any further after a specific downward angle was reached because the bed flow increased the drag force at the tailgate and the flap lowered the pressure field above the flap. To maximize the drag reduction effect, the rear downward flap should be designed to have an optimum downward angle.
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J. HA,허훈,J. H. SONG,J. H. LIM 한국자동차공학회 2013 International journal of automotive technology Vol.14 No.1
This paper proposes a new equivalent failure strength model for spot welds under combined axial and shear loading. To evaluate the pure-shear strength of spot welds fabricated under the same welding conditions with a two-layered lap joint, a test fixture and a specimen were newly designed and proposed. The failure tests of spot welds of TRIP590 1.2t,DP780 1.0t, DP780 1.2t, and DP980 1.2t were carried out at seven different loading angles ranging from 0o to 90o at an internal angle of 15o to obtain the failure loads. The failure loads obtained from the experiments were utilized to construct the failure criterion and thus describe the failure behavior of spot welds in the crash analysis or strength analysis of an auto-body. It is noted that the value of β in the failure criterion for spot welds of AHSS is different from the values of conventional steels. The new equivalent failure strength model proposed in this paper was derived from the failure test results to provide a representative failure model that can be used to accurately compare the failure characteristics of different materials under the same conditions.
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정신분열병 환자의 임상반응에 따른 혈장 Homovanillic Acid와 혈장 할로페리돌의 변화
구자일,오동열,양병환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.1
Nineschizophrenic inpatients were studied under halopendol treatment for the purpose of evaluating the possible correlation between plasma HVA, leuels(P-HVA) plasma halopendol levels (P-haloperidal) and clinical symptom changes. The authors measured plasma HVA and plasma haloperidol levels, and checked BPRS and SAPS scores at baseline, 7th day. 28th day and 56th day of treatment. 1) P-HVA concentrations of total patients were highest on 7th day, then returned to baseline levels on 28th day. but that of drug responder group(6 patients) were highest on pretreatment then decreased below baseline levels on 7th day and continued to decrease till 56th day of treatment. 2) P-HVA concentrations of total patients showed positive correlations with BPRS scores (r=0.28, p<0.l) and-with SAPS scores(r=0.36, p<0.05) and that of drug responder group showed also positive correlations with BPRS scores(r=0.24, p=NS) and with SAPS scores (r=0.45. p<0.0l). 3) P-haloperidol concentrations of total patients showed significant positive correlation with haloperidol doses(r=0.73, p<0.00l) and that of drug responder group showed positive correlation with haloperidol doses(r=0.53. P<0.01). P-haloperidol concentration of drug responder group showed significant negative correlation with BPRS scores(-0.72, P<0.01) and with SAPS scores(-0.59. P<0.001) but that of total patients did not. 4) The haloperidol doses of drug responder group showed meaningful negative correlations with P-HVA(r=-0.38. p=0.03) and with BPRS scores (r=-0.50. P<0.01) and with SAPS scores(r=-0.47. p=0.0l) but that of total patients did not. The authors discussed the meaning of above results.
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Pankaj Kumar Jha,Saroj Sapkota,Neena Amatya Gorkhali,Bhoj Raj Pokharel,Ajeet Kumar Jha,Shishir Bhandari,Bhola Shankar Shrestha 사단법인 한국동물생명공학회 2019 한국동물생명공학회지 Vol.34 No.4
The study was conducted to evaluate the seminal attributes and cryo-banking of Achhami (Bos indicus) bull semen. Of two Achhami bulls, 8 ejaculates from each bull were evaluated for seminal attributes. For semen freezing and cryo-banking, 4 ejaculates (having ≥2 mL semen volume, ≥75% of sperm motility and ≥1,000 × 106 cells/mL of sperm concentration) from each bull were used. Semen samples were diluted in egg-yolk-tris-citrate extender using a two-step dilution protocol, and were frozen in liquid nitrogen (LN2) vapour in a styrofoam box. The mean semen volume, colour, sperm mass activity, motility, viability, concentration, abnormal acrosome, midpiece and tail and, abnormal head of two Achhami bulls were 4.4 ± 0.5 mL vs. 2.5 ± 0.2 mL, 2.5 ± 0.1 vs. 2.4 ± 0.1, 3.5 ± 0.1 vs. 3.5 ± 0.1, 77.0 ± 1.1% vs. 78.3 ± 1.3%, 94.4 ± 0.5% vs. 91.0 ± 0.6%, 1137.7 ± 73.7 × 106 cells/mL vs. 1060.0 ± 44.3 × 106 cells/mL, 10.2 ± 0.5% vs. 10.3 ± 0.5% and 6.7 ± 0.5% vs. 8.2 ± 0.3%, respectively. The post-thawed sperm motility and viability were 53.0 ± 2.0% vs. 50.0 ± 0.0% and 80.2 ± 0.4% vs. 73.2 ± 0.7%, while evaluating by computer-assisted sperm analysis (CASA) system, the percentage of the progressive motility, fast motility, slow motility, local motility and immotile sperm were 75%, 68%, 7.4%, 16.6% and 8.6%, respectively. A total number of 620 doses semen straw were cryo-banked. Due to the acceptable post-thawed sperm motility and viability recorded, cryopreservation of Achhami semen is hereby recommended so as to preserve the Achhami breed. For further validation, the fertility will be observed from the produced frozen semen.
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Priyanka A. Jha,A.K. Jha 한국물리학회 2013 Current Applied Physics Vol.13 No.7
In the present study, structural, dielectric and ferroelectric properties of Ba1-3x/2Yx Zr0.025Ti0.975O3ferroelectric ceramics have been investigated. The compound was synthesized using solid state reaction technique. The effect of yttrium substitution on structural, dielectric and ferroelectric properties was studied using X-ray diffractometer, scanning electron microscopy (SEM), LCR meter and PeE loops. Phase analysis shows the formation of secondary phase YTi2O6 for Y ≥ 2.5 mol% substitution. The microstructural investigation shows that Y substitution significantly reduces the grain size. An increase in Y content up to 2.5 mol% increases the Curie temperature (Tc) initially but decreases subsequently. The maximum dielectric constant at Tc has been observed for 2 mol% Y substitution and with further increase in Y content the dielectric constant decreases considerably. The solubility limit is found to be 2.5 mol% of Y and after that some of the yttrium atoms enter B-sites and leading to the formation of the secondary phase. The PeE loop studies show that there is an increase in the coercive field with increasing Y content.
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Pankaj Kumar Jha,Saroj Sapkota,Neena Amatya Gorkhali,Bhoj Raj Pokharel,Ajeet Kumar Jha,Shishir Bhandari,Bhola Shankar Shrestha 한국동물생명공학회(구 한국동물번식학회) 2019 Journal of Animal Reproduction and Biotechnology Vol.34 No.4
The study was conducted to evaluate the seminal attributes and cryo-banking of Achhami (Bos indicus) bull semen. Of two Achhami bulls, 8 ejaculates from each bull were evaluated for seminal attributes. For semen freezing and cryo-banking, 4 ejaculates (having ≥2 mL semen volume, ≥75% of sperm motility and ≥1,000 × 106 cells/mL of sperm concentration) from each bull were used. Semen samples were diluted in egg-yolk-tris-citrate extender using a two-step dilution protocol, and were frozen in liquid nitrogen (LN2) vapour in a styrofoam box. The mean semen volume, colour, sperm mass activity, motility, viability, concentration, abnormal acrosome, midpiece and tail and, abnormal head of two Achhami bulls were 4.4 ± 0.5 mL vs. 2.5 ± 0.2 mL, 2.5 ± 0.1 vs. 2.4 ± 0.1, 3.5 ± 0.1 vs. 3.5 ± 0.1, 77.0 ± 1.1% vs. 78.3 ± 1.3%, 94.4 ± 0.5% vs. 91.0 ± 0.6%, 1137.7 ± 73.7 × 106 cells/mL vs. 1060.0 ± 44.3 × 106 cells/mL, 10.2 ± 0.5% vs. 10.3 ± 0.5% and 6.7 ± 0.5% vs. 8.2 ± 0.3%, respectively. The post-thawed sperm motility and viability were 53.0 ± 2.0% vs. 50.0 ± 0.0% and 80.2 ± 0.4% vs. 73.2 ± 0.7%, while evaluating by computer-assisted sperm analysis (CASA) system, the percentage of the progressive motility, fast motility, slow motility, local motility and immotile sperm were 75%, 68%, 7.4%, 16.6% and 8.6%, respectively. A total number of 620 doses semen straw were cryo-banked. Due to the acceptable post-thawed sperm motility and viability recorded, cryopreservation of Achhami semen is hereby recommended so as to preserve the Achhami breed. For further validation, the fertility will be observed from the produced frozen semen.
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Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders
Jha, M.K.,Lee, W.H.,Suk, K. Pergamon Press 2016 Biochemical pharmacology Vol.103 No.-
<P>Recent neuroscience research has established the adult brain as a dynamic organ having a unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes, provide dynamicity to the brain. Activation of these glial cells is a major component of the neuroinflammatory responses underlying brain injury and neurodegeneration. Glial cells execute functional reaction programs in response to diverse microenvironmental signals manifested by neuropathological conditions. Activated microglia exist along a continuum of two functional states of polarization namely M1-type (classical/proinflammatory activation) and M2-type (alternative/anti-inflammatory activation) as in macrophages. The balance between classically and alternatively activated microglial phenotypes influences disease progression in the CNS. The classically activated state of microglia drives the neuroinflammatory response and mediates the detrimental effects on neurons, whereas in their alternative activation state, which is apparently a beneficial activation state, the microglia play a crucial role in tissue maintenance and repair. Likewise, in response to immune or inflammatory microenvironments astrocytes also adopt neurotoxic or neuroprotective phenotypes. Reactive astrocytes exhibit two distinctive functional phenotypes defined by pro- or anti-inflammatory gene expression profile. In this review, we have thoroughly covered recent advances in the understanding of the functional polarization of brain and peripheral glia and its implications in neuroinflammation and neurological disorders. The identifiable phenotypes adopted by neuroglia in response to specific insult or injury can be exploited as promising diagnostic markers of neuroinflammatory diseases. Furthermore, harnessing the beneficial effects of the polarized glia could undoubtedly pave the way for the formulation of novel glia-based therapeutic strategies for diverse neurological disorders. (C) 2015 Elsevier Inc. All rights reserved.</P>
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Jha, Pankaj Kumar,Paul, Ashit Kumar,Rahman, M. Bozlur,Tanjim, M.,Bari, Farida Yeasmin,Alam, M. Golam Shahi The Korean Society of Embryo Transfer 2013 한국동물생명공학회지 Vol.28 No.1
Alpha-tocopherol as an antioxidant acts in preservation of chilled semen by preserving cell membrane damage from lipid peroxidation. Optimum concentrations of ${\alpha}$-tocopherol in egg yolk-citrate (EYC) extender need to be studied in crossbred bull's semen. Different concentrations of ${\alpha}$-tocopherol viz. 0, 1, 2, 4 and 6mg per ml of extender were used. Semen was collected once a week from four bulls used to regular collection, aged 4 to 7 years, weighing 320 to 450 kg, and with body condition score 4 to 4.5 and scrotal circumference 23 to 32 cm. Semen was evaluated routinely and sperm morphology was viewed under light microscope at ${\times}1,000$ magnification after fixing with buffered formal saline. Over 90% had normal head, acrosome, mid-piece and tail. Semen was diluted with egg-yolk-citrate extender to produce $15{\times}10^6$ spermatozoa/ml and 0, 1, 2, 4 and 6 mg/ml ${\alpha}$-tocopherol were added. The semens amples were kept at $8^{\circ}C$. Sperm motility and viability were examined daily up to 5 days under light microscopy at ${\times}200$ magnification. Sperm viability was acceptable (${\geq}40%$) up to the $4^{th}$ day with all concentrations of ${\alpha}$-tocopherol and up to the $5^{th}$ day with 2 mg/ml ${\alpha}$-tocopherol. Sperm motility was acceptable (${\geq}40%$) up to the $3^{rd}$ day irrespective of ${\alpha}$-tocopherol concentration, and up to the $4^{th}$ day with 2 mg/ml ${\alpha}$-tocopherol. It is suggested that the lifespan of chilled semen may be extended up to 4 days by adding 2mg/ml ${\alpha}$-tocopherol.
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Glia as a Link between Neuroinflammation and Neuropathic Pain
Jha, Mithilesh Kumar,Jeon, Sang-Min,Suk, Kyoung-Ho The Korean Association of Immunobiologists 2012 Immune Network Vol.12 No.2
Contemporary studies illustrate that peripheral injuries activate glial components of the peripheral and central cellular circuitry. The subsequent release of glial stressors or activating signals contributes to neuropathic pain and neuroinflammation. Recent studies document the importance of glia in the development and persistence of neuropathic pain and neuroinflammation as a connecting link, thereby focusing attention on the glial pathology as the general underlying factor in essentially all age-related neurodegenerative diseases. There is wide agreement that excessive glial activation is a key process in nervous system disorders involving the release of strong pro-inflammatory cytokines, which can trigger worsening of multiple disease states. This review will briefly discuss the recent findings that have shed light on the molecular and cellular mechanisms of glia as a connecting link between neuropathic pain and neuroinflammation.
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