3D-CT를 이용한 골격성 III급 개방교합자의 악교정 수술 전, 후 설골 및 상기도의 변화

이윤섭,백형선,이기준,유형석 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.2

본 연구는 골격성 III급 개방교합자의 악교정 수술 전, 후 설골과 상기도의 변화를 3D-CT를 이용하여 관찰하고 이를 정상교합자와 비교하기 위하여 시행하였다. 전치부 개방교합을 동반한 골격성 III급 부정교합으로 진단되어 악교정 수술을 받은 환자 중 12명을 선정 후, 3D-CT를 통해 설골과 상기도의 3차원 입체영상을 분석하여, 악교정 수술 전, 후의 설골의 위치 변화 및 상기도의 부피 변화를 살펴보고, 이의 결과를 정상교합자 10명과 비교하였다. 설골은 골격성 III급 개방교합군에서 악교정 수술 전에 정상교합군의 설골에 비해 전방에 위치하고 있었고 악교정 수술 후 설골은 후, 상방으로 변화하였으나 유의성은 관찰되지 않았다. Hyoid plane과 mandibular plane이 이루는 각은 악교정 수술 전의 골격성 III급 개방교합군이 정상교합군보다 큰 값을 나타내었고, 악교정 수술 후에는 그 차이가 더욱 증가하였다. 골격성 III급 개방교합군의 상기도 부피는 정상교합자보다 작으며 이는, 악교정수술 후에 더욱 감소하였다. 3차원 영상 분석 결과, 골격성 III급 개방교합자의 상기도는 정상교합자에 비해 좁으며, 하악골 후퇴술 이후 더욱 감소하기 때문에 이는 수술적 개선의 안정성에 영향을 줄 수 있음을 알 수 있었다. Objective: The purpose of this study was to investigate the structural changes of the hyoid bone and upper airway after orthognathic surgery for skeletal class III anterior open bite patients, and make comparisons with normal occlusion. Methods: Pre- and post-operative computed tomography (CT) examinations were performed on 12 skeletal class III anterior open bite patients who were treated with mandibular setback osteotomy. Using the V-works 4.0 program, 3-dimensional images of the total skull, mandible, hyoid bone, and upper airway were evaluated. Results: In the Class III openbite group, the hyoid bone were all positioned anteriorly, compared to the Normal group (p < 0.05). The angle between the hyoid plane and mandibular plane in the Class III openbite group before surgery was greater than in the Normal group (p < 0.05), and the difference increased after surgery (p < 0.01). In the Class III openbite group, the volume of the upper airway decreased after surgery (p < 0.001) and the volume of the upper airway was smaller than the Normal group before and after surgery (p < 0.001). Conclusions: The narrow upper airway space in skeletal Class III openbite patients decreased after mandibular setback osteotomy. This may affect the post-surgical stability.

직장항문 농양과 치루에 대한 임상적 고찰

김준호,서준하,이석환,이기형,윤충 경희대학교 1997 慶熙醫學 Vol.13 No.4

골다공증 척추 골절에서 전방 감압술 및 기기 이용 전방 유합술

하기용,류승준,윤형문 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

Changes in Gallbladder Motility in Gastrectomized Patients

Joon Soo Hahm,Joon Yong Park,Yun Ju Cho,Chang Soo Eun,Yong Wook Lee,Ho Soon Choi,Byoeng Chul Yoon,Min Ho Lee,Choon Suhk Kee,Kyung Nam Park,Heon Kil Lim,Sung Joon Kwon 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.1

Objectives: Gastric resection may predispose gallstone formation. However, the mechanism has not been clearly understood. To evaluate the relationship between gastric resection and gallstone formation, we compared gallbladder(GB) motility in gastrectomized

Relation Between F-18 FDG Uptake of PET/CT and <i>BRAFV</i> 600E Mutation in Papillary Thyroid Cancer

Yoon, Seokho,An, Young-Sil,Lee, Su Jin,So, Eu Young,Kim, Jang-Hee,Chung, Yoon-Sok,Yoon, Joon-Kee Wolters Kluwer Health 2015 Medicine Vol.94 No.48

<P><B>Abstract</B></P><P><I>BRAFV</I>600E mutation and F-18 fluorodeoxyglucose (FDG) uptake are potential prognostic factors of papillary thyroid cancer (PTC). This study was performed to investigate the relationship between the <I>BRAFV</I>600E mutation and F-18 FDG uptake in PTC.</P><P>We retrospectively included 169 PTC patients who underwent F-18 FDG positron emission tomography/computed tomography (PET/CT) before thyroidectomy from May 2009 to August 2012. Subjects were classified into overt PTC (>1 cm, n = 76) and papillary thyroid microcarcinoma (PTMC, n = 93) groups. Univariate and multivariate analyses were performed to assess the relationship between maximum standardized uptake value (SUV<SUB>max</SUB>) of the primary tumors and clinicopathologic variables.</P><P>The <I>BRAFV</I>600E mutation was detected in 82.2% (139/169). In all subjects, the <I>BRAFV</I>600E mutation and tumor size were independently related to SUV<SUB>max</SUB> by multivariate analysis (<I>P</I> = 0.048 and <I>P</I> < 0.001, respectively). SUV<SUB>max</SUB> was significantly higher in tumors with the <I>BRAFV</I>600E mutation than in those with wild-type <I>BRAF</I> (9.4 ± 10.9 vs 5.0 ± 4.1, <I>P</I> < 0.001). Similarly, in overt PTC group, the <I>BRAFV</I>600E mutation and tumor size were independently correlated with SUV<SUB>max</SUB> (<I>P</I> = 0.032 and <I>P</I> = 0.001, respectively). By contrast, in PTMC group, only tumor size was significantly associated with SUV<SUB>max</SUB> (<I>P</I> = 0.010).</P><P>The presence of the <I>BRAFV</I>600E mutation is independently associated with high F-18 FDG uptake on preoperative PET/CT in patients with overt PTC, but this relationship was not evident in PTMC. This study provides a better understanding of the relationship between F-18 FDG uptake and <I>BRAFV</I>600E mutation in patients with PTC.</P>

Effects of Theophylline on Radioiodide Uptake in MCF-7 Breast Cancer and NIS Gene-Transduced SNU-C5 Colon Cancer Cells

Yoon, Joon-Kee,Park, Bok-Nam,Paik, Jin-Young,Jung, Kyung-Ho,Ko, Bong-Ho,Lee, Kyung-Han Mary Ann Liebert 2009 Cancer Biotherapy & Radiopharmaceuticals Vol.24 No.2

<P>BACKGROUND: We investigated whether theophylline has the potential to increase radioiodide uptake in nonthyroidal cancer cells. MATERIALS AND METHODS: MCF-7 cells that express endogenous sodium/iodide symporter (NIS) and SNU-C5 cells adenovirally transduced with the human NIS gene (SNU-C5/NIS) were treated with 10(-7)-2x10(-4) mol/L theophylline for 24 hours before incubation with (125)I, and then, radioiodide uptake and retention were measured. NIS expression was assessed by immunohistochemistry and Western blot analysis, using an antihuman NIS monoclonal antibody. RESULTS: Theophylline at 10(-6)-2x10(-4) mol/L significantly and dose dependently augmented radioiodide uptake in MCF-7 cells and at 10(-6)-10(-5) mol/L in SNU-C5/NIS cells, without affecting radioiodide efflux. Abrogation by KClO(4)(-) demonstrated that the effect of theophylline occurred through specific iodide transport. Immunohistochemistry revealed dose-dependent increases of NIS staining in MCF-7 and SNU-C5/NIS cells by 10(-6)-10(-4) and 10(-6)-10(-5) mol/L theophylline, respectively. Western blot analysis demonstrated similar findings, showing increased expression of NIS on the membrane of SNU-C5/NIS and MCF-7 cells by theophylline treatment. CONCLUSIONS: Theophylline can augment radioiodide uptake in breast cancer cells and NIS gene-transduced cancer cells through the upregulation of NIS expression. Therefore, further investigations are warranted to explore the potential utility of this phenomenon for enhancing radioiodide-based imaging and therapies of NIS gene-transduced cancer cells.</P>

정상적인 노화 과정에서 국소뇌포도당대사의 변화 : FDG PET 연구

윤준기(Joon Kee Yoon),김상은(sang Eun Kim),이경한(Kyung Han Lee),최용(Yong Choi),최연성(Yearn Seong Choe),김병태(Byung Tae Kim) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.4

N/A Purpose: Normal aging results in detectable changes in the brain structure and function. We evaluated the changes of regional cerebral glucose metabolism in the normal aging process with FDG PET. Materials and Methods: Brain PET images were obtained in 44 healthy volunteers (age range 20-69 ‘y’: M:F = 29:15) who had no history of neuropsychiatric disorders. On 6 representative transaxial images, Rols were drawn in the cortical and subcortical areas. Regional FDG uptake was normalized using whole brain uptake to adjust for the injection dose and correct for nonspecific declines of glucose metabolism affecting all brain areas equally. Results: In the prefrontal, temporoparietal and primary sensorimotor cortex, the normalized FDG uptake (NFU) reached a peak in subjects in their 30s. The NFU in the prefrontal and primary sensorimotor cortex declined with age after 30s at a rate of 3.15%/decade and 1.93%/decade, I'6Spectively. However, the NFU in the temporoparietal cortex did not change significantly with age after 30s. The anterior (prefrontal) posterior (temporoparietal) gradient peaked in subjects in their 30s and declined with age thereafter at a rate of 2.35%/decade. The NFU in the caudate nucleus was decreased with age after 20s at a rate of 2.39%/decade. In the primary visual cortex, putamen, and thalamus, the NFU values did not change significantly throughout the ages covered. These patterns were not significantly different between right and left cerebral hemispheres. Of interest was that the NFU in the left cerebellar cortex was increased with age after 20s at a rate of 2.86%/decade. Conclusion: These data demonstrate regional variation of the age-related changes in the cerebral glucose metabolism, with the most prominent age-related decline of metabolism in the prefrontal cortex. The increase in the cerebellar metabolism with age might reflect a process of neuronal plasticity associated with aging. (Korean J Nucl Med 2001;35:231-240)

의사결정트리 프로그램 개발 및 갑상선유두암에서 질량분석법을 이용한 단백질 패턴 분석

윤준기 ( Joon Kee Yoon ),이준 ( Jun Lee ),안영실 ( Young Sil An ),박복남 ( Bok Nam Park ),윤석남 ( Seok Nam Yoon ) 대한핵의학회 2007 핵의학 분자영상 Vol.41 No.4

유방암에서 18F-FDG PET의 임상 이용

윤준기 ( Joon Kee Yoon ) 대한핵의학회 2008 핵의학 분자영상 Vol.42 No.-

Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?

( Yoon Je Cho ),( Young Soo Chun ),( Kee Hyung Rhyu ),( Joon Soon Kang ),( Gwang Young Jung ),( Jun Hee Lee ) 대한고관절학회 2015 Hip and Pelvis Vol.27 No.4

Purpose: This study was designed to investigate the effect of bisphosphonate administration starting time on bone healing and to identify the best administration time following surgical treatment of osteoporotic intertrochanteric fractures. Materials and Methods: Two hundreds and eighty four patients (284 hips; 52 males, 232 females) who underwent surgery following osteoporotic intertrochanteric fracture from December 2002 to December 2012 were retrospectively analyzed. The average follow-up period was 68.4 months. The patients were divided into three groups according to the time of bisphosphonate administration after operation: 1 week (group A; n=102), 1 month (group B; n=89), and 3 months (group C; n=93). Koval scores and change of Koval scores 1 year after operation were used for clinical evaluation. For radiologic evaluation, the time of callus appearance across the fracture line on sagittal and coronal radiographs and the time to absence of pain during hip motion was judged as the time of bone union. Results: Koval scores one year after surgery for groups A, B, and C were 2.44, 2.36, and 2.43 (P=0.895), respectively. The mean time of union was 12.4, 11.9, and 12.3 weeks after operation in the three groups (P=0.883), respectively. There were zero cases of nonunion. There were 3, 5, and 7 cases of fixative displacement in the three groups, respectively, but the distribution showed no significant difference (P>0.472). Conclusion: The initiating time of bisphosphonate administration following surgery does not affect the clinical outcomes in patients with osteoporotic intertrochanteric fracture.