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Serotonin Inhibits Osteoblast Differentiation and Bone Regeneration in Rats
Nam, Soon-Shin,Lee, Jeong Cheol,Kim, Hyo Jeong,Park, Jin-Woo,Lee, Jae-Mok,Suh, Jo-Young,Um, Heung-Sik,Kim, Jae-Young,Lee, Youngkyun,Kim, Yong-Gun American Academy of Periodontology 2016 Journal of periodontology Vol.87 No.4
<P>Background: Although increasing evidence indicates that serotonin (SER; 5-hydroxytrypamine [5-HT]) is involved in the regulation of bone metabolism, conflicting data exist regarding whether SER promotes or inhibits osteoblast differentiation and bone formation. Regeneration of functional bone is required for proper osseointegration of dental implants. Noticeably, the use of selective SER reuptake inhibitors was recently associated with the failure of osseointegrated dental implants. The present study examines the direct role of peripheral SER on the regulation of bone regeneration. Methods: The effect of SER on osteoblast differentiation and bone regeneration was examined using rat calvarial cell cultures in vitro and a rat critical-sized calvarial defect model in vivo. Results: Rat calvarial cells expressed SER receptors Htr1 (5HT1) and Htr2 (5-HT2), which are known to transmit signals in bone cells. In vitro, SER significantly reduced osteogenic differentiation and mineralization of rat calvarial cells with concomitant reduction of osteoblast marker genes including alkaline phosphatase (Alpl), osterix (Sp7), and osteocalcin (Bglap). Histologic and radiologic analyses using the rat critical-sized calvarial defect model revealed that the existence of SER significantly inhibited beta-phase tricalcium phosphate-induced bone regeneration. Conclusion: Results suggest that SER in the local bone microenvironment might play a negative role in osteoblast differentiation and bone formation in rats.</P>
Comprehensive Analysis of Blood Culture Performed at Nine University Hospitals in Korea
Shin, Jeong Hwan,Song, Sae Am,Kim, Mi-Na,Lee, Nam Yong,Kim, Eui-Chong,Kim, Sunjoo,Koo, Sun-Hoi,Ryoo, Nam Hee,Kim, Jae-Seok,Cho, Ji-Hyun The Korean Society for Laboratory Medicine 2011 Annals of Laboratory Medicine Vol.31 No.2
<P><B>Background</B></P><P>Optimal blood culture performance is critical for successful diagnosis and treatment of sepsis. To understand the status of blood culture, we investigated several aspects of the procedure at 9 university hospitals.</P><P><B>Methods</B></P><P>The process of ordering blood culture sets and sampling volume for adults and children was investigated from January 2010 to April 2010, while the positive rate of detection and growth of skin contaminants were compared in 2009. Microbial growth in aerobic and anaerobic bottles was investigated prospectively.</P><P><B>Results</B></P><P>A majority of the hospitals used 2 sets of bottles for adults and 1 bottle for children. The average blood volume in each set was 7.7 mL for adults and 2.1 mL for children. The positive rate of microorganisms was 8.0%, and the isolation rate of the normal flora of the skin was 2.1%. Bacterial growth rates in aerobic and anaerobic bottles only were 31.8% and 24.5% respectively.</P><P><B>Conclusions</B></P><P>Ordering blood culture sets and sampling volumes did not comply with CLSI guidelines. However, the rate of positive cultures and skin contamination rates were acceptable. Anaerobic bottles are useful in enhancing the yield of microorganisms.</P>
A new mid-late maturing japonica rice variety Hyeonpum with a good grain quality and eating quality
Jeong-Ju Kim,Woon-Chul Shin,Mun-Sik Shin,Ki-Yeong Kim,Bo-Kyeong Kim,Jeong-Kwon Nam,Jong-Cheol Ko,Hyeon-Su Park,Ki-Yong Ha,Man-Kee Baek,So-Hyeon Baek,Young-Jun Mo,Woo-Jae Kim,Hyeon-Jung Kang,Jae-Kwon K 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
‘Hyeonpum’ is a new japonica rice variety developed by a cross breeding between Iksan469 having a good canopy architecture and Sindongjin and Musashino 7 having a good eating-quality with a view to develop a new variety having high quality of grain and palatability by the rice breeding team of Rice Breeding and Cultivation Research Division, Department of Rice and Winter Cereal Crop, NICS, RDA in 2012. The heading date of this variety is August 18 and later than that of check variety, Nampyeongbyeo, by four days. ‘Hyeonpum’ has 74cm of culm length and 101 spikelets per panicle. This variety showed resistance to bacterial leaf blight and rice stripe virus, but susceptible to leaf blast and planthoppers. The milled rice of this variety exhibits translucent and very clear non-glutinous endosperm. ‘Hyeonpum’ has much better palatability of cooked rice than that of Nampyeongbyeo. The whole grain rate of milled rice and milled rice recovery of ‘Hyeonpum’ are slightly higher than those of Nampyeongbyeo as 91.8% and 75.2% respectively. The yield of ‘Hyeonpum’ is 5.6 MT/ha in milled rice. ‘Hyeonpum’ could be adaptable to the southern part plain area of Pyeongtaek and southwestern costal areas in Korea.
남부평야지 조기재배 적응 복합내병성 고품질 조생 벼 ‘조일’
남정권(Jeong Kwon Nam),박현수(Hyun Su Park),김기영(Ki Young Kim),김보경(Bo Kyeong Kim),조영찬(Young Chan Cho),고재권(Jae Kwon Ko),백만기(Man Kee Baek),김정주(Jeong Ju Kim),김우재(Woo Jae Kim),신운철(Woon Chul Shin),고종철(Jong Cheol 한국육종학회 2018 한국육종학회지 Vol.50 No.3
‘Joil’ is a multiple disease resistant early maturing rice cultivar with high grain quality. ‘Joil’ was derived from a single cross between ‘Unbong37’ (cultivar name ‘Unmi’) and ‘HR23156-26-2-3-5’. ‘Unmi’ is an early maturing rice cultivar with high grain quality and resistance to rice blast and stripe virus. ‘HR23156-26-2-3-5’ is an early maturing elite rice line with lodging resistance and cold tolerance. ‘Joil’ was selected through the pedigree method, yield trials, and local adaptability tests. ‘Joil’ was an early maturing rice. The heading date of ‘Joil’ was July 16 in early transplanting cultivation, which was 2 days later than that of ‘Jopyeong’. ‘Joil’ was a lodging resistance rice with a short culm and showed better tolerance to viviparous germination than that of ‘Jopyeong’. ‘Joil’ was a multiple disease resistant rice with resistance against rice blast, bacterial blight, and stripe virus. ‘Joil’ showed higher yield in both early and late-transplanting cultivations than those of the standard rice cultivars ‘Jopyeong’ and ‘Geumo’. ‘Joil’ had enhanced grain quality under high temperature ripening conditions in early transplanting cultivation. The cooked rice had good grain appearance and taste attributes, and this cultivar had a higher head rice ratio than that of ‘Jopyeong’. ‘Joil’, a multiple disease resistant early maturing rice cultivar with high grain quality, would be suitable for early transplanting cultivation in the southern plain area (Registration No. 6792).
남정희 ( Nam Jeong-hee ),조인철 ( Cho In-chol ),최명신 ( Choi Myung-shin ),김영수 ( Kim Young-su ),조삼재 ( Cho Sam-jai ),신성우 ( Shin Sung-woo ) 한국구조물진단유지관리공학회 1998 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.2 No.1
The purpose of this study is to evaluate shear strengthening effects of R/C beams with carbon fiber sheets. The major variables are shear reinforcement ratios, CFS strengthening ratios and strengthening methods of CFS. Following conclusions can be extracted. The shear capacity of beam strengthened with CFS is about 32 ~87% higher than that of beams without shear reinforcement. The strengthening effects of patch type is larger than those of strip type. The strain distribution in CFS intersected with shear crack is similar to that in stirrup and larger strain is observed in the middle of the shear span. The different effects of strengthening methods were not found. It can be estimated that shear strength reduction factor a =0.6 is appropriate for peeling effect of CFS
Kwon, Jeong Hyun,Park, Junhong,Lee, Myung Keun,Park, Jeong Woo,Jeon, Yongmin,Shin, Jeong Bin,Nam, Minwoo,Kim, Choong-Ki,Choi, Yang-Kyu,Choi, Kyung Cheol American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.18
<P>The lack of reliable, transparent, and flexible electrodes and insulators for applications in thin-film transistors (TFTs) makes it difficult to commercialize transparent, flexible TFTs (TF-TFTs). More specifically, conventional high process temperatures and the brittleness of these elements have been hurdles in developing flexible substrates vulnerable to heat. Here, we propose electrode and insulator fabrication techniques considering process temperature, transmittance, flexibility, and environmental stability. A transparent and flexible indium tin oxide (ITO)/Ag/ITO (IAI) electrode and an Al<SUB>2</SUB>O<SUB>3</SUB>/MgO (AM)-laminated insulator were optimized at the low temperature of 70 °C for the fabrication of TF-TFTs on a polyethylene terephthalate (PET) substrate. The optimized IAI electrode with a sheet resistance of 7 Ω/sq exhibited the luminous transmittance of 85.17% and maintained its electrical conductivity after exposure to damp heat conditions because of an environmentally stable ITO capping layer. In addition, the electrical conductivity of IAI was maintained after 10 000 bending cycles with a tensile strain of 3% because of the ductile Ag film. In the metal/insulator/metal structure, the insulating and mechanical properties of the optimized AM-laminated film deposited at 70 °C were significantly improved because of the highly dense nanolaminate system, compared to those of the Al<SUB>2</SUB>O<SUB>3</SUB> film deposited at 70 °C. In addition, the amorphous indium-gallium-zinc oxide (a-IGZO) was used as the active channel for TF-TFTs because of its excellent chemical stability. In the environmental stability test, the ITO, a-IGZO, and AM-laminated films showed the excellent environmental stability. Therefore, our IGZO-based TFT with IAI electrodes and the 70 °C AM-laminated insulator was fabricated to evaluate robustness, transparency, flexibility, and process temperature, resulting in transfer characteristics comparable to those of an IGZO-based TFT with a 150 °C Al<SUB>2</SUB>O<SUB>3</SUB> insulator.</P> [FIG OMISSION]</BR>