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RISS 인기검색어
- 검색키워드
- 저자 : Jean Louis Lefebvre (검색결과 3 건)
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Surgery for Laryngopharyngeal SCC in the Era of Organ Preservation
Jean Louis Lefebvre 대한이비인후과학회 2009 Clinical and Experimental Otorhinolaryngology Vol.2 No.4
Over the past decades, randomized clinical trials have assessed and validated the concept of larynx preservation. This new concept has obviously modified the treatment algorithm for laryngopharyngeal squamous cell carcinoma. However surgery for larynx and hypopharynx cancer remains indicated in many cases. Initial partial surgery is indicated for early diseases. This surgery may be performed endoscopically or openly. The results are excellent in terms of local control and function. Transoral robotic surgery is under evaluation. Initial radical surgery is indicated for advanced diseases in case of very infiltrative tumor, in case of cartilage destruction or when tolerance and/or compliance to chemotherapy-based approached is questionable. Larynx preservation is to be discussed between these two situations. In randomized trials evaluating the different larynx preservation strategies, a substantial number of larynxes could be preserved without compromising disease control or survival. The best approach in terms of quality of function preservation, overall acute and late toxicity, disease control and survival is still a matter of clinical research. It must be stressed that salvage surgery is a definite part of these larynx preservation protocols in order to maintain the ultimate disease control. This discussion underscored the need of a multidisciplinary decision making and the need of a coordinated clinical research. Over the past decades, randomized clinical trials have assessed and validated the concept of larynx preservation. This new concept has obviously modified the treatment algorithm for laryngopharyngeal squamous cell carcinoma. However surgery for larynx and hypopharynx cancer remains indicated in many cases. Initial partial surgery is indicated for early diseases. This surgery may be performed endoscopically or openly. The results are excellent in terms of local control and function. Transoral robotic surgery is under evaluation. Initial radical surgery is indicated for advanced diseases in case of very infiltrative tumor, in case of cartilage destruction or when tolerance and/or compliance to chemotherapy-based approached is questionable. Larynx preservation is to be discussed between these two situations. In randomized trials evaluating the different larynx preservation strategies, a substantial number of larynxes could be preserved without compromising disease control or survival. The best approach in terms of quality of function preservation, overall acute and late toxicity, disease control and survival is still a matter of clinical research. It must be stressed that salvage surgery is a definite part of these larynx preservation protocols in order to maintain the ultimate disease control. This discussion underscored the need of a multidisciplinary decision making and the need of a coordinated clinical research.
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Hasina Santatriniaina Rasolomboahanginjatovo,Younès Chorfi,Raynald Dupras,Louis Mills,Réjean Lefebvre 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2
The objective of this study was to determine the effects ofsuperovulation (SOV) on serum and uterine biochemicalparameters, uterine bacteriology and cytology and number oftransferable embryos (TE). Dairy cows were placed on aPresynch/CIDR Synch protocol. The SOV group wassuperovulated, induced in estrus, and inseminated, whereasthe control group was induced in estrus and inseminatedwithout SOV. Uterine bacteriology and cytology and uterineand serum biochemical parameters were measured at day 7of the estrous cycle to start the SOV protocol, as well as on theday of embryo recovery (DER). The SOV group produced 7.5± 6.7 oocytes/embryos, of which 3.4 ± 4.7 were TE. Serumurea and E2 and uterine Glu, CK, LDH, TP, P4 and PGFM inthe control group and serum P4 and PGFM and uterine LDHand PGFM in the SOV group were significantly higher (p <0.01) at DER than day 7. At DER, uterine urea, LDH, PGFMand TP and serum urea, LDH, PGFM, and P4 concentrationswere higher (p < 0.01) in the SOV group than the control. There was no significant variation in uterine bacteriology orcytology. Overall, these results infer that SOV affects bothserum profile and uterine secretions, and that these changesmay influence the number of TE.
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Valérie Chetboul,Cécile Damoiseaux,Hervé P. Lefebvre,Didier Concordet,Loic Desquilbet,Vassiliki Gouni,Camille Poissonnier,Jean-Louis Pouchelon,Renaud Tissier 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.5
Our aim was (1) to determine the within-day and between-day variability of several indices of systolic and diastolic right ventricular (RV) function by using conventional echocardiography and speckle-tracking echocardiography (STE) (Study 1), (2) to quantify these variables in a large healthy canine population (n = 104) with Doppler-derived estimated systolic pulmonary arterial pressure (SPAP) and left ventricular (LV) function, and (3) to establish the corresponding reference intervals (Study 2). For both studies, RV variables included tricuspid annular plane systolic excursion (TAPSE), right fractional area change (RFAC), STE longitudinal systolic strain (StS) of the RV free wall (RVFW) and of the entire RV (i.e., global RV StS), STE longitudinal systolic RVFW strain rate (SRS), and the diastolic early:late strain rate ratio. All but one within- and between-day coefficients of variation (13/14) were < 15%, the lowest being observed for TAPSE (3.6–9.8%), global RV StS (3.8–9.9%), and RVFW StS (3.7–7.3%). SPAP was weakly and negatively correlated with the TAPSE:body weight ratio (rs = –0.26, p = 0.01) and RVFW SRS (rs = –0.23, p < 0.05). Reference intervals (lower and upper limits with 90% confidence intervals) were provided for all variables. STE provides a non-invasive evaluation of RV function that may be used for clinical investigations in canine cardiology.
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