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Vivi Koffi,Jean Lorrain KINFORMS 2010 Management Review Vol.5 No.2
The problematic issue of successor‘s acceptance in a family business has not yet reached researchers‘ attention. This comparative case study put the emphasis on how men/women predecessors will bring their business people toward successors‘ acceptance. The results reveal that, when predecessors put their confidence into themselves, they will adopt, in turn, different behavioral strategies than their own. In doing so, the successor‘s acceptance process by company personnel differs depending on the predecessor‘s gender. This study shows the importance to take into account the predecessor‘s gender in future studies on family succession of small and medium sized enterprises (SMEs).
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Conventional Dendritic Cells Impair Recovery after Myocardial Infarction
Lee, Jun Seong,Jeong, Se-Jin,Kim, Sinai,Chalifour, Lorraine,Yun, Tae Jin,Miah, Mohammad Alam,Li, Bin,Majdoubi, Abdelilah,Sabourin, Antoine,Keler, Tibor,Guimond, Jean V.,Haddad, Elie,Choi, Eui-Young,Ep American Association of Immunologists 2018 Journal of Immunology Vol. No.
<P>Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103<SUP>+</SUP> conventional dendritic cell (cDC)1s, CD11b<SUP>+</SUP> cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34<SUP>+</SUP> cells, respectively. After myocardial infarction (MI), the specific depletion of cDCs, but not pDCs, improved cardiac function and prevented adverse cardiac remodeling. Our results showed that fractional shortening measured after MI was not influenced by the absence of pDCs. Interestingly, however, depletion of cDCs significantly improved reduction in fractional shortening. Moreover, fibrosis and cell areas were reduced in infarcted zones. This correlated with reduced numbers of cardiac macrophages, neutrophils, and T cells, indicating a blunted inflammatory response. Accordingly, mRNA levels of proinflammatory cytokines IL-1β and IFN-γ were reduced. Collectively, our results demonstrate the unequivocal pathological role of cDCs following MI.</P>
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