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Onur Çağlar Acar,Abdurrahman Üner,Mehmet Fatih Garça,İbrahim Ece,Serdar Epçaçan,Mahfuz Turan,Ferhat Kalkan 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.2
Objectives. The purpose of the present study is to emphasize the efficacy of the myocardial performance index and tricuspid annular plane systolic excursion (TAPSE) in the determination of impaired cardiac functions and recovery period following the treatment in children with adenoid and/or tonsillar hypertrophy. Methods. Fifty-three healthy children after routine laboratory, imaging and clinical examinations, with adenoid and/or tonsillar hypertrophy were evaluated before and 3 months after adenotonsillectomy for cardiac functions using M mode and Doppler echocardiography. Results. The mean age of cases was 6.4±3.0 years, 34 (65%) were male, and 19 (35%) were female. Pulmonary hypertension was observed to be mild in 3 patients and moderate in 1 patient preoperatively. When the preoperative and postoperative echocardiographic measurements of the patients were compared, the tricuspid valve E wave velocity, the E/A ratio (E, early diastolic flow rate; A, late diastolic flow rate), and the TAPSE values were determined to be significantly higher postoperatively (P<0.05). The tricuspid valve deceleration time, the isovolumetric relaxation time and the systolic pulmonary artery pressure were found to be significantly lower compared to the preoperative values (P<0.05). Conclusion. Adenoidectomy and/or tonsillectomy may prevent cardiac dysfunctions that can develop in the later periods due to adenoid and/or tonsil hypertrophy in children, before the appearance of the clinical findings of cardiac failure.
Mundhofir, Farmaditya EP,Wulandari, Catharina Endah,Prajoko, Yan Wisnu,Winarni, Tri Indah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Specific patterns of the hereditary breast and ovarian cancer (HBOC) syndrome are related to mutations in the BRCA1 gene. One hundred unrelated breast cancer patients were interviewed to obtain clinical symptoms and signs, pedigree and familial history of HBOC syndrome related cancer. Subsequently, data were calculated using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk prediction model. Patients with high score of BOADICEA were offered genetic testing. Eleven patients with high score of BOADICEA, 2 patients with low score of BOADICEA, 2 patient's family members and 15 controls underwent BRCA1 genetic testing. Mutation screening using PCR-HRM was carried out in 22 exons (41 amplicons) of BRCA1 gene. Sanger sequencing was subjected in all samples with aberrant graph. This study identified 10 variants in the BRCA1 gene, consisting of 6 missense mutations (c.1480C>A, c.2612C>T, c.2566T>C, c.3113A>G, c.3548 A>G, c.4837 A>G), 3 synonymous mutations (c.2082 C>T, c.2311 T>C and c.4308T>C) and one intronic mutation (c.134+35 G>T). All variants tend to be polymorphisms and unclassified variants. However, no known pathogenic mutations were found.
Jeong Hyun Lee(이정현),Ep Heuvelink,Menno J. Bakker 한국원예학회 2009 원예과학기술지 Vol.27 No.3
광수준에 따른 재식밀도가 연중 스프레이 절화국의 생육패턴과 품질에 미치는 상호작용 효과를 구명 하고, 기존의 경험적인 국화 생장 및 품질 예측 모델의 검증을 하고자 본 연구를 수행하였다. 절화국(Chrysanthemum morifolium) ‘Reagan Improved’를 재식밀도 16, 32, 64와 80 plants m?² 와 광수준 100%, 66%와 43%를 조합하여 여름철에 네덜란드에 있는 독립된 유리온실3개 구역에서 실험을 수행하였다. 식물의 생체중과 건물중, 화수와 줄기의 강도 및 초장은 광수준과 재식밀도간의 상호작용 효과가 유의하였으며, 생육량과 줄기의 품질은 광수준이 증가하고 식물체당 차지하는 면적 증가할수록 그 차이가 컸고, 광수준이 낮아 질수록 재식밀도간의 생육특성의 차이가 작았다. 재식밀도가 높은 64-80 plant m?²에서는 초장의 차이가 나타나지 않았지만, 광수준 43%에서는 초장인 64 plants m?²까지 증가하다가 80 plants m?²에서 감소하는 quadratic 반응을 나타내었다. 단위면적당 건물생산량과 엽면적지수는 광수순과 재식밀도에 따라 증가하였고, 광이용효율(LUE)은 가장 낮은 광수준에서 가장 높게 나타났으며, 재식밀도 16-80 plants/m2 범위에서는 quadratic 반응을 보였다. 절화의 외형적인 품질인 초장 대비 스프레이길이 비율(초장대비 첫 개화지 마디부터 생상점까지의 길이의 비)은 엽면적 지수와 부의 상관을 나타내었다. 경험적 모델식 들은 낮은 재식밀도 범위에서 생체중과 꽃의 개수를 과대평가되었다. 경험적인 단순모델은 연구결과를 요약할 수 있는 도구로 사용할 수 있을 것으로 사료된다. 연중 균일한 품질(줄기당 개화수 및 줄기강도, 개체당 줄기의 형태 등)은 광량과 재식밀도간의 상호작용효과가 매우 높기 때문에 스케줄에 의한 재식밀도의 결정보다는 외부광량에 따른 적정 재식밀도를 고려가 매우 중요할 것으로 생각된다. Aims of this study are to analyze growth pattern and development of cut chrysanthemum and test simple regression models in relation to light level and plant density. Cut chrysanthemum (Chrysanthemum morifolium), cv. Reagan Improved, was grown at four different plant densities of 16, 32, 64 or 80 plants m?² combined with three different light levels of 100%, 66% or 43% of light in three greenhouse compartments in summer at Wageningen University in the Netherlands. Plant fresh and dry mass, stem strength, number of flowers and stem length had shown interactive effects between light level and plant density. All these parameters increased with increased light level and with increased plant density; however, the decrease as a result of light reduction was much larger at low plant densities except for stem length. Stem length increased with increased plant density, following a saturation-type of response, except for the lowest light level, where an optimum-response was observed, resulting in a reduced stem length at the highest density. Dry mass production per m2 greenhouse area and final leaf area index increased with increased light level and with increased plant density. Light use efficiency (LUE, unit dry mass per unit of cumulative intercepted PAR) was 48% higher at lower light levels than 100%. LUE also showed a quadratic response to plant density in range of 16 and 80 plant m?². Using an existing empirical linear model for plant, fresh mass and number of flowers for cut chrysanthemum showed overestimation in plant fresh mass and under estimation for number of flowers at the lowest plant density in all light level in this study. Plant shape, calculated as a ratio between stem length and a length between a node with first lateral stem to top point of plant, linearly decreased with increased LAI. Plant qualities hence strongly varied depending on crop canopy like leaf area index. Although the simple regression models are good tools for summary of experiment, it does not fit at lower plant density. To produce a constant product quality throughout the year, optimal number of plant m?² with amount of available light should be considered through the growing period.