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Hydraulic Runner Design Method for Lifetime
Sabourin, Michel,Thibault, Denis,Bouffard, David-Alexandre,Levesque, Martin Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.4
Quest for reliability of hydraulic runners is a concern for all mature electricity producers. The fatigue damage caused by dynamics loads is frequently the root cause of runner failure. This paper presents the damage tolerance approach based on fracture mechanics as the method chosen by Alstom and Hydro-Qu$\acute{e}$bec to predict effects of damage on runner lifetime and consequently to be use as a design method. This is sustained by a research on fracture mechanics properties of runner materials and by recommendations on the strategy to define a safety margin for design. The acquired knowledge permits to identify potential improvement of the runner lifetime without significant cost increase, like being more specific on some chemical composition or heat treatment.
ITER vacuum vessel structural analysis completion during manufacturing phase
Martinez, J.M.,Alekseev, A.,Sborchia, C.,Choi, C.H.,Utin, Y.,Jun, C.H.,Terasawa, A.,Popova, E.,Xiang, B.,Sannazaro, G.,Lee, A.,Martin, A.,Teissier, P.,Sabourin, F.,Caixas, J.,Fernandez, E.,Zarzalejos, North-Holland 2016 Fusion engineering and design Vol.109 No.1
Some years ago, analyses were performed by ITER Organization Central Team (IO-CT) to verify the structural integrity of the ITER vacuum vessel baseline design fixed in 2010 and classified as a Protection Important Component (PIC). The manufacturing phase leads the ITER Organization domestic agencies (IO-DA) and their contracted manufacturers to propose detailed design improvements to optimize the manufacturing or inspection process. These design and quality inspection changes can affect the structural margins with regards to the Codes&Standards and thus oblige to evaluate one more time the modified areas. This paper proposes an overview of the additional analyses already performed to guarantee the structural integrity of the manufacturing designs. In this way, CT and DAs have been strongly involved to keep the considerable margins obtained previously which were used to fix reasonable compensatory measures for the lack of In Service Inspections of a Nuclear Pressure Equipment (NPE).
Conventional Dendritic Cells Impair Recovery after Myocardial Infarction
Lee, Jun Seong,Jeong, Se-Jin,Kim, Sinai,Chalifour, Lorraine,Yun, Tae Jin,Miah, Mohammad Alam,Li, Bin,Majdoubi, Abdelilah,Sabourin, Antoine,Keler, Tibor,Guimond, Jean V.,Haddad, Elie,Choi, Eui-Young,Ep American Association of Immunologists 2018 Journal of Immunology Vol. No.
<P>Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103<SUP>+</SUP> conventional dendritic cell (cDC)1s, CD11b<SUP>+</SUP> cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34<SUP>+</SUP> cells, respectively. After myocardial infarction (MI), the specific depletion of cDCs, but not pDCs, improved cardiac function and prevented adverse cardiac remodeling. Our results showed that fractional shortening measured after MI was not influenced by the absence of pDCs. Interestingly, however, depletion of cDCs significantly improved reduction in fractional shortening. Moreover, fibrosis and cell areas were reduced in infarcted zones. This correlated with reduced numbers of cardiac macrophages, neutrophils, and T cells, indicating a blunted inflammatory response. Accordingly, mRNA levels of proinflammatory cytokines IL-1β and IFN-γ were reduced. Collectively, our results demonstrate the unequivocal pathological role of cDCs following MI.</P>