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Salmonella typhimurium에 의한 고관절염 1예
구명숙,최신은,조웅제,김근우,김의종,지제근 대한감염학회 1992 감염 Vol.24 No.4
Salmonella septic arthritis is unusual and rare manifestation noted in fewer than 1% of salmonellosis. S. typhimurium is the most prevalent among the salmonella species from clinical specimens including bone and joint in United States and other countries, on the other hand, S. typhi is the most frequent organism in Korea. There has been no case report of septic arthritis caused by S. typhimurium in Korea. We report the first case of septic arthritis due to S. typhimurium in a patient with diabetes mellitus. The patient was a 43-year-old male. He had undergone sequestrectomy and iliac bone graft of the hip joint because of tuberculosis 16 years age, thereafter he took oral anti-tuberculous medication for a year. Six months before admission high fever and copious pus discharge were noted. And he was admitted to the our hospital via local clinic in Cheju Island, where new onset of diabetes mellitus was detected, for further proper managements. There was no history of Salmonella septicemia, dysenteric infection or pulmonary tuberculosis. Physical examination revealed warm, swollen and tender areas with two active draining sinuses on the anterolateral aspect of right hip joint, which was in fused state. And there were also an old operation scar and five healded draining sinuses. Cultures of pus obtained from right hip at reoperation grew group B Salomonella which was positive for H₂S, motility, citrate, fermentation of mannitol and sorbitol. Salmonella was finally identified as S. typhimurium having 1, 4, 5 and 12 of somatic (O) antigen, i on phase 1, 1 and 2 on phase 2 of flagella (H) antigens by Serological tests performing at National Institute of Health. In the other laboratory findings were as follows; WBC 12,000/㎕, Hb/Hct 15.2/46, platelets 510,000/㎕ on CBC, FBS/pp2h:330/482, glucosuria (3+), CRP(3+), Cryglobulin(-), anti-HIV Ab(-), 1:40 in both O and H titer of Widal tests, and HLA B27(-). AFB was not isolated on stained smears and cultures. He was treated with cefradine 1.0g and kanamycin 1.0g initially and chloramphenicol 1.0g daily for 6 weeks. And 8 U RI and 16 U human insulin(Novolyn N) were administrated for DM control. He responded to the treatment and he was retransferred to Cheju local clinic for continuous DM control.
지제근 대한신경외과학회 1984 Journal of Korean neurosurgical society Vol.13 No.4
이상 선하수체 선종에 대한 몇가지 형태학적 기술을 하였거니와 근래에 와서 발달된 면연조직화학과 전자 현밍경의 이용으로 그동안 괴리상태에 있던 하수체종양의 형태와 기능의 상관관계가 대폭적으로 근접하였다고 할수 있다. 그러나 null cell tumor 를 비롯한 mi-xed cell adenoma 등 아직 해결되지 않은 문제들이 남아 있다. 이러한 문제도 새로운 분석 방법의 도입과 더불어 발전되는 내분비학의 방법론에 힘입어 가까운 장래에 해결되리라라고 믿는다
池堤根,崔信恩,李濟九 서울대학교 1967 서울대학교 論文集 Vol.18 No.-
Pathoanatomical and histopathological studies were made on seven autopsy cases of congenital syphilis which were bacteriologically or serologically confirmed. Seven cases of congenital syphilis were all new born infants that expired within a month. Clinically, dyspnea and skin rashes were the most pronounced findings. Hepatosplenomegaly was marked. Blood examination showed severe anemia in all. Grossly, heart, liver, spleen and lungs were generally increased in weight. They were uniformly firm and revealed grayish hue. Microscopical findings were principally composed of diffuse visceral fibrosis, inflammatory cell infiltration and widespread extramedullary hematopoisis. Visceral fibrosis was most marked in the pancreas, lung and liver, although spleen, kidneys, thymus and adrenals were also involved. Pertinent autopsy findings are as follows: Skin shows maculo-papular lesion. Heart shows endocardial fibrosis in one case and the others show capillary congestion with endothelial swelling. Lungs are enlarged and uniformly firm. Alveolar septa show diffuse fibrosis and cell infiltration showing the picture of so called "pneumonia alba". Liver section is characterized by extensive periportal fibrosis and diffuse hematopoiesis. These fibrotic changes are more marked in right lobe especially along ductus venosus. Giant cells are frequently observed and this picture was discussed along the line of giant cell transformation of hepatic cells. Spleen is enlarged and shows diffuse increase of fibrous connective tissue in addition to extramedullary hemopoisis. Pancreas shows rather extensive fibrosis together with acinar atrophy and inflammatory cellular aggregates. Langerhans islets appear to be enlarge in some cases. Adrenal glands shows fibrosis in cortex together with capsular fibrosis. However, inflammatory cell infiltration is rather meager. Adrenal cytomegalia which is
지제근 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.1
뇌내출혈(intracerebral hemorrhage)은 넓은 의미로 쓰이는 뇌출(cerevral hemorrhage)인 두개내 출혈(intracranial hemorrhage)중 그 출혈부가 뇌의 실질내에 위치하고 있는 것을 말한다. 뇌내출혈은 따라서 두개강내 출혈중 뇌외출혈(extracerebral hemorrhage)인 경뇌막의 출혈, 경뇌막하 출혈 및 지주막하 출혈등이 제외된 것을 의미 한다고 생각된다.