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RISS 인기검색어
- 검색키워드
- 저자 : Jamal Ansari (검색결과 3 건)
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Jamal, Qazi Mohammad Sajid,Dhasmana, Anupam,Lohani, Mohtashim,Firdaus, Sumbul,Ansari, Md Yousuf,Sahoo, Ganesh Chandra,Haque, Shafiul Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13
Cigarette smoke derivatives like NNK (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone) and NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol) are well-known carcinogens. We analyzed the interaction of enzymes involved in the NER (nucleotide excision repair) pathway with ligands (NNK and NNAL). Binding was characterized for the enzymes sharing equivalent or better interaction as compared to +Ve control. The highest obtained docking energy between NNK and enzymes RAD23A, CCNH, CDK7, and CETN2 were -7.13 kcal/mol, -7.27 kcal/mol, -8.05 kcal/mol and -7.58 kcal/mol respectively. Similarly the highest obtained docking energy between NNAL and enzymes RAD23A, CCNH, CDK7, and CETN2 were -7.46 kcal/mol, -7.94 kcal/mol, -7.83 kcal/mol and -7.67 kcal/mol respectively. In order to find out the effect of NNK and NNAL on enzymes involved in the NER pathway applying protein-protein interaction and protein-complex (i.e. enzymes docked with NNK/NNAL) interaction analysis. It was found that carcinogens are well capable to reduce the normal functioning of genes like RAD23A (HR23A), CCNH, CDK7 and CETN2. In silico analysis indicated loss of functions of these genes and their corresponding enzymes, which possibly might be a cause for alteration of DNA repair pathways leading to damage buildup and finally contributing to cancer formation.
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( Rajeev Kumar ),( Md Tarique Jamal Ansari ),( Abdullah Baz ),( Hosam Alhakami ),( Alka Agrawal ),( Raees Ahmad Khan ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.1
One of the biggest challenges that the software industry is facing today is to create highly efficient applications without affecting the quality of healthcare system software. The demand for the provision of software with high quality protection has seen a rapid increase in the software business market. Moreover, it is worthless to offer extremely user-friendly software applications with no ideal security. Therefore a need to find optimal solutions and bridge the difference between accessibility and protection by offering accessible software services for defense has become an imminent prerequisite. Several research endeavours on usable security assessments have been performed to fill the gap between functionality and security. In this context, several Multi-Criteria Decision Making (MCDM) approaches have been implemented on different usability and security attributes so as to assess the usable-security of software systems. However, only a few specific studies are based on using the integrated approach of fuzzy Analytic Network Process (FANP) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) technique for assessing the significant usable-security of hospital management software. Therefore, in this research study, the authors have employed an integrated methodology of fuzzy logic, ANP and TOPSIS to estimate the usable - security of Hospital Management System Software. For the intended objective, the study has taken into account 5 usable-security factors at first tier and 16 sub-factors at second tier with 6 hospital management system softwares as alternative solutions. To measure the weights of parameters and their relation with each other, Fuzzy ANP is implemented. Thereafter, Fuzzy TOPSIS methodology was employed and the rating of alternatives was calculated on the foundation of the proximity to the positive ideal solution.
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Alok Das,Manoj Kumar,Arvind Kumar Singh,Alok Shukla,Jamal Ansari,Subhojit Datta,Narendra Pratap Singh 한국작물학회 2016 Journal of crop science and biotechnology Vol.19 No.4
Production of transgenic pigeonpea is becoming increasingly important, but the methods currently employed in production and subsequent screening still requires improvement. Here, we describe Agrobacterium-mediated genetic transformation of pigeonpea with reporter uidA (gus) gene and selectable marker, neomycin phospho-transferase (nptII) gene. Histochemical assay demonstrate localization of gus activity in cells and transformed plants. Overall, a transformation frequency of 0.33% was achieved using the protocol. Grafting of in vitro-regenerated healthy shoots indicates higher survival percent (72.6%), when stock and scion are of the same variety. Seeds harvested from primary transgenic plants can be screened based on lateral root inhibition strategy. Approximately 87% of the screened T1 plants were found to be PCR positive. In conclusion, in vitro grafting of transgenic pigeonpea shoots leads to better plant establishment and screening based on lateral root inhibition leads to quick identification of positive segregants.
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