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      • KCI등재

        Comparison of three different surface plank exercises on core muscle activity

        Lee, Jin,Jeong, Kwanghyun,Lee, Hyuna,Shin, Jaeyeon,Choi, Jaelim,Kang, Seungbeom,Lee, Byoung-Hee korean Academy of Physical Therapy Rehabilitation 2016 Physical therapy rehabilitation science Vol.5 No.1

        Objective: This study compared the muscle activities of the erector spinae (ES), the external oblique (EO), and the rectus abdominis (RA) on three different surfaces. The purpose of this study was to determine which surface induces the highest muscle activity during the plank exercises. The information from this study can be used to recommend plank exercises to athletes and patients with weak core muscles. Design: Cross-sectional study. Methods: The subjects include 20 adult males attending S University in Seoul. Participants completed each plank exercise on three different surfaces. To measure muscle activities, researchers used the values from electromyography. The measurement excluded the initial two and final two seconds and collected information on the RA, EO, and ES in each posture of each subject. Results: The left external oblique showed significant differences between the plank position on stable ground (ST) and the plank position using a suspension device (SL) (p<0.05) and between the plank position on the unstable ground (US) and SL (p<0.05). The right rectus abdominis and left rectus abdominis displayed statistically significant differences between the ST and the US (p<0.05) and between the ST and the SL (p<0.05). The right erector spinae had a statistically significant difference between ST and US (p<0.05). Conclusions: The plank exercise strengthens the core muscles effectively, and muscle activity is related to the posture of the exercise and the location of the muscle. These results suggest that plank exercises improve muscle activities. Additionally, plank exercises can be applied to general medical care.

      • A Nucleic-Acid Hydrolyzing Single Chain Antibody Confers Resistance to DNA Virus Infection in HeLa Cells and C57BL/6 Mice

        Lee, Gunsup,Yu, Jaelim,Cho, Seungchan,Byun, Sung-June,Kim, Dae Hyun,Lee, Taek-Kyun,Kwon, Myung-Hee,Lee, Sukchan Public Library of Science 2014 PLoS pathogens Vol.10 No.6

        <▼1><P>Viral protein neutralizing antibodies have been developed but they are limited only to the targeted virus and are often susceptible to antigenic drift. Here, we present an alternative strategy for creating virus-resistant cells and animals by ectopic expression of a nucleic acid hydrolyzing catalytic 3D8 single chain variable fragment (scFv), which has both DNase and RNase activities. HeLa cells (SCH7072) expressing 3D8 scFv acquired significant resistance to DNA viruses. Virus challenging with Herpes simplex virus (HSV) in 3D8 scFv transgenic cells and fluorescence resonance energy transfer (FRET) assay based on direct DNA cleavage analysis revealed that the induced resistance in HeLa cells was acquired by the nucleic acid hydrolyzing catalytic activity of 3D8 scFv. In addition, pseudorabies virus (PRV) infection in WT C57BL/6 mice was lethal, whereas transgenic mice (STG90) that expressed high levels of 3D8 scFv mRNA in liver, muscle, and brain showed a 56% survival rate 5 days after PRV intramuscular infection. The antiviral effects against DNA viruses conferred by 3D8 scFv expression in HeLa cells as well as an <I>in vivo</I> mouse system can be attributed to the nuclease activity that inhibits viral genome DNA replication in the nucleus and/or viral mRNA translation in the cytoplasm. Our results demonstrate that the nucleic-acid hydrolyzing activity of 3D8 scFv confers viral resistance to DNA viruses <I>in vitro</I> in HeLa cells and in an <I>in vivo</I> mouse system.</P></▼1><▼2><P><B>Author Summary</B></P><P>Most strategies for developing virus-resistant transgenic cells and animals are based on the concept of virus-derived resistance, in which dysfunctional virus-derived products are expressed to interfere with the pathogenic process of the virus in transgenic cells or animals. However, these viral protein targeting approaches are limited because they only target specific viruses and are susceptible to viral mutations. We describe a novel strategy that targets the viral genome itself, rather than viral gene products, to generate virus-resistant transgenic cells and animals. We functionally expressed 3D8 scFv which has both DNase and RNase activities, in HeLa cells and transgenic mice. We found that the transgenic cells and mice acquired complete resistance to two DNA viruses (HSV and PRV) without accumulating the virus, and showed delayed onset of disease symptoms. The antiviral effects against DNA viruses demonstrated in this study were caused by (1) DNase activity of 3D8 scFv in the nucleus, which inhibited DNA replication or RNA transcription and (2) 3D8 scFv RNase activity in the cytoplasm, which blocked protein translation. This strategy may facilitate control of a broad spectrum of viruses, including viruses uncharacterized at the molecular level, regardless of their genome type or variations in gene products.</P></▼2>

      • KCI등재후보

        Comparison of three different surface plank exercises on core muscle activity

        ( Jin Lee ),( Kwanghyun Jeong ),( Hyuna Lee ),( Jaeyeon Shin ),( Jaelim Choi ),( Seungbeom Kang ),( Byoung Hee Lee ) 물리치료재활과학회 2016 Physical therapy rehabilitation science Vol.5 No.1

        Objective: This study compared the muscle activities of the erector spinae (ES), the external oblique (EO), and the rectus abdominis (RA) on three different surfaces. The purpose of this study was to determine which surface induces the highest muscle activity during the plank exercises. The information from this study can be used to recommend plank exercises to athletes and patients with weak core muscles. Design: Cross-sectional study. Methods: The subjects include 20 adult males attending S University in Seoul. Participants completed each plank exercise on three different surfaces. To measure muscle activities, researchers used the values from electromyography. The measurement excluded the initial two and final two seconds and collected information on the RA, EO, and ES in each posture of each subject. Results: The left external oblique showed significant differences between the plank position on stable ground (ST) and the plank position using a suspension device (SL) (p<0.05) and between the plank position on the unstable ground (US) and SL (p<0.05). The right rectus abdominis and left rectus abdominis displayed statistically significant differences between the ST and the US (p<0.05) and between the ST and the SL (p<0.05). The right erector spinae had a statistically significant difference between ST and US (p<0.05). Conclusions: The plank exercise strengthens the core muscles effectively, and muscle activity is related to the posture of the exercise and the location of the muscle. These results suggest that plank exercises improve muscle activities. Additionally, plank exercises can be applied to general medical care.

      • 흡입관이 부착된 이젝터의 효과에 관한 연구

        이행남(HaengNam Lee),박길문(GilMoon Park),박지만(JiMan Park),이덕구(DukGu Lee),설재림(JaeLim Sui) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

        The Ejector is used to get low pressure, and it has been applied to a lot of industry field like the heat engine, the fluid instrument power plant, the food industry, environment industry etc... because there are not any problem even it is mixed with a any kind of liquid, gas, and solid. The flow characteristics in ejector are investigated by PIV and CFD. The experiment using PlY measurement for mixing pipe's flow characteristics acquired velocity distribution, .Condition :when mixing pipe's diameter ratio is 1: 1.9, and the flux is<br/> Q₁= 1.136?? /s, Q₂ = 1.706 ?? /s, Q₃ = 2.276?? /s . Based on the PIV and the CFD results, the flow characteristics in ejector are discussed, and it shows the validity of this study.<br/>

      • 흡입관에 부착된 디퓨저 효과에 대한 연구

        이행남(HaengNam Lee),박길문(GilMoon Park),박지만(JiMan Park),이덕구(DukGu Lee),설재림(JaeLim Sul) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

        The diffuser is used to get low pressure, and it has been applied to a lot of industry field like the heat engine, the fluid instrument power plant, the food industry, environment industry etc ... because there are not any problem even it is mixed with a any kind of liquid, gas, and solid. The flow characteristics in diffuser are investigated by PIV and CFD. The experiment using PIV measurement for mixing pipe's flow characteristics acquired velocity distribution,. Condition : when mixing pipe's diameter ratio is 1:2.3, and the flux is Q₁ = 1.136 ℓ/s, Q₂ = 1.706 ℓ/s, Q₃ = 2.276 ℓ/s. Based on the PIV and the CFD results, the flow characteristics in ejector are discussed, and it shows the validity of this study.

      • SSCISCOPUSKCI등재

        Survey Research on the Status of Job Creation and Related Programs for Elderly Women in Korea

        Jaelim Oh,Sook-Jeong Lee 숙명여자대학교 아시아여성연구원 2009 Asian Women Vol.25 No.4

        This study examined problems concerning the elderly and related characteristics as perceived by the frontline officials in charge at senior employment assistance agencies - all based on the recognition of the need to reinforce the expertise of workers. It also examined the educational needs regarding the kind of educational programs that must be provided to help these people develop expertise in related fields. In order to accomplish the purposes of the study, the researchers distributed questionnaires to officials in government and public offices, including the Korean Senior Citizens Association, Senior Welfare Center, Seoul Senior Employment Center and Employment Service Center, from November to December in 2008. The result shows that there are differences in purposes, targets, activities and achievements of employment assistance organizations for elderly people, which result in inefficiency and ineffectiveness. The organizations that conduct employment assistance programs for the elderly have few, if any, experts who adequately understand the particular characteristics of elderly people and who can operate and manage diverse employment programs; moreover, the capacity and skills of such experts are at beginners’ levels in terms of planning, coordination and control functions. The officials need an understanding of the developmental and psychological characteristics of female and male senior citizens that result in differentiated education strategies and programs and the creation of diverse jobs; accordingly, they urged the provision of specific and continuous education of working-level officials in charge. As such, a top priority is education to boost the capacity of working-level officials in charge, who can carry out educational programs for creating jobs that specifically cater to female seniors; to this end, national and local governments should extend steadfast and systematic assistance.

      • SCOPUSKCI등재

        Medical Care Utilization During 1 Year Prior to Death in Suicides Motivated by Physical Illnesses

        Cho, Jaelim,Lee, Won Joon,Moon, Ki Tae,Suh, Mina,Sohn, Jungwoo,Ha, Kyoung Hwa,Kim, Changsoo,Shin, Dong Chun,Jung, Sang Hyuk The Korean Society for Preventive Medicine 2013 예방의학회지 Vol.46 No.3

        Objectives: Many epidemiological studies have suggested that a variety of medical illnesses are associated with suicide. Investigating the time-varying pattern of medical care utilization prior to death in suicides motivated by physical illnesses would be helpful for developing suicide prevention programs for patients with physical illnesses. Methods: Suicides motivated by physical illnesses were identified by the investigator's note from the National Police Agency, which was linked to the data from the Health Insurance Review and Assessment. We investigated the time-varying patterns of medical care utilization during 1 year prior to suicide using repeated-measures data analysis after adjustment for age, gender, area of residence, and socioeconomic status. Results: Among 1994 suicides for physical illness, 1893 (94.9%) suicides contacted any medical care services and 445 (22.3%) suicides contacted mental health care during 1 year prior to suicide. The number of medical care visits and individual medical expenditures increased as the date of suicide approached (p<0.001). The number of medical care visits for psychiatric disorders prior to suicide significantly increased only in 40- to 64-year-old men (p=0.002), women <40 years old (p=0.011) and women 40 to 64 years old (p= 0.021) after adjustment for residence, socioeconomic status, and morbidity. Conclusions: Most of the suicides motivated by physical illnesses contacted medical care during 1 year prior to suicide, but many of them did not undergo psychiatric evaluation. This underscores the need for programs to provide psychosocial support to patients with physical illnesses.

      • KCI등재

        Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation

        Cho Jaelim,Jang Heeseon,Noh Young,Lee Seung-Koo,Koh Sang-Baek,Kim Sun-Young,Kim Changsoo 대한의학회 2023 Journal of Korean medical science Vol.38 No.16

        Background: Numerous studies have shown the effect of particulate matter exposure on brain imaging markers. However, little evidence exists about whether the effect differs by the level of low-grade chronic systemic inflammation. We investigated whether the level of c-reactive protein (CRP, a marker of systemic inflammation) modifies the associations of particulate matter exposures with brain cortical gray matter thickness and white matter hyperintensities (WMH). Methods: We conducted a cross-sectional study of baseline data from a prospective cohort study including adults with no dementia or stroke. Long-term concentrations of particulate matter ≤ 10 µm in diameter (PM10) and ≤ 2.5 µm (PM2.5) at each participant’s home address were estimated. Global cortical thickness (n = 874) and WMH volumes (n = 397) were estimated from brain magnetic resonance images. We built linear and logistic regression models for cortical thickness and WMH volumes (higher versus lower than median), respectively. Significance of difference in the association between the CRP group (higher versus lower than median) was expressed as P for interaction. Results: Particulate matter exposures were significantly associated with a reduced global cortical thickness only in the higher CRP group among men (P for interaction = 0.015 for PM10 and 0.006 for PM2.5). A 10 μg/m3 increase in PM10 was associated with the higher volumes of total WMH (odds ratio, 1.78; 95% confidence interval, 1.07–2.97) and periventricular WMH (2.00; 1.20–3.33). A 1 μg/m3 increase in PM2.5 was associated with the higher volume of periventricular WMH (odds ratio, 1.66; 95% confidence interval, 1.08–2.56). These associations did not significantly differ by the level of high sensitivity CRP. Conclusion: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.

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