고차원 색인 구조를 위한 벌크 삽입

복경수,송석일,유재수 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.1

최근 고차원 데이터를 위한 다양한 색인 구조에 대한 연구가 진행되어 왔다. 지리정보 시스템, 내용기반 이미지 검색 등과 같은 응용분야에서는 일반적으로 색인 구성 후 추가적으로 발생하는 데이터 역시 대량으로 삽입되는 경우가 빈번하다. 대량의 데이터를 하나씩 삽입하게 되면 삽입하기 위해 소요되는 시간과 검색 성능의 저하를 발생시킨다. 이러한 문제점을 해결하고자 다양한 벌크 삽입 기법들이 제시되었다. 벌크 삽입의 목적은 삽입 시간을 단축시키고 검색 성능을 향상시키는 것이다. 그러나 기존의 벌크 삽입 기법들은 한쪽에 군집된 데이터만을 고려하거나 또는 기존의 색인 구조에 존재하는 MBR을 고려하지 않고 있다. 본 논문에서는 일반적인 경우에도 좋은 검색 성능을 보장하고 데이터의 삽입으로 MBR들간의 겹침을 최소화하기 위한 새로운 벌크 삽입 알고리즘을 제안한다. Recently, various high-dimensional index structures have been proposed. Generally, in the applications such as geographic information System, content-based image retrieval and so on, large amount of data are presented to be inserted into existing index structures. Inserting each data item one bye one is very inefficient in terms of insertion time and query performance. In that reason various bulk insertion techniques are proposed to solve the problem. The purpose of bulk insertion speeds up insertion time and improves query performance. However the existing methods perform only for highly skewed data and do not consider existing MBRs of index structures when data objects are inserted. In this paper, we design a bulk insertion algorithm that performs well for general case and minimizes overlap between newly inserted objects and existing MBRs.

각종 악성종양질환에서의 세포면역 기능에 대한 연구 : 말초 혈액 T 임파구 아형 분포 및 지연형 과민반응에 대한 검색 Delayed Cutaneous Hypersensitivity and Peripheral Blood T-lymphocyte Subsets

송재화,이복희 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

The author studied delayed cutaneous hypersensitivity and peripheral blood T-lymphocyte subpopulations in 54 patients with malignant tumors. 1. The number and total score of positive reactions in delayed cutaneous hypersensitivity were significantly decreased in cancer patients(p<0.005, p<0.05). 2. Percent OKT4^+ T-lymphocyte in cancer patients were significantly decreased compared to normal control subjects (p <0. 05), and it had positive correlation with total score of delayed cutaneous hypersensitivity reactions(r=0.768). 3. Percent OKT8^+ cells were not different from that of normal control subjects. 4. The ratio of OKT4^+/OKT8^+ in cancer patients were not different from that of normal control subjects except in patients with colorectal carcinoma and malignant lymphomas. 5. Markers of activated T-lymphocyte, OKT10^+ and OKIal^+ cells were increased in all the patient groups. 6. Leu7^+ cells, reflecting natural killer cells, were not different from normal control subjects These results suggest that the cancer patients have depressed cellular immune functions, which mainly results from the decrease of helper T lymphocyte number. Short of functional assays of cellular immunity, the author concluded that the testing of delayed cutaneous hypersensitivity and enumeration of peripheral blood lymphocyte subsets, especially OKT4^+ cells and activated T cells provide useful informations on cellular immune reactivity in cancer patients. Further studies on prognostic value of these parameters should be pursued.

Baculovirus를 이용한 Aujeszky's Disease Virus gⅢ 단백질 발현

송재영,이중복,현방훈,박종현,김병한,권창희,전무형,안수환 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-

The g Ⅲ gene located in U_L region of Yangsan strain, a field isolate of Aujeszky's disease virus (ADV) in Korea, was cloned into pTZ18R and sequenced. The gⅢ gene consisting of 1,437 nucleotides showed 98% sequence homology with that of Becker strain, a reference strain of ADV. The gene encoding gⅢ of Yangsan strain was placed under the control of Autographa californica nucleopolyhedrosis virus (AcNPV) polyhedrin promoter, and expressed by the derived recombinant baculovirus using Spodoptera frugiperda 9 (Sf9) cells. The expressed gⅢ was a protein with molecular weight of 72kd determined by immunoprecipitation and Western blotting assay using anti-ADV polyclonal antibodies and anti-gⅢ monoclonal antibody. The partially purified gⅢ protein was utilized as antigen in the radial immunodiffusion enzyme assay (RIDEA) to detect to specific antibody against ADV in pig sera. The results indicated that the sensitivity of RIDEA with the recombinant gⅢ protein antigen (98%) was as high as that with the conventional glycoprotein antigen extracted from the ADV infected cells. In addition, the false positive and false nagative reactions in gⅢ RIDEA were significantly reduced than the conventional glycoprotein RIDEA as judged from the results of standard serum neutralization test.

기업부설연구소의 연구성과 사업화 및 확산방안에 관한 연구

송재복,류호상 안성산업대학교 2002 論文集 Vol.34 No.-

This study will focus on how to convert the research results into money-making business and how to spread them to other businesses through technology transaction and co-work, as well as what the role of government should be in this process. For these purposes, the actual conditions and the existing problems of research institutions will be first estimated. Finally, the study will find out the maximum measure to utilize the research results in the process of monopolized commercialization by a single company and in the process of joint utilization among companies. In addition, the question about how the government should support the process will be answered.

CoNbZr/Cu/CoNbZr 다층박막의 습식 식각 거동에 관한 연구

윤재홍,김현식,송재성,이영생,민복기 國立 昌原大學校 産業技術硏究所 1997 産技硏論文集 Vol.11 No.-

We manufactured CNZ/Cu/CNZ multi-layers by sputtering methode and formed pattern on the deposited multi-layers. In this study, we fabricated new etchant for the etching to formed pattern by the wet chemical etchant. it was searching for the best condition of etchant. Cu was etched selectively independence in the concentration of basic solution but amorphous CNZ thin film did not. The etchant was achieved by basic solution(17.5 mol%) and HF(20mol%) mixing, which etched CNZ/Cu/CNZ multi-layers in the same. Also, the etchant etched CNZ/Cu/CNZ multi-layers by the three-step. It was shown that the etched cross-section have isotropic structure and excellent etching characteristics.

^(7)Li, ^(87)Rb과 ^(27)Al NMR을 이용한 (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6)와 K_(2)SnCl_(6):Al^(3+)의 상전이 근처에서의 결정 동력학 연구

김복수,김영훈,강재필,백아영,차유정,김민경,서용문,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

K_(2)SnCl_(6)는 antifluoride계에 속하는 결정으로서 K_(2)SnCl_(6)에 Li^(+)를 첨가하여 ^(7)Li 핵자기공명(NMR)을 측정하여 동형(isomorphic) 혼합결정(K_(1-x)Rb_(x))_(2)SnCl_(6)와 비동형(nonisomorphic) 혼합결정 K_(2)SnCl_(6):Al^(3+)에서의 핵자기공명(NMR), ^(87)Rb NMR과 ^(27)Al NMR의 측정값과 비교하였다. Rb^(+) 이온은 K_(2)SnCl_(6)의 K^(+)이온을 대신해 동형 결정을 이루며, Al^(3+)이온은 Sn^(4+)이온을 대치하면서 비동형 결정을 이루는데 Li^(+)이온 또한 K^(+)이온을 대신하는 동형 혼합결정과 유사한 결과 값을 얻을 수 있었다. 이 연구 결과는 종래의 Cl-NQR 연구 결과와 비교함으로서 K_(2)SnCl_(6)의 동력학적 특성과 구조 상전이 근처에서의 임계현상을 새로운 관점에서 볼 수 있는 가능성을 보여주었다. ^(7)Li, ^(87)Rb and ^(27)Al NMR have been investigated in the isomorphic and nonisomorphic impurity doped crystals (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6) and K_(2)SnCl_(6):Al^(3+) as a supplementary to the previous Cl NQR studies in these crystals. The results yielded that the features of NMR spectra for both types of crystals are roughly in line with the systematic trends shown in the Cl NQR in these crystals, though the outstanding characteristics exhibited in the Cl NQR become in the case of the NMR of the doped impurities in crystals somewhat weakend. This is due to the degradation of the role of the local field from the main hamiltonian in NQR to the subsidiary in NMR. Each NMR result of the iso/nonisomorphic crystals has been analyzed in terms of the 'impurity induced dynamic lattice defects' for K_(2)SnCl_(6):Al^(3+) and the 'static primary impurity effects' for (K_(1-x)Rb_(x))_(2)SnCl_(6) and (K_(1-x)Li_(x))_(2)SnCl_(6) respectlvely.

Pocine Adenovirus-3의 E1B Region의 鹽基序列 分析

朴鍾賢,宋載永,李重馥,玄芳勳,安東濬,車相昊,裵用泰,姜永源,Reddy, P S,全茂炯,安壽煥 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

돼지 아데노바이러스(PAV-3). 6618주의 EIB region이 包含되어 있는 map unit 4.0에서 9.7까지의 유전자에 대한 1,984 bp의 염기서열을 決定하였으며, 이 結果를 알려진 여러 아데노바이러스 유전자와 비교하여 다음과 같은 결과를 얻었다. 1. PAV-3의 EIB유전자는 10개의 ORF로 구성되어 있으며, 그 중 아데노바이러스의 단백질과 유사성이 있는 것은 ORF1, ORF2 및 ORF3이었다. ORF1은 Ad41의 19kd 와 BAV-2에서의 EIB ORF2에서의 아미노산의 一致率은 각각 32%와 31%이었다. 2. ORF2는 Ad2 55kd protein과 tupaia adenovirus 44kd protein가 각각 34%로 아미노산 一致率이 가장 높았으며, Ad41의 52kd protein. BAV-3의 EIB ORF3에서도 33%의 一致率을 보였다. 3. ORF1은 61-666 uncleotide (606 bp), ORF 2에서는 429-1,850 uncleotide (1,422 bp)의 부위로 각각 202, 474 a.a로 構成되었으며, 예상되는 분자량은 20 kd와 52 kd이었다. 4. ORF3는 hexon-associated pIX유전자로 추정되며 내부에 1개의 polyadenylation signal(ATAAA)이 1938-1942 uncleotide에 위치하였으며, 이 부위는 TATA box (1937-1942 uncleotide)와 중복되어 존재하였다. Porcine adenovirus type 3 (PAV-3) does not cause severe infection in pigs. Adenovirus has been suggestive of live vaccine vector carrying foreign gene. One of insertion regions is delayed early (EIB) region. However, EIB region of PAV-3 has not been molecularly characterized to date. Nucleotide sequence of EIB of PAV-3 was determined. The EIB region was composed of 1,984 bp and located between 4.0 and 9.7 map units. Three potential open reading frames(ORFs) with low level of homology to other adenoviruses and a polyadenylation signal were identified in the rightward direction of genome. The nucleotide and the predicted amino acid sequences of EIB were compared to those of human and animal adenoviruses. One of the three potential ORFs. ORF1 encoded a polypeptide homologous to bovine adenovirus type 2(BAV-2) ORF2 and human adenovirus type 41(Ad41) 19 kd protein. ORF2 encoded a polypeptide homologous to human adenovirus type 2(Ad2) 55 kd protein, bovine adenovirus type 3(BAV-3) ORF3 and porcine adenovirus type 4(PAV-4) ORF2. The predicted protein of ORF1 had homology to those of Ad41 and BAV-2 with 32 and 31% respectively, whereas the deduced protein of ORF2 had homology to those of Ad2. BAV-3 and PAV-4 with 34, 33 and 29%, respectively.

국내에서 분리된 canine parvovirus의 구조유전자 cloning과 염기서열 분석

박종현,송재영,이중복,현방훈,안수환,전무형 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-

In this study gene encoding structural proteins of a CPV isolate was cloned and saquenced to elucidate the molecular genetical properties of the canine parvoviruses isolated from the field. Six recombinant plasmids of pEP3, p1471, p2070, pEP069, pEP338 and p14711p were constructed from the map positions 22 to 98 of RF DNA to clone the VP1 and VP2 genes of CPV-V20. Sequentialy the gene comprising 3780 nucleotides were sequenced by dideoxy chain termination method. When nucleotide sequence of gene encoding the structural proteins of CPV-V20 was compared with those of other strains, CPV-N, CPV-d and CPV-780929 published previously. DNA homologies to CPV-V20 were 99.87% with CPV-NM, 99.73% with CPV-d, 96.85% with CPV-780929 AND 98.4% with FPLV-Carl, respectively. The DNA sequence data of CPV-V20 showed seven point mutations and also deletion of 135 nucleotides from the nucleotide position 4745 to 4879 located in the 3-noncoding region of CPV-N.

고용량 및 저용량 ticlopidine의 혈소판 응집억제 효과 비교: 예비연구

김제,이훈복,송희정,이태용,김재문 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

박막 인덕터와 제조와 DC-DC Converter에의 적용

오영우,민복기,송재성 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-

Thin film inductors of 10 mm×10 mm with inner coil type of 5 turns were fabricated by sputtering, photo-masking, and etching processes. The inductor has an inductance of 585 nH at 1MHz. And to estimate the applicability of the thin film inductors fabricated in this research to DC-DC converters. the test board of DC-DC converters was made. It was a boost type and input voltage of 2.7 to 5 volts. output voltage of 5 volts, and the switching frequency was 1.6 MHz. When the thin film inductor was adopted, the converter was operated normally. and the maximum efficiency was 49 % at the load of 50.5 Ω and the output power was 0.51 W. This result was not satisfactory for practical usage at present, but the switching FET devices for higher frequency use be developed in the near future, and then more higher frequency switching DC-DC converter will adopt these inductors.