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Mondal, S.,Lin, C. C.,Chen, W. P.,Zhang, Z.-W.,Alcock, C.,Axelrod, T.,Bianco, F. B.,Byun, Y.-I.,Coehlo, N. K.,Cook, K. H.,Dave, R.,Kim, D.-W.,King, S.-K.,Lee, T.,Lehner, M. J.,Lin, H.-C.,Marshall, S. American Institute of Physics 2010 The Astronomical journal Vol.139 No.5
<P>The Taiwanese-American Occultation Survey (TAOS) project has collected more than a billion photometric measurements since 2005 January. These sky survey data—covering timescales from a fraction of a second to a few hundred days—are a useful source to study stellar variability. A total of 167 star fields, mostly along the ecliptic plane, have been selected for photometric monitoring with the TAOS telescopes. This paper presents our initial analysis of a search for periodic variable stars from the time-series TAOS data on one particular TAOS field, No. 151 (R.A. = 17<SUP>h</SUP>30<SUP>m</SUP>6<img entity='fs' SRC='http://ej.iop.org/icons/Entities/fs.gif' ALT='fs' ALIGN='BASELINE' />7, decl. = 27°17'30'', J2000), which had been observed over 47 epochs in 2005. A total of 81 candidate variables are identified in the 3 deg<SUP>2</SUP> field, with magnitudes in the range 8 < R < 16. On the basis of the periodicity and shape of the light curves, 29 variables, 15 of which were previously unknown, are classified as RR Lyrae, Cepheid, δ Scuti, SX Phonencis, semi-regular, and eclipsing binaries.</P>
Improving the Gumbel analysis by using M-th highest extremes
Cook, Nicholas J. Techno-Press 1998 Wind and Structures, An International Journal (WAS Vol.1 No.1
Improvements to the Gumbel method of extreme value analysis of wind data made over the last two decades are reviewed and illustrated using sample data for Jersey. A new procedure for extending the Gumbel method to include M-th highest annual extremes is shown to be less effective than the standard method, but leads to a method for calibrating peak-over-threshold methods against the standard Gumbel approach. Peak-over-threshold methods that include at least the 3rd highest annual extremes, specifically the modified Jensen and Franck method and the "Method of independent storms" are shown to give the best estimates of extremes from observations.
Detecting artefacts in analyses of extreme wind speeds
Cook, Nicholas J. Techno-Press 2014 Wind and Structures, An International Journal (WAS Vol.19 No.3
The impact of artefacts in archived wind observations on the design wind speed obtained by extreme value analysis is demonstrated using case studies. A signpost protocol for detecting candidate artefacts is described and its performance assessed by comparing results against previously validated data. The protocol targets artefacts by exploiting the serial correlation between observations. Additional "sieve" algorithms are proposed to identify types of correctable artefact from their "signature" in the data. In extreme value analysis, artefacts displace valid observations only when they are larger, hence always increase the design wind speed. Care must be taken not identify large valid values as artefacts, since their removal will tend to underestimate the design wind speed.
Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes
Cooke, Mariana,Zhou, Xiaoling,Casado-Medrano, Victoria,Lopez-Haber, Cynthia,Baker, Martin J.,Garg, Rachana,Ann, Jihyae,Lee, Jeewoo,Blumberg, Peter M.,Kazanietz, Marcelo G. American Society for Biochemistry and Molecular Bi 2018 The Journal of biological chemistry Vol.293 No.22
<P>Diacylglycerol (DAG) is a key lipid second messenger downstream of cellular receptors that binds to the C1 domain in many regulatory proteins. Protein kinase C (PKC) isoforms constitute the most prominent family of signaling proteins with DAG-responsive C1 domains, but six other families of proteins, including the chimaerins, Ras-guanyl nucleotide-releasing proteins (RasGRPs), and Munc13 isoforms, also play important roles. Their significant involvement in cancer, immunology, and neurobiology has driven intense interest in the C1 domain as a therapeutic target. As with other classes of targets, however, a key issue is the establishment of selectivity. Here, using [H-3]phorbol 12,13-dibutyrate ([H-3]PDBu) competition binding assays, we found that a synthetic DAG-lactone, AJH-836, preferentially binds to the novel PKC isoforms PKC and PKCE relative to classical PKC and PKCII. Assessment of intracellular translocation, a hallmark for PKC activation, revealed that AJH-836 treatment stimulated a striking preferential redistribution of PKCE to the plasma membrane relative to PKC. Moreover, unlike with the prototypical phorbol ester phorbol 12-myristate 13-acetate (PMA), prolonged exposure of cells to AJH-836 selectively down-regulated PKC and PKCE without affecting PKC expression levels. Biologically, AJH-836 induced major changes in cytoskeletal reorganization in lung cancer cells, as determined by the formation of membrane ruffles, via activation of novel PKCs. We conclude that AJH-836 represents a C1 domain ligand with PKC-activating properties distinct from those of natural DAGs and phorbol esters. Our study supports the feasibility of generating selective C1 domain ligands that promote novel biological response patterns.</P>
A photophysical study of PCBM thin films
Cook, S.,Ohkita, H.,Kim, Y.,Benson-Smith, J.J.,Bradley, D.D.C.,Durrant, J.R. North Holland ; Elsevier Science Ltd 2007 Chemical physics letters Vol.445 No.4
Jablonski diagram comparing the energy of the intramolecular and the more delocalised charge transfer states in thin films of PCBM.