http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kinematics and dynamics modeling of the 6-3-PUS-type Hexapod parallel mechanism
Jaqueline Bernal,Ricardo Campa,Israel Soto 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.10
Modeling and analyzing the dynamics of mechanical systems is important for purposes of simulation, design and control. In the case of parallel manipulators, dynamics modeling becomes a complex task mainly due to the constraints imposed by the closed kinematic chains, and several methods have been proposed for solving that problem. Some authors suggest first using a non-minimal set of coordinates and then computing a minimal dynamics model by means of the so-called projection method. This paper reports the use of such procedure for obtaining the dynamics model of a particular parallel mechanism of the type known as 6-3-PUS. To compute the non-minimal dynamics we employed the Euler-Lagrange formulation. The computed kinematics and dynamics models were validated via numerical simulations. This modeling approach can be employed for similar mechanisms.
Macrina Pe´rez-Lo´pez,Rodolfo Garcı´a-Contreras,Marcos Soto-Herna´ndez,Jose´ Salud Rodrı´guez-Zavala,Mariano Martı´nez-Va´zquez,Francisco Javier Prado-Galbarro,Israel Castillo-Jua´rez 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.4
Seed oils from oleaginous plants are rich in fatty acids (FAs) that play important roles in the health of the consumers. Recent studies indicate that FA also can play an important role in communication and regulation of virulence in bacteria. Nevertheless, evidence demonstrating protection against bacterial infections mediated by their quorum sensing inhibition (QSI) activity is scarce. In this study, sunflower, chia, and amaranth oils, were assayed for their QSI capacity by inhibiting violacein production and alkaline exoprotease activity of Chromobacterium violaceum. In vitro assays revealed that the oils exhibited QSI activities, whereas in vivo they delayed death of mice inoculated intraperitoneally with the bacterium. Gas chromatography coupled with mass spectrometry analysis of the oils indicated the presence of saturated FA (SAFA) and unsaturated FA as main components. Through a structure–activity relationship study of free FAs, bactericidal effect was identified mainly for polyunsaturated FAs, whereas QSI activity was restricted to SAFA of chains 12–18 carbon atoms in length. These data correlate with a possible interaction suggested by molecular docking analysis of lauric, myristic, and stearic acids with the CviR protein. Our study highlights the antiquorum sensing potential of SAFA, which may be future antivirulence therapeutic agents for the treatment of bacterial infections.