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Amelioration of sepsis by TIE2 activation–induced vascular protection
Han, Sangyeul,Lee, Seung-Jun,Kim, Kyung Eun,Lee, Hyo Seon,Oh, Nuri,Park, Inwon,Ko, Eun,Oh, Seung Ja,Lee, Yoon-Sook,Kim, David,Lee, Seungjoo,Lee, Dae Hyun,Lee, Kwang-Hoon,Chae, Su Young,Lee, Jung-Hoon American Association for the Advancement of Scienc 2016 Science translational medicine Vol.8 No.335
<P>Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti-angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers clustering of ANG2, assembling an ABTAA/ANG2 complex that can subsequently bind and activate TIE2. Compared with a conventional ANG2-blocking antibody, ABTAA was highly effective in augmenting survival from sepsis by strengthening the endothelial glycocalyx, reducing cytokine storms, vascular leakage, and rarefaction, and mitigating organ damage. Together, our data advance the role of TIE2 activation in ameliorating sepsis progression and open a potential therapeutic avenue for sepsis to address the lack of sepsisspecific treatment.</P>
이인원(Inwon Lee),이기두(Kidu Lee),박영근(Youngkuen Park),임상수(Sangsoo Lim),백승욱(Seungwoock Baek),이대열(Daeyearl Lee) 한국항공우주학회 2013 韓國航空宇宙學會誌 Vol.41 No.4
국내 최초로 개발되는 공대지 유도키트에 대하여 미국의 MIL-HDBK 및 STANDARD를 준용한 시험을 성공적으로 수행하였다. 각종 지상시험을 통하여 유도키트의 작동 성능과 내구성을 검증하였으며, 유도키트를 일반목적폭탄에 장착한 활공탄으로 비행시험을 수행하여 중거리 활공비행성능 및 정확도가 매우 양호함을 확인하였다. Tests and evaluations following the U.S. MIL-HDBK/STANDARD were successfully conducted to assure the performance of the air-to-surface guidance kit which was developed first in Korea. Various ground tests confirmed the operation capability and reliability of the guidance kit, and flight tests proved very good mid-range gliding performance and accuracy of the gliding bomb which was a general purpose bomb with the guidance kit.
Lee, Cheol-Min,Seo, Jin-Hyeok,Yu, Jin-Won,Choi, Jung-Eun,Lee, Inwon The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
This paper employs computational tools to predict power increase (or speed loss) and propulsion performances in waves of KVLCC2. Two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved using finite volume method; and a realizable k-ε model has been applied for the turbulent closure. The free-surface is obtained by solving a VOF equation. Sliding mesh method is applied to simulate the flow around an operating propeller. Towing and self-propulsion computations in calm water are carried out to obtain the towing force, propeller rotating speed, thrust and torque at the self-propulsion point. Towing computations in waves are performed to obtain the added resistance. The regular short head waves of λ/LPP = 0.6 with 4 wave steepness of H/λ = 0.007, 0.017, 0.023 and 0.033 are taken into account. Four methods to predict speed-power relationship in waves are discussed; Taylor expansion, direct powering, load variation, resistance and thrust identity methods. In the load variation method, the revised ITTC-78 method based on the 'thrust identity' is utilized to predict propulsive performances in full scale. The propulsion performances in waves including propeller rotating speed, thrust, torque, thrust deduction and wake fraction, propeller advance coefficient, hull, propeller open water, relative rotative and propulsive efficiencies, and delivered power are investigated.
Alternative Plans for High Speed Railway System : The Case of South Korea
Lee, Inwon,Kang, Junmo,Kim, Hyunmoo Research Institute for Science & Technology HONG-I 2002 Hongik Journal of Science and Technology Vol.6 No.-
The first high speed railway line is now under construction from Seoul to Pusan. Currently, the route design problem for the second and the third line brought up many issues in regional development planning. This paper summarizes experiences with the High Speed Railway Network Design problem. Quantitative methods such as AHP (Analytical Hierarchical Processing) and matrix evaluation are useful for multi-criteria evaluation but have limited use when searching for the best possible network plan. Regional development issues, political consideration, and future adaptability for further extension to China or Siberia are as important as considering financial, economical, technical, engineering, and environmental criteria for railway network design. In Korea the cruci-form network is preferred to the radial K pattern, the ladder H form, or the U pattern in the regional development aspect. These arguments are explained based on studies carried out in Korea. The 7*9 Korean national expressway network was planned to allow access to the system in 30 minutes from every city in Korea while the cruci-form High Speed Railway network system was proposed to reduce external diseconomies generated from the activity concentration on the Seoul metropolitan region. It is believed that the cruci-form network system will provide balanced regional growth and high patronage as well.
Lee, Cheol-Min,Yu, Jin-Won,Choi, Jung-Eun,Lee, Inwon The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
This paper employs computational tools to investigate the cause of resistance reductions in calm water and waves of the sharp bow form compared to the blunt bow in 66,000 DWT bulk carriers. A more slender shape at the fore-shoulder without a bulbous bow is a prominent feature of the sharp bow. The blunt bow incorporates a bulbous shape. A two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved; and a realizable k-ε model has been applied for the turbulent closure. The free-surface is obtained by solving a VOF equation. The computational results have been validated with model tests carried out at a towing tank. The pressure component of resistance in the sharp bow is reduced by 8.9% in calm water, and 6.4-12.7% in regular head waves. The frictional components of resistance in the sharp and blunt bows are largely the same.
The Transient Response Characteristics of Compliant Coating to Pressure Fluctuations
Inwon Lee,Ho Hwan Chun,Jin Kim 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.4
The amplitude and phase lag of surface deformation were determined for a compliant coating under the action of turbulent pressure fluctuations. For this purpose, pressure fluctuations were measured experimentally. The amplitude and duration of coherent wave train of pressure fluctuations were investigated using digital filtration. The transient response was calculated for stabilization of forced oscillations of the coating in approximation of local deformation. The response of coating was analyzed with considerations of its inertial properties and limited duration of coherent harmonics action of pressure fluctuations. It is shown that a compliant coating interacts not with the whole spectrum of pressure fluctuations, but only with a frequency range near the first resonance. According to the analysis, with increasing elasticity modulus of the coating material E, deformation amplitude decreases as 1/E, and dimensionless velocity of the coating surface decreases as 1/√E. For sufficiently hard coatings, deformation amplitude becomes smaller than the thickness of viscous sublayer, while surface velocity remains comparable to vertical velocity fluctuations of the flow.
THE WIN-WIN SOLUTION FOR MOBILITY AND ENVIRONMENTAL QUALITY
Inwon Lee,Eunmi Park,Joo-heon Lee 대한교통학회 1998 대한교통학회 기타자료 Vol.1998 No.-
The current increases in fuel price contribute to reducing level of congestion and air pollution. In this paper, this measure is compared with the congestion toll charge and the 10 "buje"(a 10% demand control measure of registered vehicle i.e. each vehicle can not operate when its plate's last digit matches the last digit of the date). The purpose of our study is to give a priority order to various measures and to propose the win-win solution of Seoul for policy makers. We recommend the congestion toll charge coupled with some metering measures is the win-win solution for Seoul. Also we conclude a priority order such as metering; congestion toll charge; increase in parking fee; increase in fuel price; the 10 "buje" must be acceptable for implementation. Various ITS subsystems needed to support the proposed win-win solution are identified and field operational tests for them are introduced in this paper.
Effects of diffraction in regular head waves on added resistance and wake using CFD
Lee, Cheol-Min,Park, Sung-Chul,Yu, Jin-Won,Choi, Jung-Eun,Lee, Inwon The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
This paper employs computational tools to investigate the diffraction effects in regular head waves on the added resistance and wake on the propeller plane. The objective ships are a 66,000 DWT bulk carrier and a 3,600 TEU container ship. Fixed and free to heave and pitch conditions at design speed have been taken into account. Two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved using the finite volume method; and a realizable k-ε model has been applied for the turbulent closure. The free surface is obtained by solving a VOF equation. The computations are carried out at the same scale of the model tests. Grid and numerical wave damping zones are applied to remove unwanted wave reflection at the boundaries. The computational results are analyzed using the Fourier series. The added resistances in waves at the free condition are higher than those at the fixed condition, which are nearly constant for all wavelengths. The wake velocity in waves is higher than that in calm water, and is accelerated where the wave crest locates on the propeller plane. When the vertical motion at the stern goes upward, the wake velocity also accelerated.