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마그네슘을 6 wt.% 함유한 알루미늄 합금의 저항 점용접성 평가
김민규(Mingyu Kim),김세현(Sehyeon Kim),황인성(Insung Hwang),김동윤(Dong-Yoon Kim),김영민(Young-Min Kim),이승환(Seung Hwan Lee),유지영(Jiyoung Yu) 대한용접·접합학회 2021 대한용접·접합학회지 Vol.39 No.5
To ensure safety and reduce the weight of vehicles, studies are being actively conducted on different aluminum alloys that have strength higher than conventional aluminum alloys. The development of high-performance aluminum alloys through magnesium content control is underway. Research on manufacturing techniques, such as, welding for application to the car body parts of these materials is required. In this study, the resistance spot weldability of an aluminum alloy with 6 wt.% magnesium (Al-6Mg) was evaluated and compared with the commercial aluminum alloy 5052, 6061 (Al5052, Al6061). The suitable welding range of the Al-6Mg was found to have a welding current of 24 ㎄ to 28 ㎄, and a similar level of Al6061. The welding heat input was almost the same for the three materials, which resulted in no difference in the diameter of the nuggets. There was no significant difference of the porosity ratio between Al-6Mg and Al5052; however, the porosity ratio of Al6061 was higher. The alloy with the highest tensile shear strength, hardness and energy absorption of a welded joint was Al-6Mg. The low porosity ratio and high hardness of the Al-6Mg alloy caused the relatively high tensile shear strength and energy absorption of the welded joint.
Kim, Young-Rang,Kim, Young Hye,Kim, Sung Woo,Lee, Yong Ju,Chae, Dong-Eon,Kim, Kyung-A,Lee, Zee-Won,Kim, Nam Doo,Choi, Jong-Soon,Choi, Insung S.,Lee, Kyung-Bok The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.79
<P>Herein, we present a simple readout of the binding between a chemical drug and its target proteins in the cytoplasm by using a two-step bioorthogonal labeling method combined with spatially-localized expression of proteins. Dasatinib was modified with transcyclooctene (TCO), and its cytoplasmic target kinases were expressed in intracellular compartments, such as endosomes and F-actins. After bioorthogonal labeling, the colocalization between Dasatinib and its target proteins was observed in intracellular compartments.</P>
Biomimetic Micropatterning of Silica by Surface-Initiated Polymerization and Microcontact Printing
Kim, Dong ,Jin,Lee, Kyung-Bok,Lee, Tae ,Geol,Shon, Hyun ,Kyong,Kim, Wan-Joong,Paik, Hyun-jong,Choi, Insung ,S. WILEY-VCH Verlag 2005 Small Vol.1 No.10
<P>Micropatterns of silica on a gold substrate were generated by a biomimetic approach, namely, the biosilicification of silicic acids. The procedure consists of three simple steps: pattern generation of a polymerization initiator, (BrC(CH<SUB>3</SUB>)<SUB>2</SUB>COO(CH<SUB>2</SUB>)<SUB>11</SUB>S)<SUB>2</SUB>, by microcontact printing; surface-initiated, atom-transfer radical polymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA) from the patterned area; and polycondensation of silicic acids. The tertiary amine-containing polymer, pDMAEMA, aided in the spatially controlled polycondensation of silicic acids on surfaces in the presence of phosphate ions, and micropatterns of silica on a gold substrate were successfully generated in combination with the technique of microcontact printing. The procedure could be extended to the controlled fabrication of silica patterns with any size, shape, or thickness.</P> <B>Graphic Abstract</B> <P>A synthetic counterpart to silaffins in diatoms, pDMAEMA, was grown from a gold surface by pattern generation of a polymerization initiator and surface-initiated, atom-transfer radical polymerization. The patterns of pDMAEMA were utilized to generate patterns of silica on the surface by a biomimetic approach (see optical images). <img src='wiley_img/16136810-2005-1-10-SMLL200400157-content.gif' alt='wiley_img/16136810-2005-1-10-SMLL200400157-content'> </P>
Kim, Bo-Eun,Choi, Soon Won,Shin, Ji-Hee,Kim, Jae-Jun,Kang, Insung,Lee, Byung-Chul,Lee, Jin Young,Kook, Myoung Geun,Kang, Kyung-Sun Cognizant Communication Corp. 2018 CELL TRANSPLANTATION Vol. No.
<P>Neural stem cells (NSCs) are a prominent cell source for understanding neural pathogenesis and for developing therapeutic applications to treat neurodegenerative disease because of their regenerative capacity and multipotency. Recently, a variety of cellular reprogramming technologies have been developed to facilitate <I>in vitro</I> generation of NSCs, called induced NSCs (iNSCs). However, the genetic safety aspects of established virus-based reprogramming methods have been considered, and non-integrating reprogramming methods have been developed. Reprogramming with <I>in vitro</I> transcribed (IVT) mRNA is one of the genetically safe reprogramming methods because exogenous mRNA temporally exists in the cell and is not integrated into the chromosome. Here, we successfully generated expandable iNSCs from human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) via transfection with IVT mRNA encoding SOX2 (SOX2 mRNA) with properly optimized conditions. We confirmed that generated human UCB-MSC-derived iNSCs (UM-iNSCs) possess characteristics of NSCs, including multipotency and self-renewal capacity. Additionally, we transfected human dermal fibroblasts (HDFs) with SOX2 mRNA. Compared with human embryonic stem cell-derived NSCs, HDFs transfected with SOX2 mRNA exhibited neural reprogramming with similar morphologies and NSC-enriched mRNA levels, but they showed limited proliferation ability. Our results demonstrated that human UCB-MSCs can be used for direct reprogramming into NSCs through transfection with IVT mRNA encoding a single factor, which provides an integration-free reprogramming tool for future therapeutic application.</P>
Kim, Dong Jin,Kang, Sung Min,Kong, Bokyung,Kim, Wan-Joong,Paik, Hyun-jong,Choi, Hyeon,Choi, Insung S. WILEY-VCH Verlag 2005 Macromolecular chemistry and physics Vol.206 No.19
<P>Summary: We investigated the formation of thermoresponsive gold nanoparticle/poly(N-isopropylacrylamide) (AuNP/PNIPAAm) core/shell hybrid structures by surface-initiated, atom transfer radical polymerization (SI-ATRP) in aqueous media and the effect of cross-linking on the thermoresponsiveness of the AuNP/PNIPAAm hybrids. The disulfide containing an ATRP initiator was attached onto AuNPs and the monomer, NIPAAm, was polymerized from the surface of AuNPs in the absence or presence of a cross-linker, ethylene diacrylate, in aqueous media at room temperature. The resulting brush-type and cross-linked AuNP/PNIPAAm hybrids were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and variable temperature dynamic light scattering.</P><P> <img src='wiley_img/10221352-2005-206-19-MACP200500268-gra001.gif' alt='wiley_img/10221352-2005-206-19-MACP200500268-gra001'> Graphic </P>
Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns
Kim, Seong-Min,Lee, Seyeong,Kim, Dongyoon,Kang, Dong-Hee,Yang, Kisuk,Cho, Seung-Woo,Lee, Jin Seok,Choi, Insung S.,Kang, Kyungtae,Yoon, Myung-Han SPRINGER SCIENCE + BUSINESS MEDIA 2018 NANO RESEARCH Vol.11 No.5