http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling
Kim, Kangsan,Kim, Il-Kug,Yang, Jee Myung,Lee, Eunhyeong,Koh, Bong Ihn,Song, Sukhyun,Park, Junseong,Lee, Sungsu,Choi, Chulhee,Kim, Jin Woo,Kubota, Yoshiaki,Koh, Gou Young,Kim, Injune Grune & Stratton 2016 Circulation research Vol.119 No.7
<P>Rationale: Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback is well known, the positive feedback control for augmenting VEGF signaling remains poorly understood. Transcription factor Sox17 is indispensable for angiogenesis, but its association with VEGF signaling is largely unknown. The contribution of other Sox members to angiogenesis also remains to be determined. Objective: To reveal the genetic interaction of Sox7, another Sox member, with Sox17 in developmental angiogenesis and their functional relationship with VEGF signaling. Methods and Results: Sox7 is expressed specifically in endothelial cells and its global and endothelial-specific deletion resulted in embryonic lethality with severely impaired angiogenesis in mice, substantially overlapping with Sox17 in both expression and function. Interestingly, compound heterozygosity for Sox7 and Sox17 phenocopied vascular defects of Sox7 or Sox17 homozygous knockout, indicating that the genetic cooperation of Sox7 and Sox17 is sensitive to their combined gene dosage. VEGF signaling upregulated both Sox7 and Sox17 expression in angiogenesis via mTOR pathway. Furthermore, Sox7 and Sox17 promoted VEGFR2 (VEGF receptor 2) expression in angiogenic vessels, suggesting a positive feedback loop between VEGF signaling and SoxF. Conclusions: Our findings demonstrate that SoxF transcription factors are indispensable players in developmental angiogenesis by acting as positive feedback regulators of VEGF signaling.</P>
Kim, Hyunsoo,Yu, Su Jong,Yeo, Injun,Cho, Young Youn,Lee, Dong Hyeon,Cho, Yuri,Cho, Eun Ju,Lee, Jeong-Hoon,Kim, Yoon Jun,Lee, Sungyoung,Jun, Jongsoo,Park, Taesung,Yoon, Jung-Hwan,Kim, Youngsoo American Society for Biochemistry and Molecular Bi 2017 Molecular and Cellular Proteomics Vol.16 No.7
<P>Sorafenib is the only standard treatment for unresectable hepatocellular carcinoma (HCC), but it provides modest survival benefits over placebo, necessitating predictive biomarkers of the response to sorafenib. Serum samples were obtained from 115 consecutive patients with HCC before sorafenib treatment and analyzed by multiple reaction monitoring-mass spectrometry (MRM-MS) and ELISA to quantify candidate biomarkers. We verified a triple-marker panel to be predictive of the response to sorafenib by MRM-MS, comprising CD5 antigen-like (CD5L), immunoglobulin J (IGJ), and galectin-3-binding protein (LGALS3BP), in HCC patients. This panel was a significant predictor (AUROC > 0.950) of the response to sorafenib treatment, having the best cut-off value (0.4) by multivariate analysis. In the training set, patients who exceeded this cut-off value had significantly better overall survival (median, 21.4 months) than those with lower values (median, 8.6 months; p = 0.001). Further, a value that was lower than this cutoff was an independent predictor of poor overall survival [hazard ratio (HR), 2.728; 95% confidence interval (CI), 1.312-5.672; p = 0.007] and remained an independent predictive factor of rapid progression (HR, 2.631; 95% CI, 1.448-4.780; p = 0.002). When applied to the independent validation set, levels of the cut-off value for triple-marker panel maintained their prognostic value for poor clinical outcomes. On the contrast, the triple-marker panel was not a prognostic factor for patients who were treated with transarterial chemoembolization (TACE). The discriminatory signature of a triple-marker panel provides new insights into targeted proteomic biomarkers for individualized sorafenib therapy.</P>
Injun Jeon,Jin Hyun Hwang,Tae Gyun Kim,Linghong Yin,이형우,Jong Pil Kim,Hyung Soo Ahn,조채용 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.2
Peony flower-like γ-Ga2O3 nanosheets (γ-Ga2O3 NSs) were synthesized and carbon layers were coated on their surfaces usinga simple hydrothermal process with subsequent carbonization. The γ-Ga2O3 NSs comprised ultrathin layers, which are tensof nanometers in thickness. The carbon-coated γ-Ga2O3 NS (γ-Ga2O3@C NS) electrode exhibited a specific capacity of 598mAh g−1 at 200 cycles, at a current density of 0.5 A g−1, higher than that of γ-Ga2O3 NSs (60 mAh g−1). Furthermore, a specificcapacity of 100 mAh g−1 at 5 A g−1 was achieved owing to the low charge transfer resistance through the carbon layers. Thisstudy suggests that two-dimensional γ-Ga2O3@C NSs with both large specific area and high charge carrier transport arepromising active materials for lithium-ion battery anodes with better electrochemical performance.
Characteristics of Copper Microspheres Grown by Using Mixed-Source Hydride Vapor-Phase Epitaxy
KIM, Kyoung Hwa,AHN, Ji-Hoon,AHN*, Hyung Soo,YANG, Min,YI, Sam Nyung,JEON, Injun,CHO, Chae Ryong,JEON, Hunsoo,LEE, Jae Hak,LEE, Hyo Suk,KIM*, Suck-Whan Korean Physical Society 2018 New Physics: Sae Mulli Vol.68 No.10
Growth of a Thick AlN Epilayer by Using the Mixed-Source Hydride Vapor Phase Epitaxy Method
Kim Kyoung Hwa,Park Jung Hyun,Ahn Hyung Soo,Yang Min,Yi Sam Nyung,Jeon Injun,Cho Chae Ryong,Kim Suck-Whan 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.4
A thick AlN epilayer with an approximately 1.25-mm thickness was grown on a sapphire substrate by using a mixed source (Al+Ga of very small amount) at around 1150 °C for 2 hours and a mixed-source hydride vapor phase epitaxy (HVPE) method in a simplified reactor interlinked in series with no separation between the source and the growth zones. The simplified reactor was designed to minimize the reaction between quartz and AlCl vapor species of a high partial pressure at around 1150 °C. The growth of the thick AlN epilayer seemed to be due to the very high growth rate (maximum value of 600 μm/h) resulting from the minimization of the response distance between the vapor species and the source gases caused by interlinking in series the edge of the source zone with the substrate in the growth zone. The characteristics of the grown thick AlN epilayer were investigated by using cross-sectional scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), Raman spectrometry and X-ray diffraction (XRD).
Effect of Skin Lipid Barrier Formation on Hataedock Treatment with Douchi
Kim, Hee-Yeon,Ahn, Sang-hyun,Yang, Injun,Kim, Kibong The Society of Korean Medicine 2017 대한한의학회지 Vol.38 No.2
Objectives: Hataedock is indigenous treatment of Korean medicine that administers herbal extracts orally to newborn infants for remove the fetal heat. The purpose of this study was to evaluate skin lipid barrier formation effect of Hataedock treatment with Douchi. Methods: We measured the Western blot to observe the expression of protein such as involucrin and loricrin. Moreover, we observed immunohistochemical changes in NC/Nga mice. The 3-week-old NC/Nga mice were divided into 3 groups: the 3-week-old control group (3w-Ctrl), 5-week-old control group (5w-Ctrl), and the Hataedock-treated group (5w-FGT). Only the 5w-FGT group was treated with Douchi at the 3rd week. We identified the changes of the lipid skin barrier and protein differentiation through immunohistochemical changes of involucrin, loricrin, filaggrin and acid sphingomyelinase (ASM) in the stratum corneum. Results: The expression of involucrin and loricrin was increased in the Western blot that was treated with concentration of Douchi extracts. In 5w-FGT group, loricrin-positive reaction was increased by 54.0%, involucrin-positive reaction was increased by 84.0%, filaggrin-positive reaction was increased by 108.0% and ASM-positive reaction was increased by 91.0% in the stratum corneum. Conclusions: These results suggest that Hataedock treatment with Douchi promoted skin lipid barrier formation by promoting differentiation of keratinocytes.