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김인겸 聖潔大學校 情報産業技術硏究所 1999 情報産業技術論叢 Vol.4 No.-
In this paper, it is presented the characteristics of the signal fading in three propagation environment. At first, the fading of a propagation signal is experimented in LOS(Line of Sight) regions without any obstacle. In the second, the signal fading is experimented in residential regions which have various houses and apartments. Finally signal fading is measured in the center of the city that have various markets, offices, and buildings. The fading of measured signals is very compatible in the existent propagation models. Especially the doppler effect is verified in the LOS region. The large scale fading and small scale fading are verified in the experimented data in the high frequency propagation environment for IMT-2000.
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김인겸 聖潔大學校 情報産業技術硏究所 1998 情報産業技術論叢 Vol.3 No.-
In this thesis, a new convex set based on POCS theory is proposed employing an edge-block-smoothing convex set for efficient processing of blocks having diagonal edge. The proposed method is aimed at removing blocking artifact in very low bit-rate coding. First, edge detection is performed on the block. The block is classified according to the direction of the edge within the block as vertical-edge block, horizontal-edge block, or diagonal-edge block. For diagonal-edge block, a blurring process is performed in the direction of the edge to remove blocking artifacts along the edge. The conventional methods do not consider the direction of the edge and the blocking artifacts are not effectively removed for diagonal edge. Experimental results show that the performance of the proposed method is superior to that of conventional method by retaining the high frequency elements while removing blocking artifacts especially for diagonal-edge block. The proposed method can be applied to the post processing of the block-based image coding.
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Mina Kim,Inkyeom Kim 대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.1
High fructose diet is associated with the global metabolic syndrome (MtS) pandemic. MtS develops in early life, depending on prenatal and postnatal nutritional status. We hypothesized that ovariectomy increases the chances of developing MtS in adult offspring following high fructose intake by the mother. Pregnant C57BL/6J mouse dams drank water with or without 20% fructose during pregnancy and lactation. After weaning, the pups were fed regular chow. The offspring were evaluated until they were 7 months of age after the mice in each group, both sexes, were gonadectomized at 4 weeks of age. The offspring (both sexes) of the dams who had high fructose intake developed MtS. In the offspring of dams who drank tap water, orchiectomy increased the body weight gain and body fat accumulation, while ovariectomy increased the body fat accumulation as compared to the sham controls. In the offspring of dams with high fructose intake, orchiectomy decreased the body weight gain, body fat accumulation, visceral adiposity, and glucose intolerance, while ovariectomy exacerbated all of them as compared to the sham operations. These data indicate that ovariectomy encourages the development of MtS in adult offspring after maternal high fructose intake, while orchiectomy prevents the development of MtS. The sex difference indicates that male and female sex hormones play contradictory roles in the development of MtS.
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Pulse Exposure to Ethanol Augments Vascular Contractility Through Stress Response
Eun-Kyoung Yang,InKyeom Kim 대한생리학회-대한약리학회 2001 The Korean Journal of Physiology & Pharmacology Vol.5 No.1
<P> Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as a stress factor on vasculature and indirectly modulates vascular contractility. After end of exposure to 1, 2.5 and 5% ethanol for 45 min, rat aortic strips were subjected to contractile responses, immunoblot for Hsp70 and the measurement of levels of myosin light chain phosphorylation. Exposure to 5% ethanol not only augmented contractions to KCl or phenylephrine, but also increased expression of Hsp70 and the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by 1μmol/L phorbol 12,13-dibutyrate, a protein kinase C activator, whether the tissues were exposed to 5% ethanol or not. This is the first report to show that even short exposure to ethanol has a delayed effect to increase vascular smooth muscle contractility through a modulation of thick filament regulation. It may be a mechanism by which ingestion of alcohol induces hypertension.
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정연식(Yeonsik Jeong),김인겸(Inkyeom Kim) 한국정보과학회 2003 정보과학회 컴퓨팅의 실제 논문지 Vol.9 No.4
본 논문에서는 공개키 기반구조에 기반한 통합 인증 시스템을 설계, 구현하였다. 통합 인증 시스템에서는 사용자가 하나의 패스워드를 이용해서 분산 컴퓨팅 환경하의 모든 응용 서버에 접속할 수 있으며, 사용자가 입력한 패스워드가 네트워크를 통해서 전송되지 않으므로 패스워드 도청 및 재사용 공격으로부터 안전하다. 제안한 시스템은 전자서명과 암호학적 인증 프로토콜을 이용하여 구현되었으며, 안정적인 시스템 설계를 위하여 메시지 시퀀스 차트와 상태 천이 다이어그램을 이용하였다. In this paper, a single sign-on system has been designed and implemented. The purpose of the proposed system is that a user logs in once using a single password and gets authenticated access to all the servers that he is authorized to use without sending any passwords over the network. The proposed system involves the use of digital signature and cryptographic authentication protocols. For its implementation, a public-key infrastructure is also designed and implemented. To view the behavior of the proposed system, message sequence charts and state transition diagrams have been presented.
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Soohyeon Koo,Mina Kim,Hyun Min Cho,Inkyeom Kim 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.2
BACKGROUND/OBJECTIVES: Nutritional status and food intake during pregnancy and lactation can affect fetal programming. In the current metabolic syndrome epidemic, highfructose diets have been strongly implicated. This study investigated the effect of maternal high-fructose intake during pregnancy and lactation on the development of metabolic syndrome in adult offspring. SUBJECTS/METHODS: Drinking water with or without 20% fructose was administered to female C57BL/6J mice over the course of their pregnancy and lactation periods. After weaning, pups ate regular chow. Accu-Chek Performa was used to measure glucose levels, and a tail-cuff method was used to examine systolic blood pressure. Animals were sacrificed at 7 months, their livers were excised, and sections were stained with Oil Red O and hematoxylin and eosin (H&E) staining. Kidneys were collected for gene expression analysis using quantitative real-time Polymerase chain reaction. RESULTS: Adult offspring exposed to maternal high-fructose intake during pregnancy and lactation presented with heavier body weights, fattier livers, and broader areas under the curve in glucose tolerance test values than control offspring. Serum levels of alanine aminotransferase, aspartate aminotransferase, glucose, triglycerides, and total cholesterol and systolic blood pressure in the maternal high-fructose group were higher than that in controls. However, there were no significant differences in mRNA expressions of renin-angiotensin-aldosterone system genes and sodium transporter genes. CONCLUSIONS: These results suggest that maternal high-fructose intake during pregnancy and lactation induces metabolic syndrome with hyperglycemia, hypertension, and dyslipidemia in adult offspring.
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Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome
Mina Kim,Ga Young Do,Inkyeom Kim 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.4
High fructose intake induces hyperglycemia and hypertension. However, the mechanism by which fructose induces metabolic syndrome is largely unknown. We hypothesized that high fructose intake induces activation of the renin-angiotensin system (RAS), resulting in hypertension and metabolic syndrome. We provided 11-week-old Sprague-Dawley rats with drinking water, with or without 20% fructose, for two weeks. We measured serum renin, angiotensin II (Ang II), and aldosterone (Aldo) using ELISA kits. The expression of RAS genes was determined by quantitative reverse transcription polymerase chain reaction. High fructose intake increased body weight and water retention, regardless of food intake or urine volume. After two weeks, fructose intake induced glucose intolerance and hypertension. High fructose intake increased serum renin, Ang II, triglyceride, and cholesterol levels, but not Aldo levels. High fructose intake increased the expression of angiotensinogen in the liver; angiotensin-converting enzyme in the lungs; and renin, angiotensin II type 1a receptor (AT1aR), and angiotensin II type 1b receptor (AT1bR) in the kidneys. However, expression of AT1aR and AT1bR in the adrenal glands did not increase in rats given fructose. Taken together, these results indicate that high fructose intake induces activation of RAS, resulting in hypertension and metabolic syndrome.
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Cho, Hyun Min,Seok, Young Mi,Lee, Hae Ahm,Song, Minji,Kim, InKyeom MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.11
<P>Type 2 diabetes mellitus (T2DM) is a chronic disease manifested by hyperglycemia. It is essential to effectively control hyperglycemia to prevent complications of T2DM. Here, we hypothesize that repression of transcriptional activity of forkhead box O1 (FoxO1) via histone deacetylase inhibitors (HDACi) ameliorates hyperglycemia in T2DM rats. Methods: Male Long-Evans Tokushima Otsuka (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats aged 14 weeks were administered sodium valproate (VPA, 0.71% <I>w</I>/<I>v</I>) dissolved in water for 20 weeks. Electrophoretic mobility shift assay (EMSA) and luciferase assay were performed for elucidation of transcriptional regulation through acetylation of FoxO1 by HDACi. Results: VPA attenuated blood glucose levels in accordance with a decrease in the expression of gluconeogenic genes in hyperglycemic OLETF rats. It has been shown that HDAC class I-specific and HDAC class IIa-specific inhibitors, as well as pan-HDAC inhibitors decrease FoxO1 enrichment at the <I>cis</I>-element of target gene promoters. Mutations in FoxO1 prevent its acetylation, thereby increasing its transcriptional activity. HDAC3 and HDAC4 interact with FoxO1, and knockdown of HDAC3, HDAC4, or their combination increases FoxO1 acetylation, thereby decreasing the expression of gluconeogenic genes. Conclusions: These results indicate that HDACi attenuates the transcriptional activity of FoxO1 by impeding deacetylation, thereby ameliorating hyperglycemia in T2DM rats.</P>
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