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Bhat, Imtiyaz Ahmad,Pandith, Arshid A.,Bhat, Bashir A.,Naykoo, Niyaz A.,Qasim, Iqbal,Rasool, Roohi,Aziz, Sheik Aejaz,Shah, Zafar Amin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Chronic inflammation is considered as an important factor in the pathogenesis of lung cancer. The presence of inflammatory cells and higher levels of pro-inflammatory cytokines in the tumor microenvironment and their surrounding tissues is gaining much importance in research. Materials and Methods: One hundred ninety NSCLC cases and 200 age, smoking and sex matched controls were evaluated for association of IL-8 -251 (rs4073) and IL-8 -845 (rs2227532) in our population. Restriction fragment length polymorphism (RFLP) was used followed by direct sequencing for the detection of SNPs. Results: The IL-8 -845 polymorphism was not found in our population. No significant association was observed between the IL-8 -251 AT genotypes and IL-8 -25 AA genotypes and NSCLC (p=0.05) in our population. The IL-8 -251 A allele was also non-significant (p=0.05) in NSCLC patients. Conclusions: In conclusion, this report reveals lack of association between IL-8 - 251 A/T polymorphism and NSCLC in our Kashmir Valley population.
Bhat, Imtiyaz Ahmad,Devaraj, Anthonisamy,Howlader, Prodip,Chi, Ki-Whan,Mukherjee, Partha Sarathi The Royal Society of Chemistry 2018 Chemical communications Vol.54 No.38
<P>The reaction of chiral <I>cis</I>-[(1<I>S</I>,2<I>S</I>)-<I>dch</I>]Pt(NO3)2 (M) [where (1<I>S</I>,2<I>S</I>)-<I>dch =</I> (1<I>S</I>,2<I>S</I>)-1,2-diaminocyclohexane] with a hexadentate ligand (L) in 3 : 1 stoichiometric ratio yielded a [12+4] self-assembled chiral M12L4 molecular tetrahedron (T). The cage T features an internal 3D nanocavity with large open ‘windows’, enabling it to catalyze Michael addition reactions of a series of nitrostyrene derivatives with indole in a 9 : 1 water : methanol mixture.</P>
Imtiyaz Ahmad Bhat,Bibhisan Roy,Kabir-ud-Din 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.63 No.-
Compilation of novel surfactant–protein mixtures has always been an intriguing and fascinating domain owing to their implications in industrial and cosmetic realms. In this regard, herein; we have synthesized a new cleavable gemini surfactant and investigated its influence on the structural characteristics of lysozyme via state-of-art techniques. Results have demonstrated the complex formation, unfolding and stabilization of lysozyme upon gemini surfactant combination. Docking/DFT has shown that gemini binds in the vicinity of hydrophobic residues (Trp/Tyr) and interacts via both electrostatic and hydrophobic contributions. This study may be significant to devise novel surfactant–protein mixtures for their end use at industrial stratum.
Imtiyaz Ahmad Bhat,Bibhisan Roy,Kabir-ud-Din 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-
In this communication we have observed that cleavable gemini surfactant micelles inducefluorescenceswitching in novel probe (bound to lysozyme) at lower concentrations ( 2.63 mM) compared toconventional surfactants, which are known to induce such phenomenon at above 30 mM. Fluorescenceswitching being important in sensing, binding, and probing the conformational states of proteins;therefore, in future this study could be significant to protein analytics and other relevant industrialdomains.
Qasim, Iqbal,Bhat, Imtiyaz Ahmad,Masoodi, Khalid Zafar,Shah, Zafar Amin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: The gene for the vascular endothelial growth factor (VEGF), which promotes angiogenesis and permeability, is polymorphic. The aim of the present study was to evaluate the relationship between +936C>T and +404C>G polymorphism of VEGF with risk of esophageal cancer in the Kashmiri population in India. Materials and Methods: 150 esophageal cancer patients and 150 unrelated healthy controls were genotyped for two VGEF SNPs (+405C/G, and +936C/T) using DNA extracted from prospectively collected blood samples by the PCR-RFLP method. Results: For the VEGF +936C>T polymorphism a significant association of CT and combined CT+TT genotypes was observed with increased risk of esophageal cancer (p=0.021; 0.024). For the +405C>G polymorphism we observed significantly increased frequency of GG genotype in cases as compared to controls and also the +405 GG Genotype was observed to have a two fold risk(OR=2.7356; 95%CI=1.1409-6.5593; p=0.020). The combined genotypes of GG-CC and GG-CT of +405C>G and +936C>T were found to be significantly associated with increased risk of esophageal cancer (p=0.0376; 0.0099). Conclusions: From the results of the present study a significant association of +936C>T and +405C>G polymorphisms with increased esophageal cancer risk exists in the Kashmiri population.
Mohd. Akram,Imtiyaz Ahmad Bhat,Abiyu Kerebo Berekute,Kabir-ud-Din 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.40 No.-
Herein, we have investigated the effect of inorganic and organic salts (NaCl, Na2SO4, Na3PO4, NaAn andNaTos) on the solution behaviour of a gemini surfactant, ethane-1,2-diyl bis(N,N-dimethyl-N-dodecylam-moniumacetoxy) dichloride (12-E2-12), employing surface tensiometry, fluorescence, 1H NMR, TEM, UV–vis, and FT-IR. The surface tension measurements showed that all micellization characteristics were refinedin the presence of salts with the order being NaAn > NaTos > Na3PO4 > Na2SO4 > NaCl. Whereasfluorescence measurements were used to estimate the aggregation number (Nagg) of the micelles. 1HNMR, TEM, UV–vis, and FT-IR results revealed morphological transition and newer phase formation. Thisstudy in future could be useful for compilation of surfactant–salt mixtures for industrial applications.
Jeenat Aslam,Umme Salma Siddiqui,Imtiyaz Ahmad Bhat,Kabir-ud-Din 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
In the present study, mixtures of cationic gemini surfactants with a non-ionic sugar-based surfactant in aqueous solutions containing electrolyte (NaBr) have been studied. The experimental results were evaluated using the Regular Solution Theory. The strength of interaction of all the surfactants is attributed to the sterical and electrical factors on mixed monolayer and micelle formation and of surfactant–surfactant interactions. The results show stronger interaction at the air/water interface and greater preference for adsorbing at the air/water interface relative to mixed micelle formation in the solution phase. The alkyl chain length and spacer of gemini govern the aggregation behavior of the mixed micelles.
The XRCC1 Arg399Gln Gene Polymorphism and Risk of Colorectal Cancer: a Study in Kashmir
Khan, Nighat Parveen,Pandith, Arshad Ahmad,Yousuf, Adfar,Khan, Nuzhat Shaheen,Khan, Mosin Saleem,Bhat, Imtiyaz Ahmad,Nazir, Zahoor Wani,Wani, Khursheed Alam,Hussain, Mahboob Ul,Mudassar, Syed Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: The DNA repair gene XRCC1 Arg399Gln gene polymorphism has been found to be implicated in the development of various cancers, including colorectal cancer (CRC), in different populations. We aimed to determine any association of this polymorphism with the risk of CRC in Kashmir. Materials and Methods: A total of 120 confirmed cases of CRC and 146 healthy cancer free controls from the Kashmiri population were included in this study. Genotyping was carried out by the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Results: Genotype frequencies of XRCC1 Arg399Gln observed in controls were 34.2%, 42.5% and 23.3% for GG (Arg/Arg), GA (Arg/Gln), AA( Gln/Gln), respectively, and 28.3%, 66.7% and 5% in cases, with an odds ratio (OR)=5.7 and 95% confidence interval (CI) =2.3-14.1 (p=0.0001). No significant association of Arg399Gln SNP with any clinicopathological parameters of CRC was found. Conclusions: We found the protective role of 399Gln allele against risk to the development of CRC. The XRCC1 heterozygote status appears to be a strong risk factor for CRC development in the Kashmiri population.