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Sung Ho Lee,Tae-Hoon Kim,Yong-Seog Oh,Seil Oh,Jong-Il Choi,Jin-Bae Kim,Jong-Chun Nah,Sung Il Im,Ki-Woon Kang,Seongwook Han,June Soo Kim 대한의학회 2020 Journal of Korean medical science Vol.35 No.2
Background: An implantable loop recorder (ILR) is an effective tool for diagnosing unexplained syncope (US). We examined the diagnostic utility of an ILR in detecting arrhythmic causes of US and determining which clinical factors are associated with pacemaker (PM) implantation. Methods: This retrospective, multicenter, observational study was conducted from February 2006 to April 2018 at 11 hospitals in Korea. Eligible patients with recurrent US received an ILR to diagnose recurrent syncope and document arrhythmia. Results: A total of 173 US patients (mean age, 67.6 ± 16.5 years; 107 men [61.8%]) who received an ILR after a negative conventional workup were enrolled. During a mean follow-up of 9.4 ± 11.1 months, 52 patients (30.1%) had recurrent syncope, and syncope- correlated arrhythmia was confirmed in 34 patients (19.7%). The ILR analysis showed sinus node dysfunction in 24 patients (70.6%), supraventricular tachyarrhythmia in 4 (11.8%), ventricular arrhythmia in 4 (11.8%), and sudden atrioventricular block in 2 (5.9%). Overall, ILR detected significant arrhythmia in 99 patients (57.2%) irrespective of syncope. Among patients with clinically relevant arrhythmia detected by ILR, PM implantation was performed in 60 (34.7%), an intra-cardiac defibrillator in 5 (2.9%), and catheter ablation in 4 (2.3%). In a Cox regression analysis, history of paroxysmal atrial fibrillation (PAF) (hazard ratio [HR], 2.34; 95% confidence interval [CI], 1.33–4.12; P < 0.01) and any bundle branch block (BBB) (HR, 2.52; 95% CI, 1.09–5.85; P = 0.03) were significantly associated with PM implantation. Conclusion: ILR is useful for detecting syncope-correlated arrhythmia in patients with US. The risk of PM is high in US patients with a history of PAF and any BBB.
Effects of proton beam irradiation on seed germination and growth of soybean (Glycine max L. Merr.)
Im, Juhyun,Kim, Woon Ji,Kim, Sang Hun,Ha, Bo-Keun 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>The present study aimed to evaluate the morphological effects of proton beam irradiation on the seed germination, seedling survival, and plant growth of soybean. Seeds of three Korean elite cultivars (Kwangankong, Daepungkong, and Pungsannamulkong) were irradiated with a 57-MeV proton beam in the range of 50 - 400 Gy. The germination rates of all the varieties increased to > 95%; however, the survival rates were significantly reduced. At doses of > 300 Gy irradiation, the Daepungkong, Kwangankong, and Pungsannamulkong cultivars exhibited 39, 75, and 71% survival rates, respectively. In addition, plant height and the fresh weight of shoots and roots were significantly decreased by doses of > 100 Gy irradiation, as were the dry weights of the shoots and roots. However, SPAD values increased with increasing doses of irradiation. Abnormal plants with atypically branched stems, modified leaves, and chlorophyll mutations were observed. Based on the survival rate, plant growth inhibition, and mutation frequency, it appears that the optimum dosage of proton beam irradiation for soybean mutation breeding is between 250 and 300 Gy.</P>
클로람페니콜 내성 플라스미드 pKH7의 Rep 단백질과 CAT 단백질의 염기서열 분석
윤성준(Sung Joon Yoon),이대운(Dae Woon Lee),김우구(Woo Koo Kim),신철교(Chul Kyo Shin),임성환(Sung Hwan Im),문경호(Kyung Ho Moon) 대한약학회 1995 약학회지 Vol.39 No.6
The nucleotide sequence of XbaI-MboI fragment of pKH7, a chloramphenicol-resistant(Cmr) plasmid isolated from multidrug-resistant S. aureus SA2, has been determined. XbaI-MboI fragment of pKH7 was found to contain two ORFs. One ORF encoded Rep and the other encoded CAT protein. The deduced amino acid sequences of Rep and CAT of pKH7 were compared to those of pUB112 and pC221. Comparisons revealed that there was one amino acid dfference in CAT between pKH7 and pUB112. CAT of pKH7 exhibited 98.6% amino acid identity to that of pC221. In case of Rep proteins, a slightly lower homology of 96.4% and 86.7% in amino acid sequences was observed betweeen pKH7 and pUB112 and between pKH7 and pC221, respectively.
Lee, Sang-Hak,Cho, Kyoung-Im,Kim, Jang-Young,Ahn, Young Keun,Rha, Seung-Woon,Kim, Yong-Jin,Choi, Yun-Seok,Choi, Si Wan,Jeon, Dong Woon,Min, Pil-Ki,Choi, Dong-Ju,Baek, Sang Hong,Kim, Kwon Sam,Byun, You Elsevier 2012 Atherosclerosis Vol.221 No.1
<P><B>Highlights</B></P><P>► Rosuvastatin–fenofibrate combination and rosuvastatin monotherapy were compared. ► We randomized 180 Asians with mixed hyperlipidemia with 24-week drug treatment. ► Incidences of muscle or liver enzyme elevation were similar between the two groups. ► The combination changed homocysteine, renal and hematologic parameters more.</P> <P><B>Abstract</B></P><P><B>Objective</B></P><P>The aim of this study is to compare the non-lipid effects of rosuvastatin–fenofibrate combination therapy with rosuvastatin monotherapy in high-risk Asian patients with mixed hyperlipidemia.</P><P><B>Methods</B></P><P>A total of 236 patients were initially screened. After six weeks of diet and life style changes, 180 of these patients were randomly assigned to receive one of two regimens: rosuvastatin 10mg plus fenofibrate 160mg or rosuvastatin 10mg. The primary outcome variables were the incidences of muscle or liver enzyme elevation. The patients were followed for 24 weeks during drug treatment and for an additional four weeks after drug discontinuation.</P><P><B>Results</B></P><P>The rates of the primary outcome variables were similar between the two groups (2.8% and 3.9% in the combination and the rosuvastatin groups, respectively, <I>p</I>=1.00). The combination group had more, but not significantly, common treatment-related adverse events (AEs) (13.3% and 5.6%, respectively) and drug discontinuation due to AEs (10.0% and 3.3%, respectively) than the rosouvastatin group. Combination therapy was associated with higher elevations in homocysteine, blood urea nitrogen, and serum creatinine, whereas elevation in alanine aminotransferase was greater in the rosuvastatin group. Leukocyte count and hemoglobin level decreased to a greater extent in the combination group. The combination group showed greater reductions in TG and elevation in HDL-cholesterol.</P><P><B>Conclusion</B></P><P>In our study population, the rosuvastatin–fenofibrate combination resulted in comparable incidences of myo- or hepatotoxicity as rosuvastatin monotherapy. However, this combination may need to be used with caution in individuals with underlying pathologies such as renal dysfunction (NCT01414803).</P>
( Juhyun Im ),( Jaihyunk Ryu ),( Woon Ji Kim ),( Sang Hun Kim ),( Si-yong Kang ),( Bo-keun Ha ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.2
The present study was conducted to evaluate the biological responses of soybean irradiated by gamma-rays. Four elite Korean soybean cultivars, Kwangankong, Shinpaldal-2, Shinhwakong, and Ilmikong, were irradiated with 100-400 Gy of gamma-rays. All cultivars showed significant reductions in morphological parameters. Seedling emergence rates of Kwangankong, Shinpaldal-2, Shinhwakong, and Ilmikong decreased by 46%, 31%, 44%, and 43% at 400 Gy, respectively. Plant height and fresh weight decreased with increasing dose. The median reduction dose (RD50) for plant height ranged from 184 to 278 Gy with an average of 212 Gy.The optimal dose of gamma irradiation for inducing mutation in the four elite soybean cultivars was in the range 200-300 Gy. Contents of malonaldehyde (MDA) in the gamma-ray irradiated plants were higher than those in the controls. With the exception of Kwangankong, activities of ascorbate peroxidase (APX) in other cultivars decreased at 100 Gy and started to increase significantly at 200 Gy and Shinhwakong cultivar had highest APX value observed at 300 Gy. No significant changes in peroxidase (POD) activity were observed inthe Kwangankong, Shinpaldal-2, and Shinhwakong, while, POD activity increased with increasing dose in Ilmikong. In addition, gamma-ray treatments elicited a marked reduction in chlorophyll a contents compared to chlorophyll b contents in Kwangankong, Shinpaldal-2, and Ilmikong. Growth characteristics (plant height and fresh weight) were highly negatively (P < 0.01) correlated with the dose of gamma-rays, while the MDA content and APX activities were positively (P < 0.05) correlated with dose.