Scoparone from Artemisia capillaris Inhibits the Release of Inflammatory Mediators in RAW 264.7 Cells upon Stimulation Cells by Interferon-γ Plus LPS

Seon Il Jang,Young-Jun Kim,Woo-Yiel Lee,Kyung Chell Kwak,Seung Hwa Baek,Gyu Beum Kwak,Young-Gab Yun,Tae-Oh Kwon,Hun Taeg Chung,Kyu-Yun Chai 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.2

Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) upon stimulation by IFN-γ/LPS or LPS. The inhibitory effects were found to be in conjuction with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in IFN-γ/LPS stimulated RAW 264.7 cells. Moreover, scoparone also attenuated the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 in LPS-stimulated RAW264.7 cells. These results suggest that scoparone decreases the production of the inflammatory mediators such as NO and PGE2 in macrophages by inhibiting iNOS and COX-2 expression.

Scoparone from Artemisia capillaris Inhibits the Release of Inflammatory Mediators in RAW 264.7 Cells upon Stimulation Cells by Interferon-${\gamma}$ Plus LPS

Jang Seon Il,Kim Young-Jun,Lee Woo-Yiel,Kwak Kyung Chell,Baek Seung Hwa,Kwak Gyu Beum,Yun Young-Gab,Kwon Tae-Oh,Chung Hun Taeg,Chai Kyu-Yun The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.2

Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ upon stimulation by IFN-${\gamma}$/LPS or LPS. The inhibitory effects were found to be in conjuction with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in IFN-${\gamma}$/LPS stimulated RAW 264.7 cells. Moreover, scoparone also attenuated the production of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-6 in LPS-stimulated RAW264.7 cells. These results suggest that scoparone decreases the production of the inflammatory mediators such as NO and $PGE_2$ in macrophages by inhibiting iNOS and COX-2 expression.

The effects of BRL-50481 on ovalbumin-induced asthmatic lung infl ammation exacerbated by co-exposure to Asian sand dust in the murine model

Hong Jo Kim,Jin Yong Song,Tae Il Park,Won Seok Choi,Jong Heon Kim,Oh Seong Kwon,Ji-Yun Lee 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.1

Asian sand dust (ASD), which mainly originatesin China and Mongolia in the spring and blows into Korea,can exacerbate respiratory and immunological diseases. This study aims to observe eff ects of co-exposure to ASD onovalbumin (OVA)-induced asthmatic lung infl ammation andof treatment with a phosphodiesterase 7 (PDE7) inhibitor ina mouse model. The challenge with OVA increased airwayhyperresponsiveness (AHR) and infl ammatory cell infi ltrationinto the lung tissue. Interleukin (IL)-13, tumor necrosisfactor-alpha, monocyte-protein-1, mucin, and antigen-specific IgE and IgG1 production increased in mouse serum. The co-exposure of ASD signifi cantly exacerbated theseeff ects in this asthma model. Notably, the administration ofa PDE7 inhibitor, BRL-50481 (BRL), signifi cantly reducedAHR, infi ltration of infl ammatory cells into the lungs, andthe levels of type 2 T helper cell-related cytokines, antigenspecific immunoglobulins, and mucin. Thus, the administrationof BRL ameliorated OVA-induced allergic asthmaticresponses exacerbated by co-exposure to ASD. This studysuggests that PDE7 inhibition can be a therapeutic strategyfor infl ammatory lung diseases and asthma via the regulation of T lymphocytes and reduction of IL-13, and, consequently,mucin production.

A soft biomolecule actuator based on a highly functionalized bacterial cellulose nano-fiber network with carboxylic acid groups

Wang, Fan,Jeon, Jin-Han,Park, Sukho,Kee, Chang-Doo,Kim, Seong-Jun,Oh, Il-Kwon The Royal Society of Chemistry 2016 SOFT MATTER Vol.12 No.1

<P>Upcoming human-related applications such as soft wearable electronics, flexible haptic systems, and active bio-medical devices will require bio-friendly actuating materials. Here, we report a soft biomolecule actuator based on carboxylated bacterial cellulose (CBC), ionic liquid (IL), and poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) electrodes. Soft and biocompatible polymer-IL composites were prepared via doping of CBC with ILs. The highly conductive PEDOT: PSS layers were deposited on both sides of the CBC-IL membranes by a dip-coating technique to yield a sandwiched actuator system. Ionic conductivity and ionic exchange capacity of the CBC membrane can be increased up to 22.8 times and 1.5 times compared with pristine bacterial cellulose (BC), respectively, resulting in 8 times large bending deformation than the pure BC actuators with metallic electrodes in an open air environment. The developed CBC-IL actuators show significant progress in the development of biocompatible and soft actuating materials with quick response, low operating voltage and comparatively large bending deformation.</P>

원격조작에 의한 작업대상물 강성과 마찰 특성의 동정

권혁조,전지명,김진옥,문일동,오재윤 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

This study performs a workpiece stiffness and frictional characteristic identification experiments by teleoperation. Experiments are performed using a bilateral force feedback teleoperation system. It is composed of a master manipulator, the slave manipulator equipped with a force/torque sensor, and a real-time control system. To control the teleoperation system, a position-force controller is developed. The slave manipulator is controlled by the master manipulator's position command and the master manipulator is controlled by the force information from the slave manipulator. This study presents a method to find the slave manipulator's stiffness. And, this study presents a method to compute the workpiece stiffness based on the measured pressing force and deflection at the slave manipulator. Also, this study performs a workpiece frictional characteristic identification experiments. In the experiments, the slave manipulator rubs a workpiece with an arbitrary pressing force. While the slave manipulator rubs a workpiece, a vertical force and a frictional force are measured and the ratio of a frictional force to a vertical force is considered as a frictional characteristic.

청소년의 방과후 활동실태에 관한 연구

오치선,권일남 명지대학교 리서치아카데미 1999 리서치 아카데미 논총 Vol.2 No.-

본 연구는 초·중·고교생의 생활실태와 학교교육 만족도, 생활시간과 유형, 방과후 활동에 대한 관련사항을 분석하고 또한 이들의 생활여건을 개선하기 위한 내용을 종합적으로 분석하여 방과후 생활활동의 활성화방안을 마련함에 있다. 청소년의 방과후 생활상황에 대한 의식과 태도에 대한 설문문항을 작성하여 약 1,000명을 선정하여 설문조사를 실시하였다. 연구결과는 다음과 같다. 전반적으로 학교의 수업과 관련된 보충적인 과외활동은 그다지 심각한 상태는 아니었지만 학교교육에 대한 만족도는 그다지 높지 않음을 알 수 있었다. 학교생활의 불만원인은 주로 생활의 따분함과 단조로움으로 다양한 학습기회의 제공과 여건의 활성화가 필요한 것으로 보인다. 그리고 청소년의 여가유형은 주로 소극적 활동이 많았으며 많은 청소년들이 방과후 활동의 필요성을 인지하고 있는 것으로 나타났다. 따라서 방과후 활동 활성화를 위해서는 다음과 같이 노력이 필요할 것으로 보인다. 첫째, 학생들의 방과후 활동 시설의 확충과 다양한 프로그램의 개설이 매우 필요할 것으로 보인다. 둘째, 방과후 활동의 다양성을 확보하기 위한 지도자의 확보, 교사의 협력, 학교 및 정부의 적극적 관심이 뒤따라야 할 것으로 보인다. 셋째, 학교의 동아리활동을 활성화하여 방과후 활동이 학생문화를 창출하는 축제의 마당으로 자리잡도록 만들어주어야 할 것이다. The purpose of this study were 1) to analyze the school lifes and attitude of the students, 2) to search the problems related to life-style after class and 3) to suggest the desirable direction for the life-style activities after class for the youth. Data were collected drom 1,000 elementary, Junior and Senior high school student of the nation. The major fidings of this study were as follow; 1) The most youth were satisfied with their school life, extra-curricular activities, and achievement from their class. 2) Most youth reported that they gave the watching TV, a dilettante life like a passive activities after class. 3) The main problems of the after school activities are unpreparedness of programs and insuffcient public supports to youth facilities including financial difficulties. This future research should be focused on the program development and the expansion of youth activity facilities related to after-school activities in elementary and secondary school. It should also be focused on the development of the specific teaching stragies, insurance the teachers and leaders of youth activities, and integrated supports among the home, school and government.

후륜 에어 서스펜션을 장착한 대형상용차의 동특성 해석

문일동,오재윤,권혁조,이승호 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

This paper develops a computational model using ADAMS for dynamic characteristic analysis of a large-sized commercial vehicle with an air suspension system at rear axle. The air suspension system is composed of an air spring and a half-long tapered leaf spring. Its ADAMS model has 24 rigid bodies and 15 degree-of-freedom. For its modeling, 24 rigid bodies are connected by 10 cylindrical joints, 4 translational joints, 9 spherical joints, 2 universal joints, and 4 revolute joints. For the analysis of handling performance, a double lane change maneuver simulation is performed using the full vehicle ADAMS model with a trunnion suspension or air suspension at rear axle. The simulation is performed with a constant speed of 50, 60, and 70kph respectively. In the simulation, lateral acceleration, roll angle, and yaw rate at the mass center of frame and cab are measured for the handling analysis. For the analysis of ride performance, a bumpy ride simulation is performed using the model. The simulation is performed with a constant speed of 20kph. The bump used in the simulation has the height of 50, 80, and 100㎜ respectively. In the simulation, vertical displacement and pitch angle at the mass center of cab are measured for the ride performance analysis.

원공노치를 가진 CFRP의 적층방향에 따른 기계적 특성 평가

태영일,윤유성,권오헌 한국산업안전학회 2002 한국안전학회지 Vol.17 No.1

The tensile tests for [0/90]s, [90/0]s, and [0/±45/90]s laminate composite were accomplished with acoustic sensor and failure processes were recorded by a video camera in real time. Also SEM examinations for fracture and side surface were carried out. The purpose, of study is estimation of the failure mechanism and the mechanical properties effected by lay-up orientation for CFRP laminate composite with the hole notch. From the results, mechanical properties were obtained and they are similar between two kinds of cross-ply orientation in CFRP laminate composites, but not on [0/±45/90]s. And according to increasing the load, accumulate AE count was increased, regardless of lay-up orientation. Futhermore, failure mechanism was described by a video monitoring and SEM.

고등학생의 체육수업 참여태도와 정신 건강에 관한 연구

박순호,권오일 龍仁大學校 體育科學硏究所 2005 體育科學硏究論叢 Vol.15 No.1

The present study aims to reveal the effects of the high school students participation attitude and preference of physical on their mental health, for the purpose of helping them grow as sane and sound democratic citizens. A questionnaire method was used with 420 high schoolers in Kyoung ki do as the subjects. Based on the simple mental checkup test kit made in the Johns Hopkins Medical College and it's revised survey test (1984: Kim Gwang il, Kim, Jae Hwan & Won Ho taek) as well as a survey on physical education participation attitude (2000: Yi Jae yong), the researcher recomposed the questionnaire composed of 90 mental-health items and 21 class-participation questions. Through the reliability test, Cronbach's a was calculated. The Collected data were analyzed by the SPSS/PC+ (Version 12.0) program. Frequency analysis and multiple variable analysis were held to lead to the following results: The first, high school students were found to think high of physical education classes at school, particularly males were satisfied with the current physical education classes, 3 hours a week, but simply wanted to have more periods. The second, Girl students were significant in the symptoms of obsession and melancholy, the subsidiary of mental health. This was especially apparent in higher school years. In conclusion, the participation attitude of physical education surely had something to do with students mental health conditions. For instance, those students who were zealous in and satisfied with school sports classes had less symptoms of negative mental problems. Therefore, physical education teachers might have to devise diverse instruction methods to let the students join in the class aggressively as a way of helping them become whole and round people.

중량줄넘기 운동의 생리적 효과

전종귀,권오석,김일곤 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1

The purpose was to study the effects of weighted rope skipping training on the physiological factors. Fourteen untrained middle school boys were assigned into one of the two rope skipping groups: general rope(200g) skipping(GRS,N=7) and weighted rope(500g) skipping group(WRS,N=7).75.8 and 82.2%HRreserve were the training intensity of GRS and WRS,respectively.The rate, duration,and frequency of rope skipping were 1 tims/sec., 5 min./day,and 6 days/week, respectively.The cardiorespiratory responses to submaximal traemill running, anaerobic threshold,grip strength,and muscle power were measured before and after 6 weeks of the training period.Data were tested(p E, 02, CO2,R,and HR response to submaximal traedmill running after GRS and WRS training were decreased significantly.Grip strengrh was improved significantly with GRS and WRS training.But anaerobic threshold and muscle power were improved significantly with only WRS training.