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RISS 인기검색어
- 검색키워드
- 저자 : Idris Long (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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( Idris Long ),( Rapeah Suppian ),( Zalina Ismail ) 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.3
Background: We investigated the effects of pre-emptive administration of ketamine and norBNI on pain behavior and the expression of DREAM, c-Fos, and prodynorphin proteins on the ipsilateral side of the rat spinal cord at 2 and 4 hours after formalin injection. Methods: Eighty-four male Sprague Dawley rats were divided into 4 major groups consisting of control rats (C) (n = 12), rats given only formalin injections (F) (n = 24), and rats treated with pre-emptive administration of either ketamine (K+F) (n = 24) or norBNI (N+F) (n = 24). The non-control groups were further divided into subgroups consisting of rats that were sacrificed at 2 and 4 hours (n = 12 for each group) after formalin injection. Pain behavior was recorded for 1 hour. After 2 and 4 hours, the rats were sacrificed and the spinal cords (L4-L5 sections) were removed for immunohistochemistry and Western blot analysis. Results: The pain behavior response was reduced in the K+F group compared to the other groups during the second phase of the formalin pain response. We detected an increase in the nuclear DREAM protein level in the K+F group at 2 and 4 hours and a transient decrease in the N+F group at 2 hours; however, it increased at 4 hours after injection. Fos-like immunoreactivity (FLI) and Prodynorphin-like immunoreactivity (PLI) neurons decreased in the K+F group but increased in the N+F group at 2 hours after injection. While FLI decreased, PLI increased in all groups at 4 hours after injection. Conclusions: We suggest that NMDA and kappa opioid receptors can modulate DREAM protein expression, which can affect pain behavior and protein transcriptional processes at 2 hours and bring about either harmful or protective effects at 4 hours after formalin injection. (Korean J Pain 2013; 26: 255-264)
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Long, Idris,Suppian, Rapeah,Ismail, Zalina The Korean Pain Society 2013 The Korean Journal of Pain Vol.26 No.3
Background: We investigated the effects of pre-emptive administration of ketamine and norBNI on pain behavior and the expression of DREAM, c-Fos, and prodynorphin proteins on the ipsilateral side of the rat spinal cord at 2 and 4 hours after formalin injection. Methods: Eighty-four male Sprague Dawley rats were divided into 4 major groups consisting of control rats (C) (n = 12), rats given only formalin injections (F) (n = 24), and rats treated with pre-emptive administration of either ketamine (K+F) (n = 24) or norBNI (N+F) (n = 24). The non-control groups were further divided into subgroups consisting of rats that were sacrificed at 2 and 4 hours (n = 12 for each group) after formalin injection. Pain behavior was recorded for 1 hour. After 2 and 4 hours, the rats were sacrificed and the spinal cords (L4-L5 sections) were removed for immunohistochemistry and Western blot analysis. Results: The pain behavior response was reduced in the K+F group compared to the other groups during the second phase of the formalin pain response. We detected an increase in the nuclear DREAM protein level in the K+F group at 2 and 4 hours and a transient decrease in the N+F group at 2 hours; however, it increased at 4 hours after injection. Fos-like immunoreactivity (FLI) and Prodynorphin-like immunoreactivity (PLI) neurons decreased in the K+F group but increased in the N+F group at 2 hours after injection. While FLI decreased, PLI increased in all groups at 4 hours after injection. Conclusions: We suggest that NMDA and kappa opioid receptors can modulate DREAM protein expression, which can affect pain behavior and protein transcriptional processes at 2 hours and bring about either harmful or protective effects at 4 hours after formalin injection.
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Wan Yaacob Wan Muhammad Hilmi,Long Idris,Zakaria Rahimah,Othman Zahiruddin 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1
This study aims to evaluate the protective effects of Malaysian Tualang honey (TH) and its methanolic fraction (MTH) against oxidative stress, amyloid deposition and neuronal loss in the hippocampal tissue of lipopolysaccharide (LPS) rats. Sixty male Sprague Dawley rats were randomly divided into five groups: (1) control, (2) LPS (5 mg/kg), (3) LPS rats treated with 200 mg/kg TH, (4) LPS rats treated with 150 mg/kg MTH, and (5) LPS rats treated with 10 mg/kg memantine. The levels of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GPr), superoxide dismutase (SOD), malondialdehyde (MDA), and beta-amyloid (Aβ) in the hippocampal tissues were determined using ELISA method. The CAT and GPx levels were significantly higher in all the treatment groups compared to the LPS group. The levels of GR and SOD were found to be significantly higher in the TH and memantine groups, and TH group, respectively. The TH and MTH groups, but not memantine, significantly lower MDA level compared to the LPS group. TH and memantine attenuated the effect of LPS where the levels of Aβ1−40 were higher and Aβ1−42 were lower compared to the LPS group. MTH, however, failed to lower the level of Aβ1−42. The number of Nissl-positive neurons in all hippocampal regions was significantly lower in the LPS group compared to the control group. Both TH and MTH treatments significantly ameliorate LPS-induced neuronal loss comparable to memantine, suggesting their neuroprotective potential. TH, however, exhibits slightly higher neuroprotective potential against oxidative stress and amyloid deposition when compared to MTH.
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Che Aishah Nazariah Ismail,Rapeah Suppian,Che Badariah Abd Aziz,Khalilah Haris,Idris Long 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.2
Background: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. Methods: Thirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control, diabetes mellitus (DM) rats and diabetic rats treated with ifenprodil at a lower dose (0.5 μg/day) (I 0.5) or higher dose (1.0 μg/day) (I 1.0). DM was induced by a single injection of streptozotocin at 60 mg/kg on day 0 of experimentation. Diabetic status was assessed on day 3 of the experimentation. The responses on both tactile and thermal stimuli were assessed on day 0 (baseline), day 14 (pre-intervention), and day 22 (post-intervention). Ifenprodil was given intrathecally for 7 days from day 15 until day 21. On day 23, 5% formalin was injected into the rats’ hind paw and the nociceptive responses were recorded for 1 hour. The rats were sacrificed 72 hours postformalin injection and an analysis of the spinal NR2B expression was performed. Results: DM rats showed a significant reduction in pain threshold in response to the tactile and thermal stimuli and higher nociceptive response during the formalin test accompanied by the higher expression of phosphorylated spinal NR2B in both sides of the spinal cord. Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B. Conclusion: We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.
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