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MAP Transmission Strategies in IEEE 802.16m
YU, Hyunkyu,KIM, Taeyoung,CHO, Jaeweon,CHOI, Hokyu,PARK, Dong Seek,OH, Seong-Jun The Institute of Electronics, Information and Comm 2009 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.92 No.5
<P>This letter deals with coding and multiplexing strategies for DL/UL MAP transmission in IEEE 802.16m. Separate coding gives a better choice against the joint coding due to the individual users' link adaptation gain. As a multiplexing option, frequency-domain multiplexing outperforms time-domain one in the system-level performance thanks to its flexible power sharing capability between overhead channels and user traffic channels. Overall system-wide performance results are presented with the system level simulation for the various options.</P>
Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain
Park, Hyunkyu,Kim, Donggeon,Kim, Eunmi,Sa, Jason K.,Lee, Hee Won,Yu, Suji,Oh, Jiwon,Kim, Seok-Hyung,Yoon, Yeup,Nam, Do-Hyun MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.9
<P>Hepatocyte growth factor receptor (HGFR, c-Met) is an essential member of the receptor tyrosine kinase (RTK) family that is often dysregulated during tumor progression, driving a malignant phenotypic state and modulating important cellular functions including tumor growth, invasion, metastasis, and angiogenesis, providing a strong rationale for targeting HGF/c-Met signaling axis in cancer therapy. Based on its protumorigenic potentials, we developed IRCR201, a potent antagonistic antibody targeting the plexin-semaphorin-integrin (PSI) domain of c-Met, using synthetic human antibody phage libraries. We characterized and evaluated the biochemical properties and tumor inhibitory effect of IRCR201 in vitro and in vivo. IRCR201 is a novel fully-human bivalent therapeutic antibody that exhibits cross-reactivity against both human and mouse c-Met proteins with high affinity and specificity. IRCR201 displayed low agonist activity and rapidly depleted total c-Met protein via the lysosomal degradation pathway, inhibiting c-Met-dependent downstream activation and attenuating cellular proliferation in various c-Met-expressing cancer cells. In vivo tumor xenograft models also demonstrated the superior tumor inhibitory responsiveness of IRCR201. Taken together, IRCR201 provides a promising therapeutic agent for c-Met-positive cancer patients through suppressing the c-Met signaling pathway and tumor growth.</P>
Low bias frequency domain SNR estimator using DCT in mobile fading channels
Sungtae Kim,Hyunkyu Yu,Jemin Lee,Daesik Hong IEEE 2009 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.8 No.1
<P>The authors analyze the cause of bias in a fast Fourier transform (FFT)-based frequency domain signal-to-noise ratio (SNR) estimator by deriving the upper bound of the bias. The analysis is then used to propose a new frequency domain estimator using discrete cosine transform (DCT), which has lower bias. In addition, a criterion is proposed for use when maximum Doppler frequency information is available; it is based on the derived upper bound and can be used to improve the mean squared error (MSE) performance of the proposed DCT-based estimator. Simulation results show that the proposed estimator reduces the MSE remarkably by diminishing the bias..</P>
A 60-㏈ Image Rejection Single-Side Band Transmitter in InGaP/GaAs HBT Technology
Piljae Park,Hyunkyu Yu,Nak-Woong Eum 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
A single-side band (SSB) transmitter with 60-㏈ image rejection ratio (IRR) is presented in InGaP/GaAs heterojunction bipolar transistor (HBT) technology. To achieve a high image rejection, not only matches between in (I) and quadrature (Q) blocks but also optimal mixer driving is considered. Poly phase filter (PPF) design and its operation for better IRR are shown. To get well matched I/Q signals, Gilbert-cell mixers in the up-converter are operated as a linear multiplier by selecting a proper local oscillator (LO) power. The designed SSB transmitter exploits Hartley topology and it consists of active baluns, two stage PPFs at intermediate frequency (IF) and LO frequency, double balanced I/Q mixers and current mode logic type summer. With 140-㎒ IF and 1060-㎒ LO frequency, proposed design demonstrates image (920 ㎒) rejection ratio of better than 60 ㏈ simultaneously achieving gain and output P1㏈ of 30 ㏈, -1 ㏈m respectively. The measured results are in good agreement with simulation results.