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Chi, Hyung-Joon,Lee, Jae-Seung,Sim, Jae-Yoon,Park, Hong-June The Institute of Electronics and Information Engin 2006 Journal of semiconductor technology and science Vol.6 No.4
A $0.12GHz{\sim}1.4GHz$ DLL-based clock generator with the capability of multiplied four phase clock generation was designed using a 0.18um CMOS process. An adaptive bandwidth DLL with a regulated supply delay line was used for a multiphase clock generation and a low jitter. An extra phase detector (PD) in a reference DLL solves the problem of the initial VCDL delay and achieves a fast lock time. Twice multiplied four phase clocks were generated at the outputs of four edge combiners, where the timing alignment was achieved using a coarse lock signal and the 10 multiphase clocks with T/8 time difference. Those four clocks were combined one more time using a static XOR circuit. Therefore the four times multiplication was achieved. With a 1.8V supply, the rms jitter of 2.1ps and the peak-to-peak jitter of 14.4ps were measured at 1.25GHz output. The operating range is $0.12GHz{\sim}1.4GHz$. It consumes 57mW and occupies 450*325um2 of die area.
A Feasibility Study on a Robotic Exercise System for MDOF Physical Rehabilitation Therapy
Sim, Hyung Joon,Won, Joo Yeon,Han, Chang Soo The Korean Society of Mechanical Engineers 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.11
This paper presents a robot system developed for medical purpose. A 6-degree-of-freedom robot was introduced for physical exercise and rehabilitation. This system was proposed for stroke patients or patients who cannot use one of their arms or legs. The robot system exercises the hemiplegic part based on the motion of normal part of a patient. Kinematic studies on the human body and robot were applied to develop the robotic rehabilitation exercise system. A clamp which acts as an end effector of the robot to hold a patient was designed and applied to the robot to guarantee the safety of patients. The proposed robotic rehabilitation system was verified by simulations and experiments on arm (elbow and shoulder) motion. Patients are expected to be able to exercise various motions by themselves with the proposed robotic rehabilitation system.
A Feasibility Study on a Robotic Exercise System for MDOF Physical Rehabilitation Therapy
Hyung Joon Sim,Joo Yeon Won,Chang Soo Han 대한기계학회 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.11
This paper presents a robot system developed for medical purpose. A 6-degree-of-freedom robot was introduced for physical exercise and rehabilitation. This system was proposed for stroke patients or patients who cannot use one of their arms or legs. The robot system exercises the hemiplegic part based on the motion of normal part of a patient. Kinematic studies on the human body and robot were applied to develop the robotic rehabilitation exercise system. A clamp which acts as an end effector of the robot to hold a patient was designed and applied to the robot to guarantee the safety of patients. The proposed robotic rehabilitation system was verified by simulations and experiments on arm (elbow and shoulder) motion. Patients are expected to be able to exercise various motions by themselves with the proposed robotic rehabilitation system.<br/>
A 0.12㎓-1.4㎓ DLL-based Clock Generator with a Multiplied 4-phase Clock Using a 0.18㎛ CMOS Process
Hyung-Joon Chi,Jae-seung Lee,Jae-Yoon Sim,Hong-June Park 대한전자공학회 2006 Journal of semiconductor technology and science Vol.6 No.4
A 0.12㎓~1.4㎓ DLL-based clock generator with the capability of multiplied four phase clock generation was designed using a 0.18㎛ CMOS process. An adaptive bandwidth DLL with a regulated supply delay line was used for a multiphase clock generation and a low jitter. An extra phase detector (PD) in a reference DLL solves the problem of the initial VCDL delay and achieves a fast lock time. Twice multiplied four phase clocks were generated at the outputs of four edge combiners, where the timing alignment was achieved using a coarse lock signal and the 10 multiphase clocks with T/8 time difference. Those four clocks were combined one more time using a static XOR circuit. Therefore the four times multiplication was achieved. With a 1.8V supply, the rms jitter of 2.1ps and the peak-topeak jitter of 14.4ps were measured at 1.25㎓ output. The operating range is 0.12G㎓ ~ 1.4㎓. It consumes 57㎽ and occupies 450<SUP>*</SUP>325㎛2 of die area.
Inhibitory Effect of the Phenolic Compounds from Apples Against Oxidative Damage and Inflammation
Sim, Jang-Seop,Jeong, Jin-Boo,Lee, Jong-Hwa,Kwon, Tae-Hyung,Cha, Young-Joon,Jeong, Hyung-Jin The Plant Resources Society of Korea 2010 한국자원식물학회지 Vol.23 No.6
ROS have been associated with pathogenic processes including carcinogenesis through direct effect on DNA and play an important role in the pathogenesis of inflammation. Because of many types of phenolic acid derivatives and flavonoids, apples have been one of the human diet since ancient times and are one of the most commonly consumed fruits in worldwide. In this study, catechin, chlorogenic acid and phlorizin dihydrate were purified and identified by HPLC and GC/MS. The contents of catechin, chlorogenic acid and phlorizin dihydrate were 1.01 mg, 7.01 mg and 3.67 mg/ kg wet weight, respectively. Catechin and phlorizin dihydrate were found to significantly inhibit oxidative DNA damage, while chlorogenic did not affect. Also, catechin inhibits NO and $PGE_2$ production via suppressing iNOS and COX-2 expression. However, chlorogenic acid and phlorizin dihydrate did not affect. Our results show that catechin may be the most active phenolic compound in anti-oxidative damage and anti-inflammatory effect.
Sim, Doo Sun,Ahn, Youngkeun,Kim, Yun-Hyeon,Seon, Hyun Ju,Park, Keun Ho,Yoon, Hyun Ju,Yoon, Nam Sik,Kim, Kye Hun,Hong, Young Joon,Park, Hyung Wook,Kim, Ju Han,Jeong, Myung Ho,Cho, Jeong Gwan,Park, Jong The Korean Society of Cardiology 2015 Korean Circulation Journal Vol.45 No.4
<P><B>Background and Objectives</B></P><P>We sought to investigate the relationship between levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the infarct size and left ventricular (LV) volume after acute myocardial infarction (MI).</P><P><B>Subjects and Methods</B></P><P>Eighty-six patients with acute ST-elevation MI underwent delayed enhancement multidetector computed tomography immediately after they underwent percutaneous coronary intervention to determine the infarct size. LV function and remodeling were assessed by echocardiography. Hs-CRP and NT-proBNP were measured at admission, 24 hours and two months later.</P><P><B>Results</B></P><P>Both hs-CRP and NT-proBNP at 24 hours showed a positive correlation with infarct size and a negative correlation with LV ejection fraction at the baseline and two months later. NT-proBNP at two months correlated with infarct size, LV ejection fraction, and LV end diastolic and systolic volume indices at two months. In patients with high NT-proBNP levels at 24 hours and two months, infarct size was larger and LV ejection fraction was lower. NT-proBNP was higher in patients who developed LV remodeling at two months: 929 pg/mL vs. 134 pg/mL, p=0.002. In contrast, hs-CRP at two months showed no relationship to infarct size, LV function, or LV volumes at two months.</P><P><B>Conclusion</B></P><P>Elevated hs-CRP level 24 hours after the onset of acute MI is associated with infarct size and LV dysfunction, whereas elevated levels of NT-proBNP 24 hours and two months after the onset of acute MI are both correlated with infarct size, LV dysfunction, and LV remodeling.</P>