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Choi, H.-J.,Cho, J.-H.,Kim, J.-C.,Seo, H.-J.,Hyun, S.-H.,Kim, G.-H.,Choi, J.-Y.,Choi, H.-J.,Ryu, H.-M.,Cho, J.-H.,Park, S.-H.,Kim, Y.-L.,Han, S.,Kim, C.-D. Blackwell Publishing Ltd 2010 Tissue antigens Vol.76 No.4
<P>Several studies have showed an association of gene polymorphisms with the development of glomerulonephritis (GN). We investigated the effects of gene polymorphisms on the development of GN by analyzing polymorphisms in the interleukin (IL)-18, transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF) genes in Korean patients with primary GN. The study included 146 normal subjects (controls) and 100 patients diagnosed with primary GN by kidney biopsy. The gene polymorphisms A-607C and G-137C in <I>IL-18</I>, C-509T and T869C in <I>TGF-</I>β<I>1</I>, and C-2578A and C405G in <I>VEGF</I> were investigated in DNA extracted from peripheral blood. Significant differences were observed between the GN and control groups in the genotype and allele frequencies of A-607C <I>IL-18</I> and C405G <I>VEGF</I>. The frequencies of the <I>IL-18</I>−607CC genotype [<I>P</I> = 0.001, odds ratio (OR) = 2.473] and the <I>VEGF</I> 405GG genotype (<I>P</I> = 0.001, OR = 2.473) were significantly increased in the GN group. The combination of <I>IL-18</I>−607CC+ and <I>VEGF</I> 405GG+ genotypes had a higher risk for developing GN in comparison with the combination of <I>IL-18</I>−607CC− and <I>VEGF</I> 405GG− genotypes (<I>P</I> < 0.001, OR = 8.642). In the haplotype analysis of the <I>IL-18</I> gene, the CG haplotype was significantly more frequent in the GN group than the control group (61.5% <I>vs</I> 46.9%, <I>P</I> = 0.002). These results show that the −607CC genotype of the <I>IL-18</I> gene and the 405GG genotype of the <I>VEGF</I> gene are associated with susceptibility to and the development of primary GN.</P>
Kim, E.D.,Kim, E.,Lee, J.H.,Hyun, C.K. North-Holland ; Elsevier Science Ltd 2011 european journal of pharmacology Vol.650 No.1
Recently, it has been demonstrated that fibroin and fibroin-derived peptides enhances insulin sensitivity and glucose metabolism in adipocytes. Here, we show that a synthetic hexapeptide Gly-Ala-Gly-Val-Gly-Tyr (GAGVGY) derived from repetitive amino acid sequence of fibroin improves glucose transport and exerts beneficial lipid metabolic effects in 3T3-L1 adipocytes. GAGVGY increases both basal and insulin-stimulated glucose uptake through enhancement of GLUT1 expression and PI 3-K-dependent GLUT4 translocation, respectively. GAGVGY treatment also led to a significant reduction in the expression of lipogenic genes including sterol regulatory element binding protein-1c (SREBP1c), peroxisome proliferator-activated receptor-γ (PPARγ), and fatty acid synthase (FAS) in mature 3T3-L1 adipocytes, which was corroborated with decreased lipid accumulation by GAGVGY treatment. Additionally, in cells undergoing differentiation, mRNA levels of adipogenic genes including PPARγ and CCAAT/enhancer binding protein α (C/EBPα), stearoyl-CoA desaturase 1 (SCD1), and FAS were suppressed by GAGVGY. Furthermore, GAGVGY increased AMP-activated protein kinase (AMPK) phosphorylation and adiponectin secretion in 3T3-L1 adipocytes. The latter effect was supported with evidence showing increased AMPK activation in C2C12 myocytes treated with 3T3-L1-adipocyte-conditioned medium. Together, our data suggest that GAGVGY has multiple beneficial effects on glucose and lipid metabolism, and would control hyperglycemia without the adverse effect of weight gain.
Thermopower Enhancement of Bi2Te3 Films by Doping I Ions
Kim, K. C.,Baek, S. H.,Kim, H. J.,Hyun, D. B.,Kim, S. K.,Kim, J. S. Springer Science + Business Media 2014 Journal of electronic materials Vol.43 No.6
The thermoelectric properties of I-doped Bi2Te3 films grown by metal-organic chemical vapor deposition have been studied. I-doped epitaxial (00l) Bi2Te3 films were successfully grown on 4A degrees tilted GaAs (001) substrates at 360 A degrees C. I concentration in the Bi2Te3 films was easily controlled by the variation in a flow rate of H-2 carrier gas for the delivery of an isopropyliodide precursor. As I ions in the as-grown Bi2Te3 films were not fully activated, they did not influence the carrier concentration and thermoelectric properties. However, a post-annealing process at 400 A degrees C activated I ions as a donor, accompanied with an increase in the carrier concentration. Interestingly, the I-doped Bi2Te3 films after the post-annealing process also exhibited enhancement of the Seebeck coefficient at the same electron concentration compared to un-doped Bi2Te3 films. Through doping I ions into Bi2Te3, the thermopower was also enhanced in Bi2Te3, and a high power factor of 5 x 10(-3) W K-2 m(-1) was achieved.
Hamidian, M. H.,Edkins, S. D.,Joo, Sang Hyun,Kostin, A.,Eisaki, H.,Uchida, S.,Lawler, M. J.,Kim, E.-A.,Mackenzie, A. P.,Fujita, K.,Lee, Jinho,Davis, J. C. Sé,amus Nature Publishing Group, a division of Macmillan P 2016 Nature Vol.532 No.7599
<P>The quantum condensate of Cooper pairs forming a superconductor was originally conceived as being translationally invariant. In theory, however, pairs can exist with finite momentum Q, thus generating a state with a spatially modulated Cooper-pair density(1,2). Such a state has been created in ultracold Li-6 gas(3) but never observed directly in any superconductor. It is now widely hypothesized that the pseudogap phase(4) of the copper oxide superconductors contains such a 'pair density wave' state(5-21). Here we report the use of nanometre-resolution scanned Josephson tunnelling microscopy(22-24) to image Cooper pair tunnelling from a d-wave superconducting microscope tip to the condensate of the superconductor Bi2Sr2CaCu2O8+x. We demonstrate condensate visualization capabilities directly by using the Cooper-pair density variations surrounding zinc impurity atoms(25) and at the Bi2Sr2CaCu2O8+x crystal supermodulation(26). Then, by using Fourier analysis of scanned Josephson tunnelling images, we discover the direct signature of a Cooper-pair density modulation at wavevectors Q(P) approximate to (0.25, 0)2 pi/a(0) and (0, 0.25)2 pi/a(0) in Bi2Sr2CaCu2O8+x. The amplitude of these modulations is about five per cent of the background condensate density and their form factor exhibits primarily s or s' symmetry. This phenomenology is consistent with Ginzburg-Landau theory(5,13,14) when a charge density wave(5,27) with d-symmetry form factor(28-30) and wavevector Q(C) = Q(P) coexists with a d-symmetry superconductor; it is also predicted by several contemporary microscopic theories for the pseudogap phase(18-21).</P>
Hwang, I.H.,Jo, Y.D.,Kim, H.Y.,Kang, J.,Noh, J.Y.,Hyun, M.Y.,Kim, C.,Kim, Y.,Kim, S.J. Pergamon Press 2012 Polyhedron Vol.42 No.1
Three new Mn<SUP>II</SUP>-benzoates coordination polymers containing various bipyridyl ligands (3,3'-dipicoylamine (3), 3-methylisoquinoline (4), and 4,4'-dithiopyridine (5)) and a [Mn<SUB>6</SUB>(O<SUB>2</SUB>CPh)<SUB>10</SUB>(μ<SUB>4</SUB>-OH)<SUB>2</SUB>(CH<SUB>3</SUB>OH)<SUB>3</SUB>(H<SUB>2</SUB>O)].1.5(C<SUB>4</SUB>H<SUB>4</SUB>N<SUB>2</SUB>) cluster (1) have prepared and their structures were determined. The bipyridyl ligands can act as bridging ligands to produce 1-D or 2-D polymeric compounds. The pyrazine produced a Mn<SUB>6</SUB> cluster molecule, and 3-methylisoquinoline did a benzoate-bridged 1-D Mn<SUP>II</SUP> compound. The Mn<SUB>6</SUB> cluster (1) and 1-D Mn<SUP>II</SUP> compounds (3) and (4) show antiferromagnetic property. The compounds 1, 3, and 4 have catalyzed efficiently the transesterification of a variety of esters, while 5 has displayed a very slow conversion. The thermal stabilities of these complexes were also examined.
ZnO 나노막대가 형성된 STO기판에 증착한 Y-Ba-Cu-O 박막의 미세구조 분석
오세권,장건익,강병원,김경원,이초연,현옥배,Oh, S.K.,Jang, G.E.,Tran, H.D.,Kang, B.W.,Kim, K.W.,Lee, C.Y.,Hyun, O.B. 한국초전도학회 2009 Progress in superconductivity Vol.11 No.1
For many large-scale applications of high-temperature superconducting materials, large critical current density ($J_c$) in high applied magnetic fields are required. A number of methods have been reported to introduce artificial pinning centers in $YBa_2Cu_3O_{7-{\delta}}$ films for enhancement of their $J_c$. We studied the microstructures and characteristic of $YBa_2Cu_3O_{7-{\delta}}$ films fabricated on $SrTiO_3$ (100) substrates with ZnO nanorods as pinning centers. Au catalyst nanoparticles were synthesized on STO substrates with self assembled monolayer to control the number of ZnO nanorods. The density of Au nanoparticles is approximately $240{\sim}260{\mu}m^{-2}$ with diameters of $41{\sim}49nm$. ZnO nanorods were grown on STO by hot-walled PLD with Au nanoparticles. Typical size of ZnO nanorod was around 179 nm in diameter and $2{\sim}6{\mu}m$ in length respectively. YBCO films deposited directly on STO substrates show the c-axis orientation, while YBCO films with ZnO nanorods exhibit any mixed phases without any typical crystal orientation.
고체철과 평형하는 FetO-CaO-CaF2 계 슬래그의 열력학
이응조,현도빈,심재동 대한금속재료학회(대한금속학회) 1987 대한금속·재료학회지 Vol.25 No.2
As a fundamental study on the physico-chemical properties of slags containing fluoride ion, a measurement has been made on the activity at the equilibrium of hydrogenwater vapor gas mixtures with the slags of Fe_tO-CaO-CaF₂ ternary system contained in solid iron crucible at 1400℃. From the results obtained, the activity of iron oxide and the ratio of ferrous to ferric iron (Λ=Fe^(3+)/Fe^(2+)) have been determined as a function of slag composition. The addition of F- anions increased the activity coefficient of iron oxide exponentially, but it seemed to be independent on Λ-values. The obtained results are as follows, lnγ_(Fe_tO)/lnγ^0_(Fe_tO) =1.78 N_F-
Fet O-Na2O-SiO2 계 슬라그의 열력학적 성질
이응조,현도빈,심재동,김성만 대한금속재료학회(대한금속학회) 1985 대한금속·재료학회지 Vol.23 No.3
As a fundamental study on the physicochemical properties of soda-bearing slags, an equilibrium measurement between hydrogen/water vapour mixtures and the soda-bearing stags of Fe_tO-Na₂O-SiO₂ternary system contained in solid iron crucible at 1400℃ has been made. From the results obtained, the activity of iron oxide and the ratio of Ferric to ferrous in (Fe^(3+)/Fe^(2+)) have been determined as a function of slag composition. The activity of iron oxide in this slag markedly deviated to the direction of N_(Na₂)O/N_(SiO₂)=⅔. In the view of ionic theory, the approximate validity of regular solution model for cations was examined to evaluate the thermodynamic properties of this ternary slag containing Na₂O. It was confirmed that the regular solution model was satisfied within experimental error except for extremely FeO rich region.
저탄소 2% Mn 강 및 2% Mn-Nb-V 강의 냉간압연후(冷間壓延後)의 시효처리효과 : Ⅱ. Splitting 현상
맹선재,강찬형,현도빈,정순효 대한금속재료학회(대한금속학회) 1982 대한금속·재료학회지 Vol.20 No.10
Splitting behavior of tensile specimens of low carbon 2% Mn steel and 2% Mn-Nb-V steel that had been cold rolled and aging treated were studied. The occurrence of splitting depends on steel composition, degree of cold reduction and aging treatment conditions. The susceptibility to splitting is closely related to the weakness of ferrite grain boundaries This weakness is attributed to elongation of the ferrite grains in the direction of cold rolling and also to precipitation and growth of carbides at the grain boundaries during the aging treatment.