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( Junhyung Kim ),( Jae-ho Guk ),( Seung-hyun Mun ),( Hyokeun Song ),( Je Kyung Seong ),( Jun Gyo Suh ),( Seongbeom Cho ) 대한인수공통전염병학회 2019 창립총회 및 학술대회 초록집 Vol.2019 No.1
Introduction: It has been known that the main causes of human campylobacteriosis are livestock including poultry and cattle. In addition to livestock, there have been a possibility that wild animals may affect the transmission of Campylobacter jejuni. Therefore, the current study was conducted to determine whether or not wild animal, particularly wild mice, can cause Campylobacter infection in other hosts. Methods: C. jejuni was isolated from fecal samples of wild mice. Then, the genome of wild mouse-derived C. jejuni was completely sequenced and comparative genomic analysis with 19 genome sequences of other sources-derived C. jejuni was carried out. Results: The complete genome of wild mouse-derived C. jejuni was composed of 3 contigs, one chromosome (1,737,053bp) and two plasmid (86,091bp and 36,143bp, respectively). The genome had a total of 1,781 coding genes, 44 tRNA, 9 rRNA, and 3 ncRNA. Based on virulence factor database, these genomes contained the most virulence related genes including adherence, colonization, glycosylation system, immune evasion, invasion, toxin, motility, and secretion system. Based on comprehensive antibiotic resistance database, the strain was expected to be susceptible to all antibiotics, and these results were confirmed by the antibiotic resistance test (MIC and disk diffusion test). In comparative genomic analysis, wild mouse-derived C. jejuni was not clustered together with other sources-derived C. jejuni based on tetra nucleotide-derived dendrogram and pan-genome orthologous groups (POG) analysis. Conclusion: C. jejuni might be a normal microorganism in the gastrointestinal tract of M. minutus, and wild mice are not expected to be associated with Campylobacter infections in other hosts including humans and livestock. This study would be the basis for further studies on C. jejuni in wild animals.