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신종감염병 환자를 돌보는 정신과 간호사의 감염관리지식, 응급간호역량, 감염예방환경이 소진에 미치는 영향
조혜란 ( Cho Hyeran ),백수연 ( Baek Suyon ) 한국정신간호학회 2023 정신간호학회지 Vol.32 No.4
Purpose: Psychiatric nurses lack experience caring for patients with acute physical illnesses. Notably, they are expected to have experienced burnout when they were taking care of mentally ill patients infected with COVID-19. This study aimed to determine the impact of infection control knowledge, emergency nursing competency, and infection prevention environment on burnout. Methods: This survey was conducted on 127 psychiatric nurses from February to March 2023 using a structured self-report questionnaire. The collected data were analyzed through multiple regression analysis using the SPSS 28.0 program. Results: The subject's burnout score was 2.83 out of 5, infection control knowledge was 0.69 out of 1, emergency nursing competency was 2.80 out of 4, and infection prevention environment was 3.83 out of 5. Regression analysis showed infection control knowledge (β=-.17, p=.048) and nurses’ self-perceived efficacy in responding to an emergency (β=.26, p=.002) were factors affecting burnout, and the explanatory power for burnout was 9% (F=7.22, p<.001). Conclusion: Based on these results, we believe that infection control is needed. In addition, rather than simply providing education to increase nurses' emergency nursing competence, educational measures are needed to increase nurses' sense of efficacy in responding to emergencies.
Comprehensive profiling of DNA methylation in Korean patients with colorectal cancer
( Hyeran Shim ),( Kiwon Jang ),( Yeong Hak Bang ),( Hoang Bao Khanh Chu ),( Jisun Kang ),( Jin-young Lee ),( Sheehyun Cho ),( Hong Seok Lee ),( Jongbum Jeon ),( Taeyeon Hwang ),( Soobok Joe ),( Jinyeo 생화학분자생물학회 2024 BMB Reports Vol.57 No.2
Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), and conducted an in-depth investigation of cancer-specific methylation patterns. Our analysis of the tumor samples revealed a significant presence of hypomethylated probes, primarily within the gene body regions; few hypermethylated sites were observed, which were mostly enriched in promoter-like and CpG island regions. The CpG Island Methylator Phenotype- High (CIMP-H) exhibited notable enrichment of microsatellite instability-high (MSI-H). Additionally, our findings indicated a significant correlation between methylation of the MLH1 gene and MSI-H status. Furthermore, we found that the CIMP-H had a higher tendency to affect the right-side of the colon tissues and was slightly more prevalent among older patients. Through our methylome profile analysis, we successfully verified the methylation patterns and clinical characteristics of Korean patients with CRC. This valuable dataset lays a strong foundation for exploring novel molecular insights and potential therapeutic targets for the treatment of CRC.