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Hyeongseok Jeon,Keung Nyun Kim 대한척추신경외과학회 2015 Neurospine Vol.12 No.3
C5 palsy is a common complication after cervical decompressive surgery, which have 0 to 30% complication rate. A 61-year-old female patient with cervical spondylotic myelopathy showed bilateral C5 palsy following circumferential decompression and fusion. Unexpectedly, bilateral C5 palsy was noted in different time points on postoperative day 2 and 8, respectively. Steroid injection and physical therapy were performed, and her motor function is recovering. Surgeons should make an effort to prevent possible C5 palsy when performing cervical decompression surgery.
Jeon, Hyeongseok,Shin, Dong Ah The Korean Spinal Neurosurgery Society 2015 Neurospine Vol.12 No.3
<P><B>Objective</B></P><P> Brain computer interface (BCI) is one of the most promising technologies for helping people with neurological disorders. Most current BCI systems are relatively expensive and difficult to set up. Therefore, we developed a P300-based BCI system with a cheap bioamplifier and open source software. The purpose of this study was to describe the setup process of the system and preliminary experimental results.</P><P><B>Methods</B></P><P>Ten spinal cord-injured patients were recruited. We used a sixteen-channel EEG(KT88-1016, Contec, China) and BCI2000 software (Wadsworth center, NY, USA). Subjects were asked to spell a 5-character word using the P300-based BCI system with 10 minutes of training. EEG data were acquired during the experiment. After subjects spelled the word for ten trials, the spelling accuracy and information transfer rate (ITR) were obtained in each patients.</P><P><B>Results</B></P><P>All subjects performed the experiment without difficulty. The mean accuracy was 59.4±22.8%. The spelling accuracy reversely correlated with the age. Younger subjects spelled with higher accuracy than older subjects (p=0.018). However, sex, injury level, time since injury and ASIA scale were not correlated with the accuracy. The mean of ITR was 2.26±1.22 bit/min.</P><P><B>Conclusion</B></P><P>This study showed that a BCI system can be set up inexpensively with a low-price bioamplifier and open-source software. The spelling accuracy was moderately achieved with our system. P300-based BCI is useful in young patients, but modification is necessary in old patients who have low ability of recognition and concentration.</P>
IoT 헬스케어 기기에서의 중간자 공격 방어를 위한 디지털 서명 알고리즘 분석과 구현
전형석(Hyeongseok Jeon),이성기(Sungkee Lee) 한국정보기술학회 2021 한국정보기술학회논문지 Vol.19 No.9
MITM(Man-In-The-Middle) attacks can directly or indirectly harm users health by leaking and modulating user information, vital sign data from IoT healthcare devices, and causing them to malfunction. In this paper, we analyzed and applied digital signature algorithms to defend against MIMT attacks on IoT healthcare devices having low system resources, and we also defined the light-weight digital certificate. After implementing and testing three digital signature algorithms that offer a 128-bit of security level on four MCU boards which are used in IoT healthcare devices, we found that the ECDSA using secp256k1 elliptic curve was excellent in terms of execution and speed. To verify that ECDSA and the light-weight certificate can defend against MITM attacks on IoT healthcare devices, we simulated a IoT Healthcare device in a remote update situation and a MITM attack. As a result, we prove that the MITM attacker was unable to intervene in the network connection between the simulated IoT Healthcare device and the update server which are ECDSA and the light-weight certificate applied.
IHE MHD 메타데이터와 IHE XDS.b 메타데이터의 자동 변환
전형석 ( Hyeongseok Jeon ),이장수 ( Jangsoo Lee ),도형호 ( Dongwook Park ),이성기 ( Hyoungho Do ),( Sungkee Lee ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.2
IHE(Integrating the Healthcare Enterprise)의 XDS.b(Cross-Enterprise Document Sharing.b) 프로파일은 의료기관간 환자의 전자진료기록을 공유하기 위해 개발되었으나 모바일 환경을 고려하지 않았다. 이를 보완하고자 IHE 에서는 모바일기기에서도 전자진료기록을 공유할 수 있는 MHD(Mobile access to Health Documents) 프로파일을 개발했다. XDS.b 메타데이터는 ebXML(electronic business XML)을 사용하고 MHD 메타데이터는 JSON(JavaScript Object Notation)을 사용하므로 MHD와 XDS.b를 연동하기 위해서는 MHD 메타데이터를 XDS.b 메타데이터로 변환이 필요하다. 본 논문에서는 MHD 메타데이터를 XDS.b 메타데이터로 변환하는 규칙을 정의했다.
IoT 헬스케어 기기의 원격 업데이트 보안을 위한 암호화 알고리즘 분석과 구현
전형석(Hyeongseok Jeon),이성기(Sungkee Lee) 한국정보기술학회 2021 한국정보기술학회논문지 Vol.19 No.7
When IoT healthcare devices are updated remotely, information such as user, device authentication, and the source code are vulnerable to leak by sniffing attacks. Through the binary code analysis of the leaked source code, device control commands, data transmission format, and security functions could be leaked, allowing a secondary attack by utilizing the device. In this paper, we analyzed and applied encryption algorithms to defend against sniffing attacks while remote updating IoT healthcare devices having limited system resources. As testing results of algorithms implemented on MCU boards, which are mainly used in IoT healthcare devices, we found that the ChaCha20 encryption algorithm has sufficient security performance to defend against sniffing attacks and is excellent in terms of speed and memory usage. We also showed that, by implementing the ChaCha20 algorithm, the malicious use of the source codes for remote updates is prevented from sniffing attacks.
전형석(Hyeongseok Jeon),이성기(Sungkee Lee) 한국정보기술학회 2021 한국정보기술학회논문지 Vol.19 No.1
Due to the growing interest in health care in everyday life and advances in the internet technology, IoT healthcare devices are widely used at home. However, despite the fact that IoT healthcare devices generate very sensitive health information, security measures are very low because of devices capacity limitation. During the remote update of the device software over network which is called over-the-air (OTA) programming, OTA update protocols and binary codes can be leaked by security attacks that leads to sensitive information leaks, or the devices are suffered from secondary attacks by malicious use of the leaked sensitive information. In this paper, we analyzed the vulnerabilities of OTA updates of IoT healthcare devices and demonstrated them by simulating the real-world security attacks. In the simulation, OTA update protocols and binary codes are captured by executing the sniffing attacks, the device operation information is obtained through reverse engineering, and demonstrated the disabling of the device by installing a dummy program.
( Nari Lee ),( Hyeongseok Yun ),( Chan Lee ),( Yikjae Lee ),( Euna Kim ),( Sumi Kim ),( Hyoeun Jeon ),( Chiho Yu ),( Jaerang Rho ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Organophosphorus nerve agents (OPNAs), including both G- and V-type nerve agents such as sarin, soman, tabun and VX, are extremely neurotoxic organophosphorus compounds. Catalytic bioscavengers capable of hydrolyzing OPNAs are under development because of the low protective effects and adverse side effects of chemical antidotes to OPNA poisoning. However, these bioscavengers have certain limitations for practical application, including low catalytic activity and narrow specificity. In this study, we generated a fusion-hybrid form of engineered recombinant human paraoxonase 1 (rePON1) and bacterial organophosphorus hydrolase (OPH), referred to as GV-hybrids, using a flexible linker to develop more promising catalytic bioscavengers against a broad range of OPNAs. These GV-hybrids were able to synergistically hydrolyze both G-type OPNA analogs (paraoxon: 1.7 ~ 193.7-fold, p-nitrophenyl diphenyl phosphate (PNPDPP): 2.3 ~ 33.0-fold and diisopropyl fluorophosphates (DFP): 1.4 ~ 22.8-fold) and V-type OPNA analogs (demeton-S-methyl (DSM): 1.9 ~ 34.6-fold and malathion: 1.1 ~ 4.2-fold above) better than their individual enzyme forms. Among the GV-hybrid clones, the GV7 clone showed remarkable improvements in the catalytic activity toward both G-type OPNA analogs (k<sub>cat</sub>/K<sub>m</sub> (10<sup>6</sup> M<sup>-1</sup> min<sup>-1</sup>): 59.8 ± 0.06 (paraoxon), 5.2 ± 0.02 (PNPDPP) and 47.0 ± 6.0 (DFP)) and V-type OPNA analogs (k<sub>cat</sub>/K<sub>m</sub> (M<sup>-1</sup> min<sup>-1</sup>): 504.3 ± 48.5 (DSM) and 1324.0 ± 47.5 (malathion)). In conclusion, we developed GV-hybrid forms of rePON1 and bacterial OPH mutants as effective and suitable catalytic bioscavengers to hydrolyze a broad range of OPNA analogs.