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Hyeongjin Cho,Dong Yoon Lee,Suja Shrestha,Yi Sup Shim,Ki Chul Kim,Mee-Kyung Kim,Keun-Hyeung Lee,Jonghwa Won,강재승 한국분자세포생물학회 2004 Molecules and cells Vol.18 No.1
Aurintricarboxylic acid (ATA) prevents apoptosis in a diverse range of cell types including PC12 cells. It is known to stimulate tyrosine phosphorylation of signaling proteins including Shc proteins, phosphatidylinositol 3-kinase, phospholipase C-γ and mitogen-activated protein kinases (MAPKs). However, it has been unclear how ATA increases the phosphorylation of these proteins as it was believed to be membrane impermeable. We found that ATA translocates across the plasma membrane of PC12 cells and have confirmed that it is a potent inhibitor of protein tyrosine phosphatases (PTP ases). Other PTPase inhibitors also prevented apoptosis independent of ATA. These observations indicate that ATA exerts its anti-apoptotic effect on PC12 cells at least in part by inhibiting certain PTPase(s).
Hyeongjin Shim,김선영,Miji Kim,Byung-Sung Kim,Eunjin Jeong,Young Ju Lee,Chang Won Won 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.3
Background: In older adults, the risk of frailty is higher among those who are unmarried than among those who are married. However, no study has reported about the relationship between cohabitation status and frailty. Methods: This cross-sectional study included 2,128 community-dwelling adults aged between 70 and 84 years who underwent interviews and physical function assessments for the Korean Frailty and Aging Cohort Study. The definition of frailty was derived from the Fried frailty phenotype. Cohabitation was categorized as “living alone”, “with spouse only”, “with children only”, and “with spouse and children”. Results: The mean age was 76 years, and 46.3% of the adults were men. After adjusting for age, education, income, nutritional status, alcohol, smoking history, Geriatric Depression Scale, Mini-Mental State Examination, Korean Activities of Daily Living, Korean Instrumental Activities of Daily Living, urinary incontinence, and polypharmacy, the odds ratios of frailty were 0.323 (95% confidence interval [CI], 0.137–0.763; p
Safety and Lung Damage Reduction Activity of Morinda citrifolia (noni) seed
Hyeongjin Eom,Dongyup Hahn 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Noni used in food and folk remedies for over 2000 years. Recently, the consumption of noni products has increased, as there is a growing interest in noni as various bioactivity has been revealed. But, anthraquinone, one of the components of noni, causes side effects like hepatotoxicity in some papers. It was present in the husk and seeds. Accordingly, it is important to explore bioactive components while excluding anthraquinone. Meanwhile, it is considered that fine dust is the cause of respiratory disease. It consists of minerals, nitrogen oxide, sulfur oxide, and volatile organic compounds. 1-Nitropropane (1-NP), constituting fine dust, have toxicity to lung cells. In this study, Noni seed was extracted with dichloromethane: methanol (1: 1) solution and then fractionated hexane, ethyl acetate, butanol, and water layer. The ethyl acetate layer was subdivided by size exclusion chromatography, and some components were separated using preparative HPLC. 1H-NMR and 13C-NMR were used for components structure elucidation isolated from noni seed. 1-NP had been tested into lung cells with lignans from noni seed, and cell viability was analyzed compared to those not treated.