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Sudipta Chowdhury,Mohammad Marufuzzaman,Huseyin Tunc,Linkan Bian,William Bullington 한국CDE학회 2019 Journal of computational design and engineering Vol.6 No.3
This study presents a novel Ant Colony Optimization (ACO) framework to solve a dynamic traveling sales-man problem. To maintain diversity via transferring knowledge to the pheromone trails from previous environments, Adaptive Large Neighborhood Search (ALNS) based immigrant schemes have been devel-oped and compared with existing ACO-based immigrant schemes available in the literature. Numerical results indicate that the proposed immigrant schemes can handle dynamic environments efficiently com-pared to other immigrant-based ACOs. Finally, a real life case study for wildlife surveillance (specifically, deer) by drones has been developed and solved using the proposed algorithm. Results indicate that the drone service capabilities can be significantly impacted when the dynamicity of deer are taken into consideration.
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Factors associated with surgical morbidity of primary debulking in epithelial ovarian cancer
( Emre Gunakan ),( Yusuf Aytac Tohma ),( Mehmet Tunc ),( Huseyin Akıllı ),( Hanifi Şahin ),( Ali Ayhan ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.1
Objective Epithelial ovarian cancer (EOC) requires an aggressive surgical approach. The important part of literature on ovarian cancer surgery emphasize residual tumor and survival analyses. Morbidity issue keeps in background. Therefore, we aimed to report on morbidity of cytoreductive surgery for EOC in this study. Methods EOC patients who underwent primary debulking were evaluated. Intraoperative and postoperative complications that occurred within 30 days after the surgery and factors that affect morbidity were considered. Results The study involved 359 patients. Forty-six intraoperative complications occurred in 42 (11.6%) patients. Advanced stage and cancer antigen level of 125 were independently and significantly associated with operative complications (hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.01-2,73; P=0.044, and HR, 1.47; 95% CI, 1.05-2.06; P=0.025, respectively). The need for intensive care unit admission was significantly higher in patients with intraoperative complications (28.6% vs. 8.8%, P=0.001). Intraoperative and postoperative complication rates were significantly higher in extended surgery than in standard surgery (18.9%vs. 8.5%, P=0.005 and 38.7% vs. 10.9%, P<0.001, respectively). Intraoperative and postoperative transfusion need, hospital stay duration, and chemotherapy start day were also significantly higher in extended surgery than in standard surgery. Hundred postoperative complications occurred in 70 patients. Age, extended surgery, presence of ascites, and presence of operative complications were independently and significantly associated with postoperative complications. Conclusion Morbidity of extensive surgical approach should be kept in mind in ovarian cancer surgery aimed at leaving no residual tumor. Patient-based management with an appropriate preoperative evaluation may avoid morbidity of extended/extensive surgical approaches.
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