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Numerical Modelling and Design of Stainless Steel Double Extended End-Plate Beam-to-Column Joints
Huanxin Yuan,Jundong Gao,Marios Theofanous 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.6
The structural performance of stainless steel beam-to-column joints with double extended end-plate connections is numerically studied in this paper. Finite element (FE) models were developed and validated against previously reported experimental results including static and cyclic loading tests on stainless steel double extended end-plate beam-to-column joints. Based upon the validated FE models, parametric studies were carried out to examine the impact of key parameters, such as the stainless steel grade, the bolt pretension force, the column axial force, the end-plate thickness, the bolt diameter and the presence of rib stiff eners, on the structural behaviour of stainless steel beam-to-column joints. The component method specifi ed in EN 1993-1-8 for design of joints was used to develop a modifi ed design method, which accounts for the strain hardening characteristics of stainless steel and the strengthening eff ect of the rib stiff eners. Moreover, the infl uence of the panel zone thickness and the end-plate thickness on the hysteretic performance of stainless steel joints was explored, and the ability of the modifi ed method to accurately predict the hysteretic properties of joints under cyclic loading was also demonstrated. It can be concluded that the newly proposed design approach based on the component method leads to more accurate predictions of both the static and the hysteretic properties of stainless steel end-plate beam-to-column joints.
Bearing Capacity of Non-linear Metallic Spiders Used in Point Supported Glass Facades
Yuanqing Wang,Huanxin Yuan,Yongjiu Shi,Yu Zou 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.2
Experimental and numerical investigations on bearing capacity of non-linear metallic spiders used in glass facades were presented. The non-linear metallic materials adopted in this study included two aluminum alloys (ZL105-T1 and ZL111-T6)and one austenitic stainless steel (AISI 302). A total of 21 spider specimens including three types of configurations were tested. Numerical simulation of the tests was conducted by virtue of sophisticated finite element (FE) models built up with ANSYS software. The test and FE predicted results were used to develop new design proposals for the spiders. Evaluation of the proposed design formulae revealed that a comparatively large safety margin would be appropriate in consideration of brittle glass panels. Finally, safety assessment of the spiders was conducted based upon a practical engineering application-the exhibition greenhouse in Beijing Botanical Garden.
Deyu Li,Qin Tong,Yuane Lian,Zhizhong Chen,Yaru Zhu,Weimei Huang,Yang Wen,Qiongyao Wang,Shumei Liang,Man Li,Jianjing Zheng,Zhenhua Liu,Huanxin Liu,Linlang Guo 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose Drug resistance is one of the main causes of chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into chemotherapy drug resistance are required. Materials and Methods In this study, we performed lncRNA microarray, in vitro functional assays, in vivo models and cDNA microarray to evaluate the impact of lncRNA in SCLC chemoresistance. Results The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-β1 mediated epithelial-to-mesenchymal transition in SCLC cells. Conclusion Taken together, our study revealed the role of KCNQ1OT1 in the progression and chemoresistance of SCLC, and suggested KCNQ1OT1 as a potential diagnostic and prognostic biomarker in SCLC clinical management.
Experimental Study of Lateral-torsional Buckling Behavior of Stainless Steel Welded I-section Beams
Yuanqing Wang,Lu Yang,Bo Gao,Yong-Jiu Shi,Huanxin Yuan 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.2
Investigations on lateral-torsional buckling behavior of stainless steel welded I-section beams were carried out through fourpointbending tests. The Chinese austenitic stainless steel adopted in this study contains approximately 17% of Cr, which couldbe graded as EN 1.4401. The non-linear stress-strain relationship of the material, the residual stress distribution of the sectionand the ultimate moment capacity of the welded I-section beams were obtained from the experiments, and they were comparedwith those results predicted by analytical models recommended by several researchers. Besides, a new model is proposed topredict the residual stress distribution of the stainless steel welded I-section beams.