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- 저자 : Hsu Mei-Feng (검색결과 3 건)
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Hsu Mei-Feng,Whu Yew-Wha,Lin I-Chen,Liu Chieh-Yu,Lai Fei-Chen,Liu Pei-Ching,Chen Chi-Wen 한국간호과학회 2022 Asian Nursing Research Vol.16 No.2
Purpose This study aimed to evaluate the effectiveness of an interactive virtual reality (VR) play intervention including instructional play and emotional catharsis play sessions in reducing children's pain and fear during intravenous placement. Methods A randomized controlled trial with parallel groups was conducted. The sample consisted of 134 hospitalized children aged 6–12 years (intervention group: n = 69; comparison group: n = 65). The intervention involved one immersive intravenous scene in VR before the actual intravenous placement and one emotional catharsis VR play after injection. The comparison group received an educational photo book about intravenous placement before receiving intravenous placement. The children and their caregivers rated their pain and fear by using the Wong–Baker FACES Pain Rating Scale and the Children's Fear Scale. The time required for successful intravenous insertion was also compared between the two groups. Results Children's pain (p = .028) and fear scores (p = .004) were significantly lower in the intervention group than in the comparison group. Their caregivers' pain and fear scores (both p < .001) were significantly lower in the intervention group. The time required for successful intravenous insertion did not differ significantly between the intervention and comparison groups. Conclusions The interactive play intervention with VR effectively reduced children's levels of pain and fear during the intravenous placement procedure. The results of this study can serve as a reference for the implementation of a feasible, child-friendly care practice for clinical intravenous placement in school-aged children.
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Moayyeri, Alireza,Hsu, Yi-Hsiang,Karasik, David,Estrada, Karol,Xiao, Su-Mei,Nielson, Carrie,Srikanth, Priya,Giroux, Sylvie,Wilson, Scott G.,Zheng, Hou-Feng,Smith, Albert V.,Pye, Stephen R.,Leo, Paul J IRL Press 2014 Human molecular genetics Vol.23 No.11
<P>Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; <I>n</I> = 14 260), velocity of sound (VOS; <I>n</I> = 15 514) and BMD (<I>n</I> = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (<I>in silico n</I> = 11 452) and new genotyping in 15 cohorts (<I>de novo n</I> = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (<I>P</I> < 5 × 10<SUP>−8</SUP>) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including <I>ESR1</I> (6q25.1: rs4869739, rs3020331, rs2982552), <I>SPTBN1</I> (2p16.2: rs11898505), <I>RSPO3</I> (6q22.33: rs7741021), <I>WNT16</I> (7q31.31: rs2908007), <I>DKK1</I> (10q21.1: rs7902708) and <I>GPATCH1</I> (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to <I>TMEM135</I>, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (<I>P</I> < 8.23 × 10<SUP>−14</SUP>). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at <I>P</I> < 5 × 10<SUP>−6</SUP> also had the expected direction of association with any fracture (<I>P</I> < 0.05), including three SNPs with <I>P</I> < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.</P>
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