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Hierarchical Silicon Nanospikes Membrane for Rapid and High-Throughput Mechanical Cell Lysis
So, Hongyun,Lee, Kunwoo,Seo, Young Ho,Murthy, Niren,Pisano, Albert P. American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.10
<P/><P>This letter reports an efficient and compatible silicon membrane combining the physical properties of nanospikes and microchannel arrays for mechanical cell lysis. This hierarchical silicon nanospikes membrane was created to mechanically disrupt cells for a rapid process with high throughput, and it can be assembled with commercial syringe filter holders. The membrane was fabricated by photoelectrochemical overetching to form ultrasharp nanospikes in situ along the edges of the microchannel arrays. The intracellular protein and nucleic acid concentrations obtained using the proposed membrane within a short period of time were quantitatively higher than those obtained by routine, conventional acoustic and chemical lysis methods.</P>
So, Hongyun,Park, Woosung Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.473 No.-
<P><B>Abstract</B></P> <P>The enhanced optical sensitivity of gallium nitride (GaN) ultraviolet (UV) photodetectors is demonstrated using attachable and hydrophobic freezing-delayed surfaces. The GaN surface attached to microfabricated surfaces with an array of pyramid structures reduced the surface reflectance compared with that of bare GaN surface (∼43.3% decrease at 365 nm wavelength). In addition, as the operation temperature decreased, the hydrophobic pyramid microstructures prevented rapid frost formation by generating dispersed and small-sized frosts (ice crystals). Consequently, the photodetectors fabricated using hydrophobic surfaces with pyramid microstructures showed higher sensitivity (∼48.5% increase in the temperature range of −14 °C to 0 °C) compared to the photodetectors on bare GaN surfaces, supporting the use of hydrophobic surfaces composed of microstructures for UV sensing with higher sensitivity in low-temperature environments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Attachable and hydrophobic freezing-delayed surface was employed for photodetectors. </LI> <LI> Pyramid microstructures reduced the surface reflectance of GaN in the UV region. </LI> <LI> Simple textured surface generated dispersed and small-sized frosts on GaN surface. </LI> <LI> Higher sensitivity was achieved at low temperatures compared to the bare design. </LI> </UL> </P>
So, Hongyun,Pisano, Albert P,Seo, Young Ho Royal Society of Chemistry 2014 Lab on a chip Vol.14 No.13
<P>This paper presents a microfluidic pump operated by an asymmetrically deformed membrane, which was inspired by caterpillar locomotion. Almost all mechanical micropumps consist of two major components of fluid halting and fluid pushing parts, whereas the proposed caterpillar locomotion-inspired micropump has only a single, bilaterally symmetric membrane-like teardrop shape. A teardrop-shaped elastomeric membrane was asymmetrically deformed and then consecutively touched down to the bottom of the chamber in response to pneumatic pressure, thus achieving fluid pushing. Consecutive touchdown motions of the teardrop-shaped membrane mimicked the propagation of a caterpillar's hump during its locomotory gait. The initial touchdown motion of the teardrop-shaped membrane at the centroid worked as a valve that blocked the inlet channel, and then, the consecutive touchdown motions pushed fluid in the chamber toward the tail of the chamber connected to the outlet channel. The propagation of the touchdown motion of the teardrop-shaped membrane was investigated using computational analysis as well as experimental studies. This caterpillar locomotion-inspired micropump composed of only a single membrane can provide new opportunities for simple integration of microfluidic systems.</P>