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- 저자 : Hongxin Liao (검색결과 4 건)
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Effect on Zn on Microstructures and Mechanical Properties of Mg–Gd–Y–Zn LPSO Alloys
Jonghyun Kim,Hongxin Liao,Xiang Ou,Zhaobin Zhang,Kaikai Kang,Taekyung Lee,Fusheng Pan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
In this study, the microstructures and mechanical properties of Mg–1Gd–1Y–xZn alloys (x = 0.2, 0.4, 0.6, and 0.8) wereinvestigated. Microstructural evolution was tracked during the process of casting, homogenization, and extrusion. Long-periodstacking-ordered (LPSO) and β phases were formed in the as-cast alloys. The volume fraction of the LPSO phase increasedwith increasing Zn content, whereas that of the β phase decreased. Although the homogenization dissolved the β phase intothe Mg matrix, there was no significant change in the volume fraction of the LPSO phases. Increasing the Zn content led toa slight reduction in grain size and a simultaneous strengthening of texture. The Mg–1Gd–1Y–0.2Zn alloy possessed a highdensity of fine LPSO phases and excellent reinforcement capacity, thereby exhibiting excellent mechanical properties atroom temperature. In addition, the low volume fraction of the LPSO phases in this alloy led to suppressed yield asymmetry.
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Hongyan Nie,Hongxin Liao,Jinrui Wen,Cuiqiong Ling,Liyan Zhang,Furong Xu,Xian Dong The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2
Background: Fusarium oxysporum (F. oxysporum) is the primary pathogenic fungus that causes Panax notoginseng (P. notoginseng) root rot disease. To control the disease, safe and efficient antifungal pesticides must currently be developed. Methods: In this study, we prepared and characterized a nanoemulsion of Foeniculum vulgare essential oil (Ne-FvEO) using ultrasonic technology and evaluated its stability. Traditional Foeniculum vulgare essential oil (T-FvEO) was prepared simultaneously with 1/1000 Tween-80 and 20/1000 dimethyl sulfoxide (DMSO). The effects and inhibitory mechanism of Ne-FvEO and T-FvEO in F. oxysporum were investigated through combined transcriptome and metabolome analyses. Results: Results showed that the minimum inhibitory concentration (MIC) of Ne-FvEO decreased from 3.65 mg/mL to 0.35 mg/mL, and its bioavailability increased by 10-fold. The results of gas chromatography/mass spectrometry (GC/MS) showed that T-FvEO did not contain a high content of estragole compared to Foeniculum vulgare essential oil (FvEO) and Ne-FvEO. Combined metabolome and transcriptome analysis showed that both emulsions inhibited the growth and development of F. oxysporum through the synthesis of the cell wall and cell membrane, energy metabolism, and genetic information of F. oxysporum mycelium. Ne-FvEO also inhibited the expression of 2-oxoglutarate dehydrogenase and isocitrate dehydrogenase and reduced the content of 2-oxoglutarate, which inhibited the germination of spores. Conclusion: Our findings suggest that Ne-FvEO effectively inhibited the growth of F. oxysporum in P. notoginseng in vivo. The findings contribute to our comprehension of the antifungal mechanism of essential oils (EOs) and lay the groundwork for the creation of plant-derived antifungal medicines.
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Enhancing mechanical properties of Mg-Gd-Y-Zn alloys via microalloying with Ce and La
Zhaobin Zhang,Jonghyun Kim,Hongxin Liao,김기범,최태집,이태경,FuSheng Pan 대한금속·재료학회 2022 대한금속·재료학회지 Vol.60 No.9
This study investigated the microstructure and mechanical properties of Mg-1Gd-1Y-1Zn (at.%) alloys containing designed amounts of Ce or La. The Mg5(Gd,Zn) phase formed in the as-cast Mg-Gd-Y-Zn- Ce/La alloys and disappeared after a homogenization treatment at 500°C for 24 h. The addition of Ce and La resulted in the formation of Ce(Mg,Zn)12 and La(Mg,Zn)12 phases, respectively. Except for that, the Ce or La addition had no significant effect on the morphology, volume fraction, and type of the long-period stacking ordered (LPSO) phases in the Mg-Gd-Y-Zn alloy. The grain size decreased with increasing microalloying content because the heavy Ce and La atoms impeded atomic migration across the boundaries. The solute drag effect led to the formation of the rare earth texture in the extruded Mg-Gd-Y-Zn-Ce/La alloys, whose extent decreased with increasing microalloying content. The mechanical strength was improved by the addition of Ce or La at the sacrifice of ductility. In particular, La exhibited a stronger reinforcement ability than Ce when it was added to the Mg-Gd-Y-Zn alloys. Among the investigated chemical compositions, the Mg-1Gd-1Y-1Zn- 0.3La alloy exhibited the highest strength because it had the finest grains, the highest volume fraction of the second phase, and the weakest texture intensity. Furthermore, the alloys showed an unusual yield asymmetry due to the difference in the deformation mode of the LPSO phase.
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Ke Wang,Chao Sun,Povilas Dumčius,Hongxin Zhang,Hanlin Liao,Zhenlin Wu,Liangfei Tian,Wang Peng,Yongqing Fu,Jun Wei,Meng Cai,Yi Zhong,Xiaoyu Li,Xin Yang,Min Cui 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Blood–brain barrier (BBB) is a crucial but dynamic structure that functions as a gatekeeper for the central nervous system (CNS). Managing sufficient substances across the BBB is a major challenge, especially in the development of therapeutics for CNS disorders. Methods To achieve an efficient, fast and safe strategy for BBB opening, an acoustofluidic transwell (AFT) was developed for reversible disruption of the BBB. The proposed AFT was consisted of a transwell insert where the BBB model was established, and a surface acoustic wave (SAW) transducer realized using open-source electronics based on printed circuit board techniques. Results In the AFT device, the SAW produced acousto-mechanical stimulations to the BBB model resulting in decreased transendothelial electrical resistance in a dose dependent manner, indicating the disruption of the BBB. Moreover, SAW stimulation enhanced transendothelial permeability to sodium fluorescein and FITC-dextran with various molecular weight in the AFT device. Further study indicated BBB opening was mainly attributed to the apparent stretching of intercellular spaces. An in vivo study using a zebrafish model demonstrated SAW exposure promoted penetration of sodium fluorescein to the CNS. Conclusions In summary, AFT effectively disrupts the BBB under the SAW stimulation, which is promising as a new drug delivery methodology for neurodegenerative diseases.
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