Efficacy and safety of herbal medicine (Binafuxi granules) for the common cold with fever: A multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

Liu Xuemei,Min Jie,She Bin,Chen Yang,Li Jun,Huang Lei,Chen Ju,Luo Ai,Mei Yang,Li Ting,Wu Yanqing,Chen Daohong,Hongli Zhong,Liu Wei,Mao Bing,Jiang Hongli 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3

Background: Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking. Methods: In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment. Results: A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (P = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (P = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (P = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found. Conclusions: Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.

Designing an atmosphere controlling hollow fiber membrane system for mango preservation

Hong Liu,Linxiang Fu,Huan Liu,Caili Zhang,Bing Cao,Pei Li 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.7

We devised an atmosphere controlling facility to gain a longer life span for mango. A membrane module made of polyethersulfone/polydimethylsiloxane (PES/PDMS) composite membrane was applied to selectively permeate CO2 from the gas mixture of the fruit container. To design the membrane separation system, two models were introduced into our mathematical simulations: (1) an equilibrium model giving the optimal membrane area, the compositions of CO2 and O2 in the fruit container, feed flow rate and pressures on both the feed and permeate sides of the module, and (2) a dynamic model simulating the change in the gas composition of the fruit container with time. The pressure build-up in the bore side of the hollow fiber was also discussed using the Hagen-Poiseuille equation. The best membrane module configuration was obtained based on the pressure build-up analysis. That was (1) the vacuum pressure should be set at 0.1 bar, (2) the hollow fiber inner diameter should be 0.45mm, and (3) the vacuum should be applied at both ends of the hollow fiber bore sides.

Steel Bridge Construction of Hong Kong–Zhuhai–Macao Bridge

Wen-bo Gao,Quan-ke Su,Jin-wen Zhang,Hong-bing Xie,Feng Wen,Fang Li,Ji-zhu Liu 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.5

The 55-km-long Hong Kong–Zhuhai–Macao Bridge (HZMB) is the world’s longest sea-crossing bridge, connecting Hong Kong with Zhuhai and Macao at the mouth of the Pearl River Estuary in China, comprising 22.9-km-long steel bridges. HZMB is the leading steel bridge in China, with top-level manufacturing and installation technology. This paper outlines the steel bridge construction experiences of HZMB to provide comparisons for the construction of other long sea-crossing steel bridges at home or abroad. The main considerations of construction constraints, scheme selection, structural and aesthetic design of HZMB are presented, and the following points related to new strategies in the steel bridge construction of HZMB are elaborated: (1) construction quality assurance, (2) automatic manufacturing technology, (3) large segment off shore installation, (4) eco-friendly paint (content limitation of volatile organic compounds) and new multifunctional inspection gantry, and (5) Guss Mastic Asphalt steel deck pavement system. The successful implementation of those strategies shows that the steel bridge construction of HZMB promotes improvement in the overall construction and management level of the Chinese bridge industry. The advanced experience of HZMB has opened up broad prospects for the design and construction of off shore bridge engineering in China.

Chemotherapy and Late Course Three Dimensional Conformal Radiotherapy for Treatment of Patients with Stage III Non-small Cell Lung Cancer

Liu, Yang-Chen,Zhou, Shao-Bing,Gao, Fei,Ye, Hong-Xun,Zhao, Ying,Yi, Xiao-Xiang,Huang, Xin-En,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Objective: To compare the efficacy and complications of chemotherapy and late course three-dimensional conformal radiotherapy (3DCRT) in treating patients with stage III non-small cell lung cancer (NSCLC). Patients and Methods: All patients were divided into two groups: to receive chemotherapy and late course 3DCRT (3DCRT group), or chemotherapy and conventional fraction radiation (control group). In the 3DCRT-group, patients were given 6~15 MV X-rays with a total dose of 40 Gy, followed by 3DCRT, 2.5 Gy~3.0 Gy per fraction, 1 fraction/every day, total 68 Gy~70 Gy; in the control group, with conventional fraction radiation the total dose was 64~66 Gy. The chemotherapy regimen in both cases was EP (VP-16 and DDP). Results: Sixty four patients with stage III NSCLC were divided into two groups: 32 patients into 3DCRT, 32 into the control group. One and 2-year survival rates in 3DCRT and control group were 87.5%, 56.3%mad 65.6%, 34.4%, respectively (P<0.05); local control rates were 90.6%, 81.3% and 65.6%, 53.1%, respectively (P<0.05). Conclusion: Chemotherapy and late course 3DCRT is associated with improved survival rate in patients with stage III NSCLC with good tolerability.

Ginsenoside Re Increases Fertile and Asthenozoospermic Infertile Human Sperm Motility by Induction of Nitric Oxide Synthase

Hong Zhang,Qing-Ming Zhou,Xiao-Da Li,Yi Xie,Xin Duan,Feng-Ling Min,Bing Liu,Zhi-Gang Yuan 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.2

We investigated the effects of Ginsenoside Re on human sperm motility in fertile and asthenozoospermic infertile individuals in vitro and the mechanism by which the Ginsenosides play their roles. The semen samples were obtained from 10 fertile volunteers and 10 asthenozoospermic infertile patients. Spermatozoa were separated by Percoll and incubated with 0, 1, 10 or 100 µM of Ginsenoside Re. Total sperm motility and progressive motility were measured by computer-aided sperm analyzer (CASA). Nitric oxide synthase (NOS) activity was determined by the 3H-arginine to 3H-citrulline conversion assay, and the NOS protein was examined by the Western blot analysis. The production of sperm nitric oxide (NO) was detected using the Griess reaction. The results showed that Ginsenoside Re significantly enhanced both fertile and infertile sperm motility, NOS activity and NO production in a concentration-dependent manner. Sodium nitroprusside (SNP, 100 nM), a NO donor, mimicked the effects of Ginsenoside Re. And pretreatment with a NOS inhibitor Nω-Nitro-L-arginine methyl ester (L-NAME, 100 µM) or a NO scavenger N-Acetyl-L-cysteine (LNAC, 1 mM) completely blocked the effects of Ginsenoside Re. Data suggested that Ginsenoside Re is beneficial to sperm motility, and that induction of NOS to increase NO production may be involved in this benefit.

Schistosomiasis Combined with Colorectal Carcinoma Diagnosed Based on Endoscopic Findings and Clinicopathological Characteristics: A Report on 32 Cases

Liu, Wei,Zeng, Hong-Ze,Wang, Qi-Ming,Yi, Hang,Mou, Yi,Wu, Chun-Cheng,Hu, Bing,Tang, Cheng-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Aims and Background: To improve understanding of the relationship between schistosome-related enteropathy and colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics of colonic schistosomiasis. Materials and Methods: All cases of intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179 cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected for analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics were retrospectively evaluated. Results: Of the 179 colonic schistosomiasis patients, 32 combined with colorectal cancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classified as 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%), and 3 IIc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19 patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 welldifferentiated adenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma. The pathological findings suggest colorectal malignancy with deposited schistosome ova. Conclusions: Chronic schistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.

Solution Method and Application Verification of the K-curve as a Highway Transition Curve

Bing-hong Pan,Changpeng Wen,Kaiming Wang,Changjiang Liu,Linqi Chen 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7

Because of the singular form and low flexibility of the clothoid as a highway transition curve in highway horizontal alignment, the K-curve, whose ratio of the chord-tangent angle to the tangential angle at any point is fixed, was proposed in a previous work, including the corresponding parametric equations and basic characteristics, and its high flexibility and various shapes were proved. Here, the application and verification of the K-curve in highway alignment is further studied. The solution methods of the K-curve for different connections are given. Through theoretical calculations and specific real-world examples, the geometric positions and lateral forces of the K-curve and the clothoid under different connection conditions are compared. The results show that the difference between the K-curve and clothoid in the above two aspects under a straight line-to-circle connection is greater than that under a circle-to-circle connection as an egg curve, and although the lateral force coefficient of the K-curve is smaller than that of the clothoid, the K-curve suffers from rapid change in the lateral force coefficient and a higher lateral acceleration change rate. Finally, the application conditions of the K-curve for highway alignment design are given with consideration of the centrifugal acceleration change rate.

A SINGLE-CHIP-COMPUTER-BASED SEISMIC RECORDER

Liu Gua Kun,Pang Bing,Jiang Fa Qi,Xia Hong 대한전자공학회 1992 대한전자공학회 Conference Vol.1992 No.2

Structure and Properties of Polyimide (BTDA-TDI/MDI co-polyimide) Fibers Obtained by Wet-Spinning

Hong Bing Xiang,Zhong Huang,Li Qi Liu,Lei Chen,Jing Zhu,Zu Ming Hu,Jun Rong Yu 한국고분자학회 2011 Macromolecular Research Vol.19 No.7

BTDA-TDI/MDI (P84, synthesized by the condensation of 2,4-diisocyanato-1-methylbenzene and 1,1' -methylenebis(4-isocyanatobenzene) with 5,5'-carbonylbis(l,3-isobenzofurandione)) co-polyimide fibers were prepared by wet-spinning. The basic spinning conditions were found from the studies of dope viscosity, ternary phase diagrams, coagulation value, and precipitation value. The effect of the coagulation bath composition on the morphology of as-spun fibers was investigated and a theoretical approach was used to understand the coagulation phenomena. Scanning electron microscopy (SEM) showed that the cross-sectional shape of the fiber deviated more from an ellipse shape with the increasement of N-methyl-2-pyrrdidinone (NMP) content. The surface and cross section morphology of the as-spun fibers was also analyzed by the rate of diffusion and phase separation. The as-spun fibers were treated in heating tubes without drawing at different temperatures. The gravimetric analysis spectra showed that the BTDA-TDI/MDI co-polyimide fibers, which had been heat treated at 350 and 400 ℃, possessed better thermal properties than the as-spun fibers, a large weight loss was observed only above 550 ℃. Heat treatment of the fibers resulted in relatively high tensile strength and modulus. The fibers spun in Bath C (70/30, NMP/water, wt/wt)and Bath D (80/20, NMP/water, wt/wt) showed better thermal properties and higher tensile strength.

Hydrothermal Synthesis, Structure and Fluorescence of a New Triazole-bridging Zinc(II) 2D Layered Framework

Bing Liu,Yong-Hong Chen 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.12