Correlates of Lymphedema in Women with Breast Cancer: a Case Control Study in Shiraz, Southern Iran

Honarvar, Behnam,Sayar, Negin,Tahmasebi, Sedigheh,Zakeri, Zeinab,Talei, Asra,Rostami, Sara,Khademi, Sahar,Sarvestani, Amene Sabzi,Sekhavati, Eghbal Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Globally, the burden of breast cancer (BC) continues to increase. BC related lymphedema (BCRL) is currently non curable and as a life time risk it affects at least 25% of BC patients. Knowing more about BCRL and appropriate control of its modifiable risk factors can improve quality of life (QOL) of the affected patients. In this case control study to detect factors, 400 women with BCRL (as the case group) and 283 patients with BC without lymphedema (as the control group) that were referred to Shiraz University of Medical Sciences affiliated BC clinic center were assessed. The data were analyzed in SPSS. The mean age of the case group was $52.3{\pm}11.0years$ and of the control group was $50.1{\pm}10.9years$. In patients with BCRL, 203(50.7%) had left (Lt) side BC and in non- lymphedema group 151 (53.3%) had Lt side BC. Out of all BCRL patients, 204 (51%) had lymphedema in all parts of their affected upper extremities, 100 (25%) had swelling in the arm and forearm and 23 (5.7%) had edema in both the upper extremity and trunk. Edema, heaviness, concern about changing body image, pain and paresthesia were the most common signs/symptoms among patients with BCRL. In BCRL patients, the difference of circumference between the affected upper limb and non-affected limb was $4.4{\pm}2.5cm$ and the difference in volume displacement was $528.7{\pm}374.4milliliters$. Multiple variable analysis showed that moderate to severe activity (OR; odds ratio =14, 95% CI :2.6-73.3), invasiveness of BC (OR =13.7, 95% CI :7.3-25.6), modified radical mastectomy (OR=4.3, 95% CI :2.3-7.9), BMI =>25 (OR=4.2, 95% CI :2-8.7), radiotherapy (OR=3.9, 95% CI :1.8-8.2), past history of limb damage (OR=1.7, 95% CI :0.9-3.1) and the number of excised lymph nodes (OR=1.06, 95% CI :1.02-1.09) were the significant predictors of lymphedema in women with BC. Modifiable risk factors of BCRL such as non-guided moderate to severe physical activity, high BMI and trauma to the limb should be controlled as early as possible in BC patients to prevent development of BCRL and improve QOL of these patients.

The Impact of Abuse on the Quality of Life of the Elderly: A Population-based Survey in Iran

Honarvar, Behnam,Gheibi, Zahra,Asadollahi, Abdolrahim,Bahadori, Farzaneh,Khaksar, Elahe,Faradonbeh, Maryam Rabiey,Farjami, Mohammad The Korean Society for Preventive Medicine 2020 Journal of Preventive Medicine and Public Health Vol.53 No.2

Objectives: The quality of life (QoL) of the elderly and elder abuse are growing public health concerns. This study aimed to evaluate the prevalence of abuse and the association between QoL and abuse in older adults. Methods: Multistage random cluster sampling, along with valid QoL (LEIPAD: LEIden, the Netherlands; PADua, Italy; Helsinki, Finland) and abuse questionnaires, were used to assess QoL and elder abuse. Path analysis was performed using Mplus. SPSS and AMOS were used for the other analyses. Results: A total of 386 elderly individuals with a mean age of 68.00±6.10 years were interviewed, of whom 200 (51.8%), 289 (74.9%), and 376 (97.4%) were women, educated, and married, respectively. Moreover, 167 (43.2%) had low-to-moderate QoL, and 108 (27.9%) had experienced a moderate level of abuse. QoL and abuse were inversely associated (r=-0.253), with men (β=-0.24) more affected than women (β=-0.21). Musculoskeletal disorders were also strong determinants of QoL in the elderly. QoL was strongly associated with emotional abuse, while abuse was highly related to the social component of QoL. Furthermore, emotional abuse was the type of abuse most significantly associated with the self-care, depression/anxiety, cognitive, and social components of QoL. Sexual abuse, violation of personal rights, and neglect were the main determinants of the physical functioning, life satisfaction, and sexual domains of QoL, respectively. Conclusions: Nearly half of the elderly individuals lacked a high QoL, and at least one-fourth had experienced some form of abuse. Elder abuse was correlated inversely with QoL. Therefore, preventive interventions are recommended to decrease elder abuse in the family, community, and other settings.

Survey of a New Note on Karnaugh Maps

Barmak Honarvar Shakibaei Asli 보안공학연구지원센터 2012 International Journal of Control and Automation Vol.5 No.2

Ovarian Malignancy Probability Score (OMPS) for Appropriate Referral of Adnexal Masses

Arab, Maliheh,Honarvar, Zahra,Hosseini-Zijoud, Seyed-Mostafa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: Ovarian cancer is the most common cancer cause of gynecologic cancer deaths. In order to increase the likelihood of patient survival through primary operation by gyneco-oncologists, an appropriate algorithm for referral is considered here. Materials and Methods: Suspicious adnexal mass cases including ovarian malignancy probability score-1 (OMPS1) scores between 2.3-3.65 are re-evaluated by OMPS2. Sensitivity and specificity of each score were determined. Results: Sensitivity and specificity with a 3.82 score of OMPS2 in the studied subgroup (OMPS1 scores between 2.3-3.65) were 64% and 76.9% respectively. Conclusions: Management of OMPS1 scores of below 2.3 with sensitivity of 100% and above 3.65 with specificity of 72.9% is clear. In the subgroup of cases with OMPS1 score between 2.3-3.65, OMPS2 is helpful for triage with a cutoff score of 3.82.

Finite element modeling of laser ultrasonics nondestructive evaluation technique in ablation regime

Salman Shamsaei,Farhang Honarvar Techno-Press 2023 Advances in computational design Vol.8 No.3

In this paper, finite element modeling of the laser ultrasonics (LU) process in ablation regime is of interest. The momentum resulting from the removal of material from the specimen surface by the laser beam radiation in ablation regime is modeled as a pressure pulse. To model this pressure pulse, two equations are required: one for the spatial distribution and one for the temporal distribution of the pulse. Previous researchers have proposed various equations for the spatial and temporal distributions of the pressure pulse in different laser applications. All available equations are examined and the best combination of the temporal and spatial distributions of the pressure pulse that provides the most accurate results is identified. This combination of temporal and spatial distributions has never been used for modeling laser ultrasonics before. Then by using this new model, the effects of variations in pulse duration and laser spot radius on the shape, amplitude, and frequency spectrum of ultrasonic waves are studied. Furthermore, the LU in thermoelastic regime is simulated by this model and compared with LU in ablation regime. The interaction of ultrasonic waves with a defect is also investigated in the LU process in ablation regime. Good agreement of the results obtained from the new finite element model and available experimental data confirms the accuracy of the proposed model.

RESEARCH : Open Access ; Comparison of three boosting methods in parent-offspring trios for genotype imputation using simulation study

( Abbas Mikhchi ),( Mahmood Honarvar ),( Nasser Emam Jomeh Kashan ),( Saeed Zerehdaran ),( Mehdi Aminafshar ) 한국동물자원과학회(구 한국축산학회) 2016 한국축산학회지 Vol.58 No.1

Background: Genotype imputation is an important process of predicting unknown genotypes, which uses reference population with dense genotypes to predict missing genotypes for both human and animal genetic variations at a low cost. Machine learning methods specially boosting methods have been used in genetic studies to explore the underlying genetic profile of disease and build models capable of predicting missing values of a marker. Methods: In this study strategies and factors affecting the imputation accuracy of parent-offspring trios compared from lower-density SNP panels (5 K) to high density (10 K) SNP panel using three different Boosting methods namely TotalBoost (TB), LogitBoost (LB) and AdaBoost (AB). The methods employed using simulated data to impute the un-typed SNPs in parent-offspring trios. Four different datasets of G1 (100 trios with 5 k SNPs), G2 (100 trios with 10 k SNPs), G3 (500 trios with 5 k SNPs), and G4 (500 trio with 10 k SNPs) were simulated. In four datasets all parents were genotyped completely, and offspring genotyped with a lower density panel. Results: Comparison of the three methods for imputation showed that the LB outperformed AB and TB for imputation accuracy. The time of computation were different between methods. The AB was the fastest algorithm. The higher SNP densities resulted the increase of the accuracy of imputation. Larger trios (i.e. 500) was better for performance of LB and TB. Conclusions: The conclusion is that the three methods do well in terms of imputation accuracy also the dense chip is recommended for imputation of parent-offspring trios.

Experimental Investigation on Finasteride Microparticles Formation via Gas Antisolvent Process

( Mohammad Najafi ),( Nadia Esfandiari ),( Bizhan Honarvar ),( Zahra Arab Aboosadi ) 한국화학공학회 2021 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.59 No.3

Micro and nanoparticles of Finasteride were prepared by gas-antisolvent method. The influence of process parameters such as pressure (100, 130 and 160 bar), temperature (308, 318 and 328 K) and solute concentrations (10, 25 and 40 mg/ml) on mean particle size was studied by Box-Behnken design. As ANOVA results indicated, the highest influence in production of smaller particles was attributed to the pressure. Optimum condition leading to the smallest particle size was as follows: initial solute concentration, 10 mg/ml; temperature, 308 K and pressure, 160 bar. The particles were evaluated with FTIR, SEM, DLS, XRD as well as DSC. The analyses revealed a size decrease in the precipitated Finasteride particles (232.4 nm, on mean) via gas-antisolvent method, as compared to the original particles (55.6 μm).

Optimization of vitamin B12 nano-emulsification and encapsulation using spontaneous emulsification

Shabnam Karbalaei-Saleh,Shima Yousefi,Masoud Honarvar 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.2

In this study, the use of low-energy methods for nanoemulsification of vitamin B12 was investigated to protect this bioactive substance. The effects of sunflower oil concentrations (4–8%), Tween 80 (8–16%), and vitamin B12 (5–15%) on the physicochemical properties of B12 nanoemulsion were evaluated using response surface methodology (RSM). The results indicated that the quadratic model was the most fitting model for experimental data. Optimization revealed that the optimal formulation contained 6.5% sunflower oil, 9.6% Tween 80, and 13% vitamin B12, resulting in maximum efficiency, viscosity, and vitamin B12 content, as well as minimum pH, turbidity, p-Anisidine index, particle size, and polydispersity index (PDI). Under optimal conditions, pH, viscosity, turbidity, efficiency, vitamin B12, p-Anisidine index, PDI, and particle size were 7.24, 17.0024 cp, 2.19, 51.98%, 5.54 ppm, 0.01, 0.34, and 322 nm, respectively. This study highlights the effectiveness of spontaneous emulsification as a carrier for the encapsulation of bioactive compounds.

Effect of Cu-MOFs incorporation on gas separation of Pebax thin film nanocomposite (TFN) membrane

Mahdi Fakoori,Amin Azdarpour,Reza Abedini,Bizhan Honarvar 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.1

MOF-based membranes, which have appropriate MOF dispersion and suitable interaction, have shown high CO2 permeability and significant CO2/CH4 and CO2/N2 selectivity. In this study, a layer of Pebax was coated on polysulfone (PSF), which this layer incorporated by various content of Cu-MOFs to improve the performance (permeability and CO2/CH4 and CO2/N2 selectivity) of all membranes. Characterization techniques such as SEM, TGA, BET, and gas adsorption verified that Cu-BTC was successfully dispersed into the Pebax matrix. Pure CO2 and CH4 gases permeation experiments were performed to investigate the impact of Cu-MOFs on the gas permeability of prepared MOF-based membranes. The “Pebax” embedded by 15 wt% CuBTC and 15 wt% of NH2-CuBTC over PSF support exhibited higher gas separation performance compared to the pristine one. They demonstrated a CO2 permeability of 228.6 and 258.3 Barrer, respectively, while the blank membrane had a CO2 permeability of 110.6 Barrer. Embedding the NH2-Cu-BTC intensified the interaction between incorporated MOF particles and the polymer phase that led to increase the CO2/CH4 and CO2/N2 selectivity. In addition, the performance of prepared membranes was evaluated at various feed pressures with the range of 2-10 bar. The CO2/CH4 and CO2/N2 separation was enhanced as the feed pressure surged.

Knitted Fabric Relaxation by Ultrasound and Its Characterization with Yarn-pullout Force

Jeddi, Ali A. A.,Mohammadi, V.,Rahimzadeh, H.,Honarvar, F. The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.4

An investigation on the dimensional properties of plain knitted fabric produced from cotton yarn and subjected to different relaxation treatments is presented in this paper. The main aim of this research is to characterize the internal energy of fabric by using yarn-pullout test method in ultrasonic relaxation state and compare it with other common mechanical relaxation treatments. A comprehensive experimental analysis showed that, by using ultrasonic waves, the area geometry constant value $(k_s)$ achieved was higher than the conventional relaxation methods. Then, we introduced residual-energy forming and loss-energy uniforming. The former appeared due to fabric shrinkage and the later one appeared due to release of fabric loops from extra forces which imposed during knitting process. The results also indicated that ultrasonic waves energy causes more uniformity on loop and consequently, the fabric reaches to a less internal energy than washing treatment.