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문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.
Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury
Lee, Eun-Mi,Lee, Young-Eun,Lee, Esder,Ryu, Gyeong Ryul,Ko, Seung-Hyun,Moon, Sung-Dae,Song, Ki-Ho,Ahn, Yu-Bae Korean Diabetes Association 2011 Diabetes and Metabolism Journal Vol.35 No.5
<P><B>Background</B></P><P>Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic β-cells. Heme oxygenase-1 (HO-1) has been identified as an anti-apoptotic and cytoprotective gene. The purpose of this study is to investigate whether HO-1 up-regulation when using metalloprotophyrin (cobalt protoporphyrin, CoPP) could protect pancreatic β-cells from high glucose-induced apoptosis.</P><P><B>Methods</B></P><P>Reverse transcription-polymerase chain reaction was performed to analyze the CoPP-induced mRNA expression of HO-1. Cell viability of INS-1 cells cultured in the presence of CoPP was examined by acridine orange/propidium iodide staining. The generation of intracellular reactive oxygen species (ROS) was measured using flow cytometry. Glucose stimulated insulin secretion (GSIS) was determined following incubation with CoPP in different glucose concentrations.</P><P><B>Results</B></P><P>CoPP increased HO-1 mRNA expression in both a dose- and time-dependent manner. Overexpression of HO-1 inhibited caspase-3, and the number of dead cells in the presence of CoPP was significantly decreased when exposed to high glucose conditions (HG). CoPP also decreased the generation of intracellular ROS by 50% during 72 hours of culture with HG. However, decreased GSIS was not recovered even in the presence of CoPP.</P><P><B>Conclusion</B></P><P>Our data suggest that CoPP-induced HO-1 up-regulation results in protection from high glucose-induced apoptosis in INS-1 cells; however, glucose stimulated insulin secretion is not restored.</P>
The Significant Decisions in Cold Chain Logistics
Sung-Ho RYU(Sung-Ho RYU) 동아시아경상학회 2023 The East Asian Journal of Business Economics Vol.11 No.1
Purpose – The prior literature has shown that there is a lack of a complete assessment of the key decisions in cold chain logistics. Such a study is required to offer recommendations for research in this expanding but underresearched topic with potentially significant management ramifications. Research design, Data, and methodology – The current researcher accumulated peer-reviewed sources from databases to augment each chosen study's validity. Selection varied between seminal works and much of the existing literature. The selection process was consistent with using a content checklist that established the inclusion and exclusion criteria. Result – The research findings indicate total five solutions regarding better decision in Cold Chain Logistics (CCL), such as (1) Pricing Decision in Cold Chain Logistics, (2) Decision on Temperature Control Decision in Cold Chain Logistics, (3) Supply Chain Network Design in Cold Chain Logistics, (4) Decision on Minimizing Inventory in Cold Chain Logistics, (5) Decision on Logistics Distribution. Conclusion – Stability of a cold chain should be maintained from manufacture or via logistical components and cold logistics products are susceptible to several variables, such as temperature, and degradation can easily harm food supply, product prices, and human health. Product safety infractions substantially impact human health, among other losses linked with a functioning CCL.
Comparative Morphological Characteristics of Mangrove Oysters
Yoo, Sung Kyoo,Ryu, Ho Young 한국수산학회 1984 한국수산과학회지 Vol.17 No.3
Three Kinds of mangrove oysters, highly commercial species in tropical waters, were collected in Cocineta Bay, Venezuella in 1976, at the mouth of Hoffman River, Liberia in 1978 and in West Coast of Benzina, Indonesia in 1984. Crassostrea rhizophorae from Venezuella showed some characteristics of most rounded shell form and greatest shell capacity. In addition, he fatness condition of 9.63% topped tht other two species. Crassostrea tulipa inhabiting Liberia was most elongated in outer shell form. Although shell capacity of this species was almost similar to Crassostrea rhizophorae, it took up intermediate position in fatness condition with 8.15%. Crassostrea belcheri from Indonesia, just rounded like C. rhizophorae, showed the biggest values in total weight and outer shell weight but fatness the least with 6.62%
Ryu, Seung-Yeob,Ko, Sung-Ho Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.6
The volume of fluid (VOF) model of FLUENT and the lattice Boltzmann method (LBM) are used to simulate two-phase flows. Both methods are validated for static and dynamic bubble test cases and then compared to experimental results. The VOF method does not reduce the spurious currents of the static droplet test and does not satisfy the Laplace law for small droplets at the acceptable level, as compared with the LBM. For single bubble flows, simulations are executed for various Eotvos numbers, Morton numbers and Reynolds numbers, and the results of both methods agree well with the experiments in the case of low Eotvos numbers. For high Eotvos numbers, the VOF results deviated from the experiments. For multiple bubbles, the bubble flow characteristics are related by the wake of the leading bubble. The coaxial and oblique coalescence of the bubbles are simulated successfully and the subsequent results are presented. In conclusion, the LBM performs better than the VOF method.