ORiginal Article : Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats

( Yoon Jeong Choi ),( Nayoung Kim ),( Ju Yup Lee ),( Ryoung Hee Nam ),( Ji Hyung Seo ),( Seonmin Lee ),( Hee Jin Kim ),( Yoon Jin Choi ),( Hye Seung Lee ),( Dong Ho Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.3

Background/Aims: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-Lcysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. Methods: Sprague- Dawley rats were divided into six groups, including a nonethanol group, groups treated with absolute ethanol 1 hour after pretreatment with various doses of PMK-S005 (1, 5, and 10 mg/kg) or rebamipide (50 mg/kg), and an absolute ethanolonly group. Ethanol-induced gross ulcer and mucus levels were measured. Myeloperoxidase, tumor necrosis factor a, interleukin 1β, PGE2, LTB4, cPLA2, COX-1, and COX-2 levels were estimated by enzyme-linked immunosorbent assay or Western blot analysis. Furthermore, the protein expression levels of antioxidant enzymes, including heme oxygenase-1 (HO-1), NAD(P)H:quinine oxidoreductase 1 (NQO-1), GCLC, and GCLM, were assessed. Results: PMK-S005 significantly attenuated the ethanol-induced gastric damage; it reduced mucosal inflammatory cytokine production and increased mucus levels. The expression levels of cPLA2, COX-1, and COX-2 were decreased by PMK-S005. PMK-S005 did not affect PGE2 synthesis, but LTB4 production was significantly suppressed. In addition, long-term administration of PMKS005 significantly increased the expression of HO-1, NQO-1, GCLC, and GCLM. Conclusions: These results strongly suggest that PMK-S005 prevents gastric mucosal damage and that these gastroprotective activities are due to anti-inflammatory effects and enhancement of the gastric defense system, including antioxidant enzymes. (Gut Liver 2016;10:348- 355)

운동경력과 기능수준이 복싱선수의 경쟁불안에 미치는 영향

김진표,백호룡 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.15 No.1

This study was made to provide boxing players with fundamental references for their performance enhancement, based on the research out of Yong In university boxing team, of which 30 players had been chosen, to find out the correlated performance reinforcement and enhancement right before their competitions(5 days before, 3 days before, 30 minutes before) with their years of boxing career(less than 4 years, 5 or 6 years, more than 7 years) and with their performance levels(superior level, inferior level). Analysing tool to verify the hypothesis of this study was the sports' competition analysis inspection method(CSAI-2) with the statistic program(SPSS) utilized and the repeated variance method was taken to get the degree of instability by the performance careers, the performance levels and the left times before competition. The repeated methode was applied to verify the results with the statistical difference allowed by 5%. Conclusions resulted from the above mentioned research are as follows; 1. In terms with the players' technical performance level, the inferior players had more cognitional anxiety than the superior players with some statistically significant difference. 2. In terms with the players' physical instability, the inferior players had more anxiety than the superior players with no statistically significant difference. 3. In terms with the players' technical performance level, the superior players had more self-confidence than the inferior players with no statistically significant difference. 4. In terms with the years of experience, cognitional anxiety was found most severely among the college boxing players of less than 4 years' career with some statistically significant difference. 5. In terms with the years of experience, physical anxiety was found most severely among the college boxing players of less than 4 years' career with no statistically significant difference. 6. In terms with the years of experience, the highest self- confidence was found among the college boxing players of 5 or 6 years' career with no statistically significant difference.

Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice

Song, Chin-Hee,Kim, Nayoung,Lee, Sun Min,Nam, Ryoung Hee,Choi, Soo In,Kang, So Ra,Shin, Eun,Lee, Dong Ho,Lee, Ha-Na,Surh, Young-Joon Elsevier 2019 Biochemical pharmacology Vol.164 No.-

<P><B>Abstract</B></P> <P>Estrogen is known to have a protective effect in colorectal cancer (CRC) development. Previously, we reported the anti-inflammatory and antitumorigenic effects of 17β-estradiol (E2) in azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated male mice. The aim of this study was to investigate whether ovariectomy in a female AOM/DSS mouse model increases colorectal tumorigenesis and whether tumorigenesis is reduced by estrogen supplementation after ovariectomy. Clinical symptoms and histological severity of colitis and the levels of inflammatory mediators were evaluated in the colon of AOM/DSS-treated ovariectomized (OVX) mice. The levels of E2, myeloperoxidase (MPO), and NF-κB-dependent cytokines (interleukin (IL)-1β and IL-6) were measured by ELISA. Furthermore, quantitative real-time (qRT) PCR and Western blot analysis were performed. Ovariectomy did not aggravate AOM/DSS-induced colitis at 2 weeks. At weeks 10 and 16, ovariectomy significantly increased tumor number and incidence rate in only the proximal colon after AOM/DSS treatment (F_AOM/DSS vs OVX_AOM/DSS), and these increases were significantly reduced by E2 supplementation (OVX_AOM/DSS vs OVX_AOM/DSS/E2). However, ovariectomy did not affect CRC development in the distal colon (F_AOM/DSS vs OVX_AOM/DSS). At week 2, E2 administration to AOM/DSS-treated OVX mice attenuated the histological severity of colitis by decreasing the protein and/or mRNA levels of estrogen receptor alpha (ERα) and NF-κB-related mediators (i.e., COX-2, TNF-α, and IL-6) and by enhancing estrogen receptor beta (ERβ) and nuclear Nrf2 protein expression and the mRNA expression of related antioxidant enzyme genes (i.e., HO-1, GCLC, GCLM, and NQO1). Endogenous estrogen in females protects against the development of proximal colon cancer, and exogenous E2 replacement in OVX female mice showed protective effects against AOM/DSS-induced colitis and carcinogenesis. The mechanism could involve modulating ERs-, NF-κB- and Nrf2-mediated pathways.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Modified Atmosphere Packaging of Precut and Prepared Vegetables

Ho Ryoung Kwon,Dong Sun Lee 한국식품과학회 1995 Food Science and Biotechnology Vol.4 No.3

Respiration Characteristics of Five Korean Fresh Vegetables

Ho Ryoung Kwon,Dong Sun Lee 한국식품과학회 1994 Food Science and Biotechnology Vol.3 No.4

다차원적인 북핵 해법

이호령(Ho-ryoung Lee) 한국캐나다학회 2004 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.10 No.-

Thin Film (La_0.7Sr_0.3)_0.95MnO_3-δ Fabricated by Pulsed Laser Deposition and Its Application as a Solid Oxide Fuel Cell Cathode for Low-Temperature Operation

Noh, Ho-Sung,Son, Ji-Won,Lee, Heon,Kim, Hae-Ryoung,Lee, Jong-Ho,Lee, Hae-Weon The Korean Ceramic Society 2010 한국세라믹학회지 Vol.47 No.1

The feasibility of using the thin film technology in utilizing lanthanum strontium manganite (LSM) for a solid oxide fuel cell (SOFC) cathode in a low-temperature regime is investigated in this study. Thin film LSM cathodes were fabricated using pulsed laser deposition (PLD) on anode-supported SOFCs with yttria-stabilized zirconia (YSZ) electrolytes. Although cells with a 1 ${\mu}m$-thick LSM cathode showed poor low-temperature cell performance compared to that of a cell with a bulk-processed cathode due to the lack of a triple-phase boundary length, the cell with 200 nm-thick gadolinia-doped ceria (GDC) inserted between the LSM and YSZ showed enhanced performance and more stable operation characteristics in a comparison of a cell without a GDC layer. We postulate that the GDC layer likely improved the cathode adhesion, therefore contributing to the improvement of the cell performance instead of serving as an interfacial reaction buffer.

삼상유동층 공정에서 수력학적 Similarity 해석

임호 ( Ho Lim ),임현오 ( Hyun Oh Lim ),진해룡 ( Hae Ryoung Jin ),임대호 ( Dae Ho Lim ),강용 ( Yong Kang ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.6

삼상유동층에서 수력학적 유사성을 규모인자(scaling factor)를 이용하여 해석하였다. 규모인자는 직경이 다른 두 종류의 삼상유동층간의 기체, 액체, 그리고 고체입자의 체류량과 단위면적당 유효부피흐름속도를 기준으로 정의하였다. 두 종류 삼상유동층의 직경은 각각 0.102 m와 0.152 m이었다. 여과된 압축공기, 물 그리고 밀도가 2,500 kg/m3인 유리구슬을 각각 기체, 액체 그리고 유동고체입자로 사용하였다. 각 삼상유동층에서 각 상들의 체류량은 정압강하법에의해 결정하였다. 기체 및 액체의 유속 그리고 고체유동입자의 크기가 각 상들을 기준으로한 규모인자와 유효부피흐름 속도를 기준으로한 규모인자에 미치는 영향을 검토하였다. 직경이 다른 두 삼상유동층에서 기체 체류량의 편차는 기체와 액체의 유속이 증가함에 따라 감소하였으나 유동입자의 크기가 증가함에 따라 증가하였다. 직경이 다른 두 종류 삼상유동층에서 액체 체류량 편차는 기체와 액체 그리고 고체유동입자의 크기가 증가함에 따라 감소하였다. 두 종류 삼상유동층에서 고체입자 체류량 편차는 기체유속과 유동입자의 크기가 증가함에 따라 증가하였으나 액체의 유속이 증가함에 따라 감소하였다. 직경이 다른 두 종류 삼상유동층에서 유효부피흐름속도를 매개로 한 규모인자는 기체유속과 유동입자의 크기가 증가함에 따라 감소하였으나 액체의 유속이 증가함에 따라 증가하였다. 본 연구에서 정의된 규모인자는 삼상유동층 공정의 수력학적 유사성을 해석하는데 효과적으로 사용될 수 있었다. Hydrodynamic similarity was analyzed by employing scaling factor in three phase fluidized beds. The scaling factor was defined based on the holdups of gas, liquid and solid particles and effectivity volumetric flux of fluids between the two kinds of fluidized beds with different column diameter. The column diameter of one was 0.102 m and that of the other was 0.152 m. Filtered compressed air, tap water and glass bead of which density was 2,500 kg/m3 were used as gas, liquid and solid phases, respectively. The individual phase holdups in three phase fluidized beds were determined by means of static pressure drop method. Effects of gas and liquid velocities and particle size on the scaling factors based on the holdups of each phase and effective volumetric flux of fluids were examined. The deviation of gas holdup between the two kinds of three phase fluidized beds decreased with increasing gas or liquid velocity but increased with increasing fluidized particle size. The deviation of liquid holdup between the two fluidized beds decreased with increasing gas or liquid velocity or size of fluidized solid particles. The deviation of solid holdup between the two fluidized beds increased with increasing gas velocity or particle size, however, decreased with increasing liquid velocity. The deviation of effective volumetric flux of fluids between the two fluidized beds decreased with increasing gas velocity or particle size, but increased with increasing liquid velocity. The scaling factor, which was defined in this study, could be effectively used to analyze the hydrodynamic similarity in three phase fluidized processes.

‘Illusional’ nano-size effect due to artifacts of in-plane conductivity measurements of ultra-thin films

Kim, Hae-Ryoung,Kim, Jong-Cheol,Lee, Kyung-Ryul,Ji, Ho-Il,Lee, Hae-Weon,Lee, Jong-Ho,Son, Ji-Won The Royal Society of Chemistry 2011 Physical chemistry chemical physics Vol.13 No.13

<P>The nano-size effect, which indicates a drastic increase in conductivity in solid electrolyte materials of nano-scale microstructures, has drawn substantial attention in various research fields including in the field of solid oxidefuelcells (SOFCs). However, especially in the cases of the conductivity of ultra-thin films measured in an in-plane configuration, it is highly possible that the ‘apparent’ conductivity increase originates from electrical current flowing through other conduction paths than the thin film. As a systematic study to interrogate those measurement artifacts, we report various sources of electrical current leaks regarding in-plane conductivity measurements, specifically insulators in the measurement set-up. We have observed a ‘great conductivity increase’ up to an order of magnitude at a very thin thickness of a single layer yttria-stabilized zirconia (YSZ) film in a set-up with an intentional artifact current flow source. Here we propose that the nano-size effect, reported to appear in ultra-thin single layer YSZ, can be a result of misinterpretation.</P> <P>Graphic Abstract</P><P>‘Illusional’ high conductivity in nano-scale thin films due to measurement artifacts. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cp02673e'> </P>

토지대장/지적도 이력관리 시스템을 위한 시공간 연산자의 설계 및 구현

김성룡(Sung Ryoung Kim),김상호(Sang Ho Kim),이화종(Hwa Jong Lee),근호(Keun Ho Ryu) 대한공간정보학회 2000 한국공간정보시스템학회 논문지 Vol.2 No.2

GIS Tools is able to not only store the integrated information between attribute data and spatial data, but also analyze them. Most of GIS Tools support current information of land. However, lawsuit of right of possession as well as statistic of past data for land policy may need historical information. Therefore, in the paper, we designed the spatiotemporal operators what can handle the historical information, and implemented them. The spatiotemporal operators are used in the history management system of Cadastre and Cadastral map based on GIS. The historical information is generated in spatial operation of spatiotemporal operators and then the implemented operators provide a function to store the historical information, and handle them.