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Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield
Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5
A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.
높은 입체선택성을 나타내는 고리카보네이트의 친핵성 치환반응과 광학활성인 β-Hydroxy Ester의 합성
강석구,박동철,노호식,윤승현,홍덕표 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1
The nucleophilic ring opening of the cyclic carbonates of optically active threo-2,3-dihydroxy esters afforded α-substituted β-hydroxy esters with highly regio- and stereoselectivity under mild conditions. The α-substituted β-hydroxy esters were transformed to β-hydroxy esters
Flowable 및 microfill 복합레진으로 충전된 제 5급와동에서 load cycling 전,후의 미세변연누출 비교
강석호,김오영,오명환,조병훈,엄정문,권혁춘,손호현 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2
Low-viscosity composite resins may produce better sealed margins than stiffer compositions (KempScholte and Davidson, 1988; Crim, 1989). Flowable composites have been recommended for use in Class V cavities but it is also controversial because of its high rates of shrinkage. On the other hand, in the study comparing elastic moduli and leakage, the microfil had the least leakage (Rundle et al. 1997). Furthermore, in the 1996 survey of the Reality Editorial Team, microfills were the clear choice for abfraction lesions. The purpose of this study was to evaluate the microleakage of 6 composite resins (2 hybrids, 2 microfills, and 2 flowable composites) with and without load cycling. Notch-shaped Class V cavities were prepared on buccal surface of 180 extracted human upper premolars on cementum margin. The teeth were randomly divided into non-load cycling group (group 1) and load cycling group(group 2) of 90 teeth each. The experimental teeth of each group were randomly divided into 6 subgroups of 15 samples. All preparations were etched, and Single bond was applied. Preparations were restored with the following materials (n=15) : hybrid composite resin [Z250(3M Dental Products Inc. St.Paul, USA), Denfil(Vericom, Ahnyang, Korea)], microfil [Heliomolar RO(Vivadent, Schaan, Liechtenstein), Micronew(Bisco Inc. Schaumburg, IL, USA)], and flowable composite[AeliteFlo(Bisco Inc. Schaumburg, IL, USA), Revolution(Kerr Corp. Orange, CA, USA)]. Teeth of group 2 were subjected to occlusal load (100N for 50,000 cycles) using chewing simulator(MTS 858 Mini Bionix Ⅱ system, MTS Systems Corp., Minn, USA). All samples were coated with nail polish 1mm short of the restoration, placed in 2% methylene blue for 24 hours, and sectioned with a diamond wheel. Enamel and dentin/cementum margins were analyzed for microleakage on a sclale of 0 (no leakage) to 3 (3/3 of wall). Results were statistically analyzed by Kruskal-Wallis One way analysis, Mann-Whitney U-test, and Student-Newmann-Keuls method. (p=0.05) Results: 1. There was significantly less microleage in enamel margins than dentinal margins of all groups. (p<0.05) 2. There was no significant difference between six composite resin in enamel margin of group 1. 3. In dentin margin of group 1, flowable composite had more microleakage than others but not of significant differences. 4. There was no significant difference between six composite resin in enamel margin of group 2. 5. In dentin margin of group 2, the microleakage were R>A=H=M>D>Z. But there was no significant differences. 6. In enamel margins, load cycling did not affect the marginal microleakage in significant degree. 7. In dentin margins, load cycling did affect the marginal microleakage only in Revolution. (p<0.05)
강석구,조현성,이재호 성균관대학교 기초과학연구소 1989 論文集 Vol.40 No.2
천연물 합성에서 출발물질로 유용하게 쓰이는 디아세톤 글루코스 헥소퓨라노스고리의 산화와 입체선택적 변형에 관하여 연구하였다. 이 고리의 C-3위치에 있는 히드록시기를 Trifluoroacetic anhydride(TFAA)로 사용하여 케토기로 산화시키는 방법을 연구한 후 얻어진 C-3 위치에 케톤에 대해 Grignard반응과 Wittig반응을 도입하여 퓨라노스고리의 C-3위치에 입체 선택적으로 치환기를 유도하는 방법을 연구하였다. 또한 고리밖의 곁가지의 변형도 아울러 연구하였다. We have studied on the oxidation and the stereoselective modifications of the hexofuranose ring derived from diacetone glucose. We have attempted the method of the oxidation with trifluoroacetic anhydride (TFAA) on the C-3 position of this furanose ring. On the other hand, we have induced the stereoselective substrate on the keto group of the C-3 position. The modifications of the side chain out of the ring have been also studied.
강석구,이성호 성균관대학교 기초과학연구소 1990 論文集 Vol.41 No.1
(+)-Aspicilin은 Lecanora속에 속하는 lichen에서 분리된 거대고리락톤계 항생물질이다. 본 연구에서는 이를 비대칭적으로 합성하기 위해 두 부분의 합성 중간체인 벤질 5-데옥시-2, 3-0-이소프로필리덴-6-요드-α-D-만노시드와 (S)-(+)-9-데신-2-올을 각각 합성하였다. We have studied the synthesis of (+)-aspicilin, a macrolactonic substance which is isolated from a lichen source of the Black forest. As building blocks for enantiocontrolled synthesis of (+) -aspicilin, benzyl 5-deoxy-2. 3-0-isopropylidene-6-iodo-α-Dmannofuranoside and (S)-(+)-9-decyn-2-ol were synthesized.
갱신 효율을 위한 엘리먼트 ID 상속 기반의 XML 저장
강인석,권훈,김정희,곽호영 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2
In this thesis, ID inheritance storage system modelbase on XML document and information of schema element structure has proposed. proposed system parse XML document and read in DOM type then assign ID to element by using analysis module.at this time, ID assigned to child element is inherited from parent element ID and assigned ID will be saved to database as form of defined schema structure proposed for efficient search and updates of document. As results, when specific element has inserted or updated, location information are not required to configured again.
姜鎬祚,韓錫絃 건국대학교 1978 論文集 Vol.7 No.1
The nitrite content, VBN(volatile basic nitrogen) and bacterial count in pork sausage stored at various temperatures were examined for the evaluation hygienic condition of meat products. 1.Nitrite content of pork sausage was decreased from 3.1ppm to 2.2ppm in 25 days at 7℃, from 3.1ppm to 0.8ppm in 5 days at 25℃, and from 3.1ppm to 0.4ppm in 5 days at 36℃, respectively. 2.Nitrite content of pork sausage in which potassium nitrite was added was, however, increased from 3.1ppm to the maximum amounts of 15.2ppm, 118.3ppm and 97.6ppm when kept for 35 days at 7℃, 30 clays at 25℃ and 26 days at 36℃, respectively. 3.Content of VNB of pork sausage with potassium nitrate was increased from 11mg% to 40mg% after the storage for both 35 days at 7℃, 5 days at 25℃ and 5 days at 36℃. The bacterial counts of the pork sausage of 7˚, 25˚ and 36℃ groups were increased from 103 to 104,109 anti 109, respectively.
姜錫浩,宋希準,安熙官 嶺南大學校 工業技術硏究所 1978 연구보고 Vol.6 No.1
In order to study the flow characteristics of spherical glass-beads ranging from 40 mesh to-115 mesh, its angle of repose and angle of rupture were measured as a function of average particle size, addition of fine powder as glidant or lubricant, and admixture of 2 or 3 adjacent fractions of beads classified by screening. The angle of repose of the glass-beads increases with increasing particle size of above 100 mesh, but for beads smaller than 100 mesh, the angle of repose increases with decreasing particle size. Fine glidant of montmorcalite added to the beads in very small concentrations of 0.6wt, % decreases the flow angles, while it tends to increase strongly the flow angles at higher concentrations.