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이민걸,곽호,박주영,김세종,이정복 ( Min Geol Lee,Ho Kwahck,Joo Young Park,Se Jong Kim,Jung Bock Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4
N/A Circulating immune Complex in Syphilis Min Geol Lee, M.D., Ho Kwahck, M.D., Joo Young Park, M.D.*, Se Jong Kim, M.D.*, Jung Bock Lee, M.D. Departments of Dermatology, Microbiology* Yonsei University College of Medicine, Seoul, Korea In this study, the author tried to clarify the relationships between the clinical stages of untreated syphilis and the positive rates of circalating immune complex(CIC). Additionally, the study looks at the duration of CIC conversion to negative in the treated previously positive patient by means of solid phase CIq enzyme assay(CIq EA), solid phase anti-CIq enzyme assay (anti-Ciq EA), and platelet aggregation test(PAT)to get the following results. The results are as follows : 1. Among the 132 untreated patients, 36 patients(27.3%) were CIC positive in at least one of the three tests performed, and in the negative groups, two out of 50(4.0%) were CIC positive. 2. The positive rates beginning with the highest were as follows : secondary syphilis, early latent syphilis, late latent syphilis, and primary syphilis. 3. Among the seven CIq EA positive patients before treatment, two had negative conversion in the first week after treatment. Among the remaining five, one remained positive after three weeks and four after three months. 4. Among the six anti-CIq EA positive patients before treatment, there were three negative conversions after two weeks, one after three months ; the remaining two stayed positive. 5. The one PAT positive patient showed negative coversion after one week of treatment.
Serum Interleukin - 8 Levels in Leprosy Patients
Lew, Wook,Kwahck, Ho,Chang, Soo Kyoung 대한피부과학회 1999 Annals of Dermatology Vol.11 No.1
Background : Interleukin(IL)-8 is a potent chemotactic factor for neutrophils which was induced by tumor necrosis factor-a and IL-1. Serum IL-8 level was known to be associated with the poor prognosis of tuberculosis and IL-8 mRNA was increased in the tissue of erythema nodosum leprosum. Objective : Our purpose was to investigate whether the serum IL-8 levels of leprosy patients are different from those of controls and whether the severity of the leprosy is associated with the serum IL-8 level. Methods : Twenty eight patients with leprosy and fourteen healthy adults were used in this study. Serum IL-8 levels were detected by enzyme immunoassay. Results : There were na statistically significant differences in the serum IL-8 levels between the twenty eight leprosy patients and the fourteen healthy control serums (29.99±53.14 vs 2.52±7.53) nor was the detection rate between the groups (9/28 vs 1/14) significant. There were also no statistically significant differences between the serum IL-8 concentrations of the patients with high bacterial indexes and the patients with low bacterial indexes (30.22±63.64 vs 29.73±41.14). Conclusion : Serum levels and the detection rate of IL-8 in the leprosy patients were not different from the control group and the severity of the disease was not associated with the IL-8 levels.
Serum Levels of Type 2 Chemokines in Lepromatous Leprosy Patients
Lew, Wook,Nakamura, Koichiro,Tada, Yayoi,Kwahck, Ho,Chang, Soo Kyoung,Tamaki, Kunihiko The Korean Association of Immunobiologists 2002 Immune Network Vol.2 No.4
Background: The type 2 deviated immunological state is predominant in lepromatous leprosy. Erythema nodosum leprosum (ENL) is an immune-complex mediated reaction that typically occurs in lepromatous leprosy. To date, the serum levels of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-2 receptor, IL-10, IL-$1{\beta}$, IL-1 receptor antagonist and monocyte chemoattractant protein-1 (MCP-1) were reported to be higher in lepromatous leprosy. TNF-${\alpha}$ is also known to be higher in ENL, which is reduced after thalidomide treatment. However the serum type 2 chemokine levels in lepromatous leprosy patients have not been reported. Methods: The serum levels of the type 2 chemokines such as thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and eotaxin together with IL-12 and IL-10 in the sera from leprosy patients were detected using an enzyme-linked solvent assay (ELISA) method. Results: The Serum TARC, MDC, eotaxin, IL-10 and IL-12 levels in lepromatous leprosy patients were not significantly different from the normal control levels. The serum levels were not significantly different between the paucibacillary group and multibacillary group. The serum TARC or MDC levels in the ENL patients were more reduced after a treatment containing thalidomide. Conclusion: The type 2 chemokines are not related to the severity of lepromatous leprosy. The larger reducing effect of the TARC or MDC levels in ENL patients by a treatment containing thalidomide suggests the potential role of these chemokines in the development of ENL and the therapeutic mechanism of thalidomide.