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PIV Measurement of Inlet and Outlet Flow of Contra-Rotating Small-Sized Cooling Fan
Shigemitsu, Toru,Fukuda, Hiroaki,Fukutomi, Junichiro Korean Society for Fluid machinery 2016 International journal of fluid machinery and syste Vol.9 No.2
Contra-rotating rotors have been adopted for some of the cooling fans to meet the demand for the high pressure and large flow rate. Therefore, it is important to clarify its inlet and outlet flows by experiments for the high performance and stable operation. PIV measurements were conducted at the design and partial flow rates. In the present paper, the inlet and outlet flow conditions of the contra-rotating small-sized cooling fan with a 40mm square casing are studied by using PIV measurement. Furthermore, improvements of the flow condition and design guideline to increase the performance were discussed based on the experimental results.
PIV Measurement of Inlet and Outlet Flow of Contra-Rotating Small-Sized Cooling Fan
Toru Shigemitsu,Hiroaki Fukuda,Junichiro Fukutomi 한국유체기계학회 2016 International journal of fluid machinery and syste Vol.9 No.2
Contra-rotating rotors have been adopted for some of the cooling fans to meet the demand for the high pressure and large flow rate. Therefore, it is important to clarify its inlet and outlet flows by experiments for the high performance and stable operation. PIV measurements were conducted at the design and partial flow rates. In the present paper, the inlet and outlet flow conditions of the contra-rotating small-sized cooling fan with a 40mm square casing are studied by using PIV measurement. Furthermore, improvements of the flow condition and design guideline to increase the performance were discussed based on the experimental results.
Shinichi Togami,Mika Fukuda,Mika Mizuno,Shintaro Yanazume,Hiroaki Kobayashi 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.6
Objective: This study aimed to validate the surgical and oncologic outcomes of robotic surgery with sentinel node navigation surgery (SNNS) in endometrial cancer. Methods: This study included 130 patients with endometrial cancer, who underwent robotic surgery, including hysterectomy, bilateral salpingo-oophorectomy, and pelvic SNNS at the Department of Obstetrics and Gynecology of Kagoshima University Hospital. Pelvic sentinel lymph nodes (SLNs) were identified using the uterine cervix 99m Technetium-labeled phytate and indocyanine green injections. Surgery-related and survival outcomes were also evaluated. Results: The median operative and console times and volume of blood loss were 204 (range: 101–555) minutes, 152 (range: 70–453) minutes, and 20 (range: 2–620) mL, respectively. The bilateral and unilateral pelvic SLN detection rates were 90.0% (117/130) and 5.4% (7/130), respectively, and the identification rate (the rate at which at least one SLN could be identified on either side) was 95% (124/130). Lower extremity lymphedema occurred in only 1 patient (0.8%), and no pelvic lymphocele occurred. Recurrence occurred in 3 patients (2.3%), and the recurrence site was the abdominal cavity, with dissemination in 2 patients and vaginal stump in one. The 3-year recurrence-free survival and 3-year overall survival rates were 97.1% and 98.9%, respectively. Conclusion: Robotic surgery with SNNS for endometrial cancer showed a high SLN identification rate, low occurrence rates of lower extremity lymphedema and pelvic lymphocele, and excellent oncologic outcomes.
Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain
Shimada, Nobuko,Handa, Setsuko,Uchida, Yoshiaki,Fukuda, Mitsugu,Maruyama, Naoki,Asaga, Hiroaki,Choi, Eun-Kyoung,Lee, Jaewon,Ishigami, Akihito Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of neuroscience research Vol.88 No.4
<P>Peptidylarginine deiminases (PADs) are a group of posttranslational modification enzymes that citrullinate (deiminate) protein arginine residues in a Ca<SUP>2+</SUP>-dependent manner. Enzymatic citrullination abolishes positive charges of native protein molecules, inevitably causing significant alterations in their structure and functions. Among the five isoforms of PADs, PAD2 and PAD4 are proved occupants of the central nervous system (CNS), and especially PAD2 is a main PAD enzyme expressed in the CNS. We previously reported that abnormal protein citrullination by PAD2 has been closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and prion disease. Protein citrullination in these patients is thought to play a role during the initiation and/or progression of disease. However, the contribution of changes in PAD2 levels, and consequent citrullination, during developmental and aging processes remained unclear. Therefore, we used quantitative real-time RT-PCR, Western blot analysis, and immunohistochemical methods to measure PAD2 expression and localization in the brain during those processes. PAD2 mRNA expression was detected in the brains of mice as early as embryonic day 15, and its expression in cerebral cortex, hippocampus, and cerebellum increased significantly as the animals aged from 3 to 30 months old. No citrullinated proteins were detected during that period. Moreover, we found here, for the first time, that PAD2 localized specifically in the neuronal cells of the cerebral cortex and Purkinje cells of the cerebellum. These findings indicate that, despite PAD2's normally inactive status, it becomes active and citrullinates cellular proteins, but only when the intracellular Ca<SUP>2+</SUP> balance is upset during neurodegenerative changes. © 2009 Wiley-Liss, Inc.</P>