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Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
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학교 신축 공사장 화재원인과 대책
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대규모 건물군의 사설지역방재센터
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Acceleration of microalgal biofilm formation on PET by surface engineering
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지방자치단체의 청년 정책개발 사례연구: 광주광역시 동구를 중심으로
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낙동강(洛東江) 중류수계(中流水系)의 수질조사(水質調査) 연구(硏究)$(1978{\sim}80$년(年))
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- 저자 : Hetrick, William P. (검색결과 4 건)
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Rynarzewska Ania Izabela,LeMay Stephen A.,Helms Marilyn M.,Hetrick Eliza 한국마케팅과학회 2024 마케팅과학연구 Vol.34 No.1
Consumer polarization leading to buycotts and boycotts was magnified by the global crisis of 2020–2021 which changed consumer priorities and business practices: in-person shopping decreased, while social distancing, remote work, and media consumption increased. In this context, we examined the relationships among egoism, empathy, and consumer interest in social topics. These topics included employee treatment, social justice, and the environment. We highlighted aligning Corporate Social Responsibility (CSR) efforts with consumer values. Using a survey method and structural equation modeling, we found such efforts increased consumer buycott. In this research we addressed whether consumers were motivated by empathy or egoism to engage in buycotting during global crisis. Consumers reacted to a firm’s adherence to health and safety guidelines, respect for human rights, and engaged in environmental protection. This study contributes to the literature on CSR and prosocial behavior. It examined the relationships among key consumer characteristics and corporate behavior in times of crisis and expands the existing literature on psychological factors that play a role in buycotting. The findings are applicable to policy makers, academic literature, and practice as it offers practical recommendations on how companies might consider realignment of CSR activities during crisis. It also suggests directions for future research.
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Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis
Kim, Dae-Jin,Kent, Jerillyn S.,Bolbecker, Amanda R.,Sporns, Olaf,Cheng, Hu,Newman, Sharlene D.,Puce, Aina,O’Donnell, Brian F.,Hetrick, William P. Oxford University Press 2014 Schizophrenia bulletin Vol.40 No.6
<P>Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I–IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.</P>
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Hoover-Fong, J.,Sobreira, N.,Jurgens, J.,Modaff, P.,Blout, C.,Moser, A.,Kim, O.H.,Cho, T.J.,Cho, S.,Kim, S.,Jin, D.K.,Kitoh, H.,Park, W.Y.,Ling, H.,Hetrick, Kurt N.,Doheny, Kimberly F.,Valle, D.,Pauli University of Chicago Press [etc.] 2014 American journal of human genetics Vol.94 No.1
Spondylometaphyseal dysplasias (SMD) constitute a rare group of bone disorders. Two members of the SMD group have distinctive ophthalmologic manifestations: SMD with cone-rod dystrophy (SMD-CRD; MIM 608940) and axial SMD with retinal degeneration (MIM 602271). Additional features of SMD-CRD include rhizomelia, lower extremity bowing, evolving anterior vertebral protrusions, metaphyseal cupping, and progressive visual impairment with pigmentary maculopathy and electroretinographic evidence of cone-rod dysfunction. Affected siblings have been described, thus suggesting autosomal recessive inheritance. Here eight individuals from 6 unrelated families with SMD-CRD were submitted to the Baylor-Hopkins Center for Mendelian Genomics (BHCMG). Patients 1, 2, 4-6 (Walters et al, 2004) and 7 (Kitoh et al, 2011) were described previously. Patient 8 has not reached final adult height, but is short for his age (Z=-7.6) with lower extremity bowing and diagnosis of retinal dystrophy affecting both cones and rods made at age 45 months. Using WES and targeted Sanger sequencing, we found 8 rare PCYT1A variants (1 nonsense, 1 frame shifting indel, and 6 missense variants) present either in the homozygous or compound heterozygous state in all 8 individuals. PCYT1A encodes the alpha isoform of an enzyme known as CTP (phosphocholine cytidylytransferase), essential for phosphotidylcholine synthesis. Mutations in genes involved in fatty acid metabolism have been implicated in other dysplasias (e.g. RCDP and Conradi-Hunermann), as well as retinal disease where there are deficient or abnormal fatty acids (e.g. eicosapentanoic and docosahexanoic acid). Further examination of phospholipid metabolism may lead to the genetic etiology of other SMDs, particularly those with ocular manifestations.
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